Article(id=1304438792576852389, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260005, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1726243200000, receivedDateStr=2024-09-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788932043451, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788932043451, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788932043451, creator=13701087609, updateTime=1788932043451, updator=13701087609, issue=Issue{id=1304438786377674789, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='1', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1768838400000', pubDateStr='2026-01-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788932041973, creator='13701087609', updateTime=1788934739716, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304450101590651052, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304450101590651053, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438786377674789, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=26, endPage=32, ext={EN=ArticleExt(id=1304438792874647975, articleId=1304438792576852389, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on Hepatotoxicity of Dictamni Cortex Water Extract in Rats Based on Liver Lipid Metabolism Disorder, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To explore the mechanism of liver injury induced by Dictamni Cortex water extract through interference with lipid metabolism in the liver.Methods: Thirty - two SPF - grade male SD rats were randomly divided into four groups: control group, high - dose Dictamni Cortex group (8.1 g/kg), medium - dose group (2.7 g/kg), and low - dose group (0.9 g/kg), with 8 rats in each group. The rats were administered by gavage for 8 weeks. Liver weight, liver - to - body weight ratio, and liver toxicity - related indicators were measured to observe changes in the rats' liver. Hematoxylin - eosin (HE) staining and Oil Red O staining were used to assess the pathological changes and lipid droplet accumulation in liver tissues. The mRNA levels of AMPK, PPAR - α, IL - 1β, and TNF - α were detected in liver tissues. Lipid levels in the liver were analyzed by LC - MS/MS, and multivariate statistical analysis was used to identify differentially expressed lipid metabolites.Results: Compared with the control group, the liver - to - body weight ratio was increased in all Dictamni Cortex dose groups(P < 0.01, P < 0.001). In the high - dose group, AST、ALT、ALB levels were significantly increased (P < 0.05, P < 0.001). HE and Oil Red O staining showed that the high - dose group significantly induced fatty liver lesions in rats. The mRNA levels of inflammatory factors IL - 1β and TNF- α were significantly increased (P < 0.01), while the mRNA levels of PPAR - α, were significantly reduced (P <0.01). Lipidomics analysis showed that, compared to the control group, 156 lipid species were significantly altered in the high - dose group, including glycerolipids, phosphatidylcholine, sphingolipids, etc. Specific lipids such as PC(16∶0/18∶2), PC(16∶0/18∶1)、PC(14∶0/18∶2)、PC(15∶0/18∶2)、TG(16∶0/16∶0/16∶0), TG(18∶0/16∶0/16∶0)、SM(d42∶1), SM (d42∶2), SM (d42∶3) showed significantly variation levels after treatment. These results suggest that the high - dose Dictamni Cortex water extract disturbed lipid metabolism in the liver of rats.Conclusion: The water extract of Dictamni Cortex induces liver injury in rats by interfering with lipid metabolism, particularly sphingolipids (SM), ceramides (Cer), triglycerides (TG), and phosphatidylcholine (PC)., authors=GAO Rui¹, LU Fang¹, SUN Huijuan¹, ZHANG Mengmeng¹, DENG Geyu¹, HUANG Lin¹, LIU Shumin¹, authorsList=GAO Rui, LU Fang, SUN Huijuan, ZHANG Mengmeng, DENG Geyu, HUANG Lin, LIU Shumin, authorCompany=1 Heilongjiang University of Chinese Medicine, Harbin 150040, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家重点研发计划-中医药现代化 (2022YFC3502100,2022YFC3502102,2022YFC3502102-04)), CN=ArticleExt(id=1304438792807539110, articleId=1304438792576852389, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于肝脏脂质代谢紊乱的白鲜皮水提液致大鼠肝毒性研究, columnId=1303760926633652690, journalTitle=中医药学报, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=目的： 揭示白鲜皮干扰脂质代谢紊乱导致大鼠肝损伤的机制。 方法： 32只SPF级SD雄性大鼠随机分成空白组、白鲜皮高剂量组（8.1 g/kg）、白鲜皮中剂量组（2.7 g/kg）、白鲜皮低剂量组（0.9 g/kg），每组8只，灌胃给药8周，检测大鼠体质量及肝脏体质量比、肝毒性相关指标观察大鼠肝脏的变化；HE染色与油红O染色法评价肝组织的病理变化及脂滴聚集情况；检测肝组织中AMPK、PPAR - α、IL - 1β、TNF - α的mRNA含量；使用高效液相色谱-质谱联用（LC - MS/MS）技术检测大鼠肝脏脂质水平变化，采用多元统计分析筛选其中的差异脂质代谢物。 结果： 与空白组比较，白鲜皮各剂量组的肝脏体质量比增加（P < 0.01，P < 0.001），大鼠血清中谷草转氨酶（AST）、谷丙转氨酶（ALT）、白蛋白（ALB）水平显著升高（P < 0.05，P < 0.001），HE染色与油红O染色表明白鲜皮高剂量组可明显引起大鼠肝脏的脂肪性病变，肝组织中炎症因子IL - 1β、TNF - α的mRNA水平显著升高（P < 0.01），PPAR - α的mRNA水平显著降低（P < 0.01），脂质组学分析发现，与空白组比较，白鲜皮高剂量组有156个脂质发生了显著改变，主要有甘油脂类、磷脂酰胆碱类、鞘脂类等，具体表现为PC （16∶0/18∶2）、PC （16∶0/18∶1）、PC（14∶0/18∶2）、PC（15∶0/18∶2）、TG（16∶0/16∶0/16∶0）、TG（18∶0/16∶0/16∶0）、SM（d42∶1）、SM（d42∶2）、SM（d42∶3）等在给药后含量明显变化，表明白鲜皮高剂量组给药后引起了大鼠的肝脏脂质代谢水平紊乱。 结论： 白鲜皮水提液通过干扰鞘磷脂（SM）、神经酰胺（Cer）、甘油三酯（TG）、磷脂酰胆碱（PC）等脂质代谢引起大鼠肝损伤。, authors=高蕊¹, 卢芳¹, 孙慧娟¹, 张萌萌¹, 邓戈宇¹, 黄琳¹, 刘树民¹, authorsList=高蕊, 卢芳, 孙慧娟, 张萌萌, 邓戈宇, 黄琳, 刘树民, authorCompany=1 黑龙江中医药大学，黑龙江 哈尔滨 150040, correspAuthors=* 刘树民（1963-），男，博士，教授，博士生导师，研究方向：中药药性理论及药物功效研究。, authorNote=高蕊（1996-），女，硕士研究生，专业：临床中药学。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=Kjg15e0qy5MAhccF7jQMsQ==, pdfFileSize=7686884, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=[Author(id=1307454321889665143, tenantId=1146029695717560320, journalId=null, 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