中医学报

中医药调控转录因子EB干预阿尔茨海默病研究进展

崔正浩 ¹,² , 谢治深 ¹,² , 黄艳丽 ¹,² , 初双 ¹,² , 吴丽敏 ¹,² , 张振强 ¹,²

中医学报 | 述评 2026,41(1): 124-131

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中医学报 |述评 2026 , 41 (1) : 124 -131

中医药调控转录因子EB干预阿尔茨海默病研究进展

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崔正浩¹,², 谢治深¹,², 黄艳丽¹,², 初双¹,², 吴丽敏¹,², 张振强¹,²

作者信息

^1.河南中医药大学第一附属医院

^2.河南中医药大学中医药科学院

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doi: 10.16368/j.issn.1674-8999.2026.01.020

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转录因子EB(transcription factor EB,TFEB)是自噬小体、溶酶体形成的关键调控因子，其功能障碍在阿尔茨海默病(Alzheimer's disease,AD)发病机制中具有关键作用，因此基于TFEB改善自噬流被视为治疗AD的潜在靶点。研究表明，中医药可多靶点、多环节调控TFEB干预AD，如白术、青羊参等单味药，加减薯蓣丸等中药复方，以及雷公藤红素、常春藤皂苷元、绿原酸等中药活性成分，均可通过m TOR、PPARα、GSK3β、SIRT1等信号通路促进TFEB核转位，改善自噬流，加速Aβ与p-Tau蛋白清除，改善模型动物认知功能。针刺、艾灸、运动等非药物疗法亦被证实具有激活TFEB通路、改善AD自噬功能的作用。但现有研究主要集中于m TORC1、PPARα等少数通路;多数活性成分生物利用度与血脑屏障透过率尚不明确，且实验研究多停留在细胞与小鼠痴呆模型中，缺乏临床对照试验验证，未来需深化多靶点机制研究，以期为AD的临床防治及药物开发提供理论参考。

关键词

阿尔茨海默病 / 中医药 / TFEB / 自噬 / 多靶点治疗 / 信号通路

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崔正浩, 谢治深, 黄艳丽, 初双, 吴丽敏, 张振强. 中医药调控转录因子EB干预阿尔茨海默病研究进展. 中医学报, 2026 , 41 (1) : 124 -131 . DOI: 10.16368/j.issn.1674-8999.2026.01.020

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国家自然科学基金项目

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2026年第41卷第1期

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首发时间：2026-10-22

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国家自然科学基金项目

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^1.河南中医药大学第一附属医院

^2.河南中医药大学中医药科学院

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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