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tenantId=1146029695717560320, journalId=1315121837170065538, language=CN, title=桑杏止咳方调节细胞焦亡治疗咳嗽变异性哮喘的作用机制, columnId=null, journalTitle=中医学报, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=目的:探讨桑杏止咳方对咳嗽变异性哮喘(cough variant asthma,CVA)细胞焦亡的影响。方法:将36只SD雄性大鼠随机分为6组:空白对照组、模型组、地塞米松组及桑杏止咳方低、中、高剂量组，每组6只。采用卵蛋白(ovalbumin,OVA)致敏与雾化激发法制备CVA模型。各给药组于造模第18天开始灌胃相应药物，连续14 d。检测各组大鼠气道阻力;采用苏木素-伊红(hematoxylin-eosin,HE)染色观察肺组织病理变化;通过酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)法检测血清核苷酸结合寡聚化结构域样受体蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)、胱天蛋白酶-1(cysteinyl aspartate specific proteinase-1,Caspase-1)、白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-18(interleukin-18,IL-18)等因子水平;采用蛋白免疫印迹(Western blot)法检测肺组织NLRP3、Caspase-1、消皮素D(gasdermin D,GSDMD-N)蛋白表达;通过实时荧光定量PCR(quantitative real-time PCR,qRT-PCR)法检测肺组织NLRP3、Caspase-1、GSDMD-N、IL-1β、IL-18的mRNA表达水平。结果:与空白对照组对比，模型组大鼠气道阻力显著升高(P<0.05)，肺组织炎症细胞浸润加重，血清NLRP3、Caspase-1、IL-1β、IL-18水平及肺组织Cleaved Caspase-1、NLRP3、GSDMD-N蛋白表达均显著上调(均P<0.05)，肺组织NLRP3、Caspase-1、GSDMD-N、IL-1β、IL-18的mRNA表达水平均显著升高(均P<0.05)。与模型组对比，桑杏止咳方各剂量组气道阻力显著降低(P<0.05)，肺组织病理损伤减轻，血清焦亡相关因子水平及肺组织焦亡关键蛋白与mRNA表达水平均显著下调(均P<0.05)，且高剂量组效果最为显著。结论:桑杏止咳方可有效改善CVA模型大鼠的气道高反应性及肺组织炎症损伤，其作用机制可能与抑制NLRP3/Caspase-1信号通路，进而减轻细胞焦亡有关。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=[Author(id=1319955817298768694, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1319955812798280496, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=赵永伟, orcid=null, 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中医学报
|实验研究
2026
, 41
(1) :
176
-182
桑杏止咳方调节细胞焦亡治疗咳嗽变异性哮喘的作用机制
全屏
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作者信息
- 1.乌鲁木齐市中医医院
- 2.新疆医科大学附属中医医院
Affiliations
doi: 10.16368/j.issn.1674-8999.2026.01.026
文章导航
目的:探讨桑杏止咳方对咳嗽变异性哮喘(cough variant asthma,CVA)细胞焦亡的影响。方法:将36只SD雄性大鼠随机分为6组:空白对照组、模型组、地塞米松组及桑杏止咳方低、中、高剂量组，每组6只。采用卵蛋白(ovalbumin,OVA)致敏与雾化激发法制备CVA模型。各给药组于造模第18天开始灌胃相应药物，连续14 d。检测各组大鼠气道阻力;采用苏木素-伊红(hematoxylin-eosin,HE)染色观察肺组织病理变化;通过酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)法检测血清核苷酸结合寡聚化结构域样受体蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)、胱天蛋白酶-1(cysteinyl aspartate specific proteinase-1,Caspase-1)、白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-18(interleukin-18,IL-18)等因子水平;采用蛋白免疫印迹(Western blot)法检测肺组织NLRP3、Caspase-1、消皮素D(gasdermin D,GSDMD-N)蛋白表达;通过实时荧光定量PCR(quantitative real-time PCR,qRT-PCR)法检测肺组织NLRP3、Caspase-1、GSDMD-N、IL-1β、IL-18的mRNA表达水平。结果:与空白对照组对比，模型组大鼠气道阻力显著升高(P<0.05)，肺组织炎症细胞浸润加重，血清NLRP3、Caspase-1、IL-1β、IL-18水平及肺组织Cleaved Caspase-1、NLRP3、GSDMD-N蛋白表达均显著上调(均P<0.05)，肺组织NLRP3、Caspase-1、GSDMD-N、IL-1β、IL-18的mRNA表达水平均显著升高(均P<0.05)。与模型组对比，桑杏止咳方各剂量组气道阻力显著降低(P<0.05)，肺组织病理损伤减轻，血清焦亡相关因子水平及肺组织焦亡关键蛋白与mRNA表达水平均显著下调(均P<0.05)，且高剂量组效果最为显著。结论:桑杏止咳方可有效改善CVA模型大鼠的气道高反应性及肺组织炎症损伤，其作用机制可能与抑制NLRP3/Caspase-1信号通路，进而减轻细胞焦亡有关。
咳嗽变异性哮喘
/
桑杏止咳方
/
细胞焦亡
/
NLRP3
/
Caspase-1
赵永伟, 张晓谊, 罗建江.
桑杏止咳方调节细胞焦亡治疗咳嗽变异性哮喘的作用机制.
中医学报,
2026
, 41
(1)
: 176
-182
.
DOI: 10.16368/j.issn.1674-8999.2026.01.026
- 国家自然科学基金项目
- 杰出青年科学基金项目
- 新疆维吾尔自治区自然科学基金面上项目
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2026年第41卷第1期
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doi: 10.16368/j.issn.1674-8999.2026.01.026
国家自然科学基金项目
杰出青年科学基金项目
新疆维吾尔自治区自然科学基金面上项目
1.乌鲁木齐市中医医院
2.新疆医科大学附属中医医院
https://castjournals.cast.org.cn/joweb/zyxb/CN/10.16368/j.issn.1674-8999.2026.01.026
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2种不同金属材料的力学参数
科
Family | 属数
Number of
genus | 种数
Number of
species | 占总种数比例
Percentage of
total species (%) | 属
Genus | 种数
Number of
species | 占总种数比例
Percentage of total
species (%) |
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| | | | | 小菇属 Mycena | 11 | 5.26 |
| | | | | 光柄菇属 Pluteus | 5 | 2.39 |
| | | | | 红菇属 Russula | 17 | 8.13 |
| | | | | 栓菌属 Trametes | 5 | 2.39 |
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