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tenantId=1146029695717560320, journalId=1315121837170065538, language=CN, title=中药单体调节PI3K/AKT信号通路治疗阿尔茨海默病研究进展, columnId=null, journalTitle=中医学报, columnName=述评, runingTitle=null, highlight=null, articleAbstract=中药单体通过靶向调节PI3K/AKT信号通路，在阿尔茨海默病的治疗中发挥着多靶点干预作用，其机制主要为抑制神经元凋亡、调控胰岛素信号、增强自噬清除能力及减轻氧化应激，从而降低tau蛋白过度磷酸化与Aβ沉积，最终改善认知功能。值得注意的是，不同单体对该通路表现出上调或抑制的双向调节效应，体现了中药多通路交叉影响的作用特点。当前研究存在以下不足:研究多局限于细胞与动物实验，临床研究匮乏;中药单体多靶点协同的网络调控机制尚未阐明;且现有研究多侧重单体成分，与中医整体观及复方理论的结合尚显不足。未来亟须推进临床研究，并运用系统生物学方法挖掘其多靶点协同机制，以期为深入研究中药单体治疗阿尔茨海默病及新药研发提供理论支撑及研究思路。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, 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