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tenantId=1146029695717560320, journalId=1315121837170065538, language=CN, title=复方余甘子-三白纳米乳的制备工艺优化及抗氧化活性评价, columnId=null, journalTitle=中医学报, columnName=中药研究, runingTitle=null, highlight=null, articleAbstract=目的:筛选优化复方余甘子-三白纳米乳（CPA-NE）的制备工艺，并对其抗氧化活性进行评价。方法:应用伪三元相图法结合单因素试验，以平均粒径为指标通过Box-Behnken响应面设计优化CPA-NE的制备工艺，并对其外观形貌、粒径分布、包封率、稳定性和抗氧化活性等进行评价。结果:优化的处方条件为油相4%，吐温80 18%，无水乙醇6%，水相72%;CPA-NE包封率为（90.16±2.6）%，粒径为（14.33±0.53） nm,PDI为（0.06±0.01）,Zeta电位为（-10.29±1.10） m V,p H值为（6.53±0.01），黏度为（41.51±0.30） m Pa·s⁻¹，浊度为（5.17±0.19） cm⁻¹。CPA-NE外观澄清透明，为O/W型纳米乳，形态呈规整的类球形，稳定性好。体外经皮释放研究结果:CPA-NE累计释放量高达843.37μg·cm⁻²，具有良好的药物经皮促渗作用。抗氧化实验中CPA-NE清除DPPH与ABTS自由基性能显著。结论:经伪三元相图法结合响应面法优化得到的CPA-NE稳定性好，具有良好的经皮促透作用和抗氧化活性，可为复方中药纳米乳液护肤品的研制及应用提供参考。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, 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