Article(id=1304438792442631127, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260006, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1725638400000, receivedDateStr=2024-09-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788932043419, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788932043419, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788932043419, creator=13701087609, updateTime=1788932043419, updator=13701087609, issue=Issue{id=1304438786377674789, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='1', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1768838400000', pubDateStr='2026-01-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788932041973, creator='13701087609', updateTime=1788934739716, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304450101590651052, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304450101590651053, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=33, endPage=39, ext={EN=ArticleExt(id=1304438792706872281, articleId=1304438792442631127, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Pharmacokinetics of Paeoniflorin Influenced by Aurantii Fructus Carbon Quantum Dots Based on Indirect Competitive Enzyme - Linked Immunosorbent Assay, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To investigate the pharmacokinetic effects of Aurantii Fructus Carbon Quantum Dots (AFIC-CDs) on paeoniflorin (PF), the main active component of Paeonia.Methods: Male Kunming mice were randomly divided into three groups: high - dose AFIC - CDs (120 mg·mL^-1) and PF co - administration group (H), low - dose AFIC - CDs (60 mg·mL^-1) and PF co - administration group (L), and PF alone (2.0 mg·mL^-1) group (S). Mice were orally administered mixed solutions of high or low - dose AFIC - CDs with the same dose of PF, or PF alone. Paeoniflorin levels in the mouse blood were determined by indirect competitive enzyme - linked immunosorbent assay(icELISA) using anti - PF monoclonal antibodies, and pharmacokinetic parameters of PF were compared among the groups.Results: Co - administration of AFIC - CDs with PF significantly increased PF blood concentration and the area under the blood concentration - time curve (AUC - t) (P < 0.05, P < 0.01), with increases observed as the AFIC-CDs concentration increased. Compared to PF administration alone, the Cmax of PF in the high - dose and low - dose AFIC - CDs + PF groups increased from (695.43 ± 229.73) ng·mL^-1 to (1 615.31 ± 245.16) ng·mL^-1 and(973.11 ± 155.90) ng·mL^-1, respectively. The AUC - t increased from (90 181.22 ± 20 926.42) ng·min·mL^-1 to(257 510.74 ± 26 729.64) ng·min·mL^-1 and (116 654.67 ± 11 770.02) ng·min·mL^-1, respectively.Conclusion: AFIC - CDs can enhance the bioavailability of PF, providing scientific evidence for clinical co - medication to improve therapeutic efficacy., authors=LI Menghan¹, WANG Suna¹, ZOU Peng¹, HUANG Yan¹, HE Chenxin¹, MA Huagen¹, ZHAO Yan¹, KONG Hui¹, authorsList=LI Menghan, WANG Suna, ZOU Peng, HUANG Yan, HE Chenxin, MA Huagen, ZHAO Yan, KONG Hui, authorCompany=1 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=北京市自然科学基金-海淀原始创新联合基金资助项目 (L222132); 中央高校基本科研业务费专项资金项目 (2024-JYB-JBZD-040)), CN=ArticleExt(id=1304438792622986200, articleId=1304438792442631127, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于间接竞争性酶联免疫吸附法研究枳实炭碳点对芍药苷的药代动力学影响, columnId=1303760928135213534, journalTitle=中医药学报, columnName=中药研究, runingTitle=null, highlight=null, articleAbstract=目的： 研究枳实炭碳点（AFIC - CDs）对芍药主要活性成分芍药苷（PF）的药代动力学影响。 方法： 将雄性昆明小鼠随机分为3组，高剂量AFIC - CDs（120 mg·mL⁻¹）与PF联用组（H组）、低剂量AFIC - CDs（60 mg·mL⁻¹）与PF联用组（L组）、单独PF（2.0 mg·mL⁻¹）组（S组），分别用高、低剂量AFIC - CDs与同一剂量PF制备的混合溶液及单独PF溶液灌胃，采用抗PF -单克隆抗体间接竞争性酶联免疫吸附法（icELISA）测定小鼠血液中的PF含量，比较各组小鼠的PF药代动力学参数。 结果： AFIC-CDs与PF联合应用能增加PF的血药浓度和血药浓度时间曲线下面积（P < 0.05，P < 0.01），并且随AFIC - CDs的浓度增加而增加。相较于PF单独给药，高、低剂量AFIC - CDs与PF联用组小鼠体内PF的C_max分别从（695.43 ± 229.73）ng·mL⁻¹增加至（1 615.31 ± 245.16）ng·mL⁻¹、（973.11 ± 155.90）ng·mL⁻¹；AUC_0-t分别从（90 181.22 ± 20 926.42） ng·min·mL⁻¹增加至（257 510.74 ± 26 729.64） ng·min·mL⁻¹、（116 654.67 ± 11 770.02） ng·min·mL⁻¹。 结论： AFIC - CDs可提高PF的生物利用度，为临床联合用药从而提高疗效提供了科学依据。, authors=李梦含¹, 王苏娜¹, 邹鹏¹, 黄燕¹, 何晨昕¹, 马华根¹, 赵琰¹, 孔慧¹, authorsList=李梦含, 王苏娜, 邹鹏, 黄燕, 何晨昕, 马华根, 赵琰, 孔慧, authorCompany=1 北京中医药大学中医学院，北京 100029, correspAuthors=* 孔慧（1976-），女，博士，副教授，硕士生导师，主要从事经典方药现代应用的基础研究。, authorNote=李梦含（1998-），女，硕士研究生，主要从事经典方药现代应用的基础研究。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=ymG9C9UpYBQgL8ber+68vg==, pdfFileSize=5773788, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1304438792857867226, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1304438792442631127, language=CN, orderNo=1, keyword=枳实炭碳点), 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