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tenantId=1146029695717560320, journalId=1315121837170065538, language=CN, title=中医药修复DNA损伤治疗慢性阻塞性肺疾病的作用机制研究进展, columnId=null, journalTitle=中医学报, columnName=述评, runingTitle=null, highlight=null, articleAbstract=DNA损伤及修复功能障碍在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的病理过程中发挥重要作用，调控DNA损伤修复通路已成为COPD潜在的治疗策略之一。中医药在COPD防治中独具优势，日本银杏提取物FA-1、黄芪提取物HDTIC-1/HDTIC-2、黄酮类化合物等中药单体及提取物，可通过减轻氧化应激、增强DNA修复能力、抑制炎症反应等多途径保护肺组织，减缓COPD进程。但现有研究仍存在一些局限，如其他修复途径的作用尚未明确、中药复方研究较少、作用靶点及机制阐述不够深入，且实验多局限于细胞与动物层面。未来需进一步从多环节、多角度系统开展中医药修复DNA损伤的作用机制研究，尤其加强中药复方的体内外实验，以明确其关键靶点与通路，为COPD的中医药防治提供更充分的理论依据。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, 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