Article(id=1304438801967902823, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260019, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728662400000, receivedDateStr=2024-10-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788932045689, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788932045689, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788932045689, creator=13701087609, updateTime=1788932045689, updator=13701087609, issue=Issue{id=1304438786377674789, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='1', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1768838400000', pubDateStr='2026-01-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788932041973, creator='13701087609', updateTime=1788934739716, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304450101590651052, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304450101590651053, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=101, endPage=105, ext={EN=ArticleExt(id=1304438802290864233, articleId=1304438801967902823, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Therapeutic Effect of Wang's Sanhe Formula on Patients with Prostatic Hyperplasia of Kidney Deficiency and Blood Stasis Syndrome and Its Impact on Bladder Function, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To observe the therapeutic effect of of Wang's Sanhe (lychee, hawthorn and mandarin orange seed) Formula in the treatment of kidney deficiency and stasis type prostatic hyperplasia and its effect on patients' bladder function.Methods: 120 patients with kidney deficiency and stasis type prostatic hyperplasia admitted to the Affiliated Hospital of Shanxi University of Traditional Chinese Medicine from January 2022 to June 2024 were selected and divided into two groups by lottery method. The conventional group was treated with tamsulosin hydrochloride capsule, and the Wang's Sanhe Formula group was combined with Wang's Sanhe Formula on the basis of the conventional group. Bladder function, prostate volume, 24h urination frequency, Chinese medicine symptom scores and changes in the levels of prostate - specific antigen (PSA), monocyte chemokine 1 (MCP - 1) and interleukin-8 (IL- 8) were compared before and after the treatment in the two groups, and adverse reactions were counted in the two groups.Results: Comparison of bladder function before treatment between the conventional group and Wang's Sanhe Formula group showed no statistically significant difference (P > 0.05). Maximum urinary flow rate (Qmax), average urinary flow rate (Qave) and effective bladder capacity were all higher after treatment in the conventional group and Wang's Sanhe Formula group than before treatment, and the differences in voiding time, urinary flow time and time to peak were not statistically significant when compared with those before treatment (P > 0.05). Qmax, Qave, and effective bladder capacity were higher in Wang's Sanhe Formula group after treatment than in the conventional group, and there was no statistically significant difference in voiding time, urine flow time, and time to peak compared with the conventional group (P > 0.05). Comparison of prostate volume, 24h urination frequency and TCM symptom scores before treatment between the conventional group and Wang's Sanhe Formula group, the difference was not statistically significant (P > 0.05). The prostate volume, 24 h urination frequency, and TCM symptom scores decreased after treatment in the conventional group and Wang's Sanhe Formula group compared with those before treatment, and the Wang's Sanhe Formula group was lower than the conventional group after treatment (P < 0.05). Comparison of serum PSA, MCP - 1 and IL - 8 before treatment between the conventional group and Wang's Sanhe Formula group showed no statistically significant difference (P >0.05). Serum PSA, MCP - 1, and IL - 8 decreased after treatment in both the conventional group and Wang's Sanhe Formula group compared with the pre - treatment period, and were lower in the Wang's Sanhe Formula group than in the conventional group after treatment (P < 0.05). Comparing the incidence of adverse reactions between the two groups (11.67% in the conventional group and 8.33% in the Wang's Sanhe Formula group), the difference was not statistically significant (P > 0.05).Conclusion: Wang's Sanhe Formula applied to kidney deficiency and stasis type prostatic hyperplasia can reduce the size of prostate, improve bladder function, reduce serum PSA, MCP - 1, IL - 8 levels and alleviate symptoms., authors=XUE Yunfeng¹, PEI Miaorong², authorsList=XUE Yunfeng, PEI Miaorong, authorCompany=1 The Affiliated Hospital of Shanxi University of Chinese Medicine, Taiyuan 030024, China;
2 Shanxi University of Chinese Medicine, Taiyuan 030619, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=山西省重点研发计划（大健康与生物医药及有关社会发展领域）项目 (202102130501006)), CN=ArticleExt(id=1304438802194395240, articleId=1304438801967902823, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=王氏三核方治疗肾虚瘀阻型前列腺增生症的效果及对患者膀胱功能的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=目的： 观察王氏三核方治疗肾虚瘀阻型前列腺增生症的效果及对患者膀胱功能的影响。 方法： 选取2022年1月—2024年6月山西中医药大学附属医院收治的肾虚瘀阻型前列腺增生症患者120例，采用抽签法分为常规组和王氏三核方组，每组60例。常规组采用盐酸坦索罗辛胶囊治疗，王氏三核方组在常规组基础上联合王氏三核方治疗。比较两组治疗前后膀胱功能、前列腺体积、24 h排尿次数、中医症状评分及前列腺特异抗原（PSA）、单核细胞趋化因子1（MCP - 1）、白细胞介素- 8（IL - 8）水平变化，统计两组不良反应。 结果： 治疗前，常规组与王氏三核方组膀胱功能比较，差异无统计学意义（P >0.05）。治疗后，两组最大尿流率（Qmax）、平均尿流率（Qave）、有效膀胱容量均较治疗前升高（P <0.05），排尿时间、尿流时间、达峰时间与治疗前比较，差异无统计学意义（P > 0.05）。治疗后，王氏三核方组Qmax、Qave、有效膀胱容量均高于常规组（P < 0.05），排尿时间、尿流时间、达峰时间与常规组比较，差异无统计学意义（P > 0.05）。治疗前，两组前列腺体积、24 h排尿次数、中医症状评分比较，差异无统计学意义（P > 0.05）。治疗后，两组前列腺体积、24 h排尿次数、中医症状评分均较治疗前下降（P < 0.05），且王氏三核方组低于常规组（P < 0.05）。治疗前，两组PSA、MCP - 1、IL - 8比较，差异无统计学意义（P > 0.05）。治疗后，两组PSA、MCP - 1、IL - 8均较治疗前下降（P < 0.05），且王氏三核方组低于常规组（P < 0.05）。两组不良反应发生率比较，差异无统计学意义（P > 0.05）。 结论： 王氏三核方应用于肾虚瘀阻型前列腺增生症可缩小前列腺体积，改善膀胱功能，降低PSA、MCP - 1、IL - 8水平，减轻相关症状。, authors=薛云峰¹, 裴妙荣², authorsList=薛云峰, 裴妙荣, authorCompany=1 山西中医药大学附属医院，山西 太原 030024;
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