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tenantId=1146029695717560320, journalId=1315121837170065538, language=CN, title=中医药治疗颈动脉粥样硬化斑块的临床研究证据图分析, columnId=null, journalTitle=中医学报, columnName=专题研究:动脉粥样硬化的中医药防治策略, runingTitle=null, highlight=null, articleAbstract=目的:本研究旨在采用证据图对中医药治疗颈动脉粥样硬化斑块的临床研究进行系统梳理及质量评价。方法:计算机检索8个中英文数据库、常用指南库及指南相关网站。检索时限为建库至2025年2月20日。由2位研究人员进行独立筛选、信息提取及质量评价，利用文字结合图表的形式展示临床研究证据分布及证据质量。结果:最终纳入文献1 019篇，其中临床研究997篇、系统综述/Meta分析20篇、指南/共识2篇。近两年该病总体发文量呈下降趋势。临床研究中有43.03%的研究聚焦颈动脉粥样硬化合并病研究，有324篇(32.49%)提到纳入患者的中医证型，痰瘀互结证为出现频次最高的证型。临床研究样本量多为60～300例，干预时长多为8～32周。中医药干预措施中，通心络胶囊、半夏白术天麻汤和参芪柔脉合剂是使用最多的中成药、中药经方和自拟方。对照措施以他汀类药物为主。结局指标以临床有效率、Crouse积分、颈动脉斑块内-中膜厚度(carotid intima-media thickness,c IMT)、斑块面积为主。在随机对照试验的方法学设计方面，明确提及随机序列产生方法的有379篇(40.53%)，提及分配隐藏的有12篇(1.28%);提及盲法的有28篇(2.99%)。在系统评价/Meta分析的方法学评价方面，AMSTAR 2量表评分普遍不高。结论:中医药治疗颈动脉粥样硬化斑块具有一定优势，研究数量可观。但研究质量较低，中医辨证论治方案及疗效指标明显不足，方法学设计存在缺陷。未来需要更多高质量且在中医理论指导下完成的RCT以提高循证证据级别。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, 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