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tenantId=1146029695717560320, journalId=1315121837170065538, language=CN, title=基于氧化应激机制探讨中医药干预糖尿病周围神经病变的研究进展, columnId=null, journalTitle=中医学报, columnName=述评, runingTitle=null, highlight=null, articleAbstract=氧化应激是糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)发病的关键机制。红芪多糖、黄芪黄酮等中药单体，补阳还五汤、黄芪桂枝五物汤等中药复方，筋脉通、降糖通络片等中成药，以及温针灸、杵针等疗法，防治DPN均疗效确切，主要是通过调控核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)、糖基化终末产物/糖基化终末产物受体(advanced glycation end products/receptor for advanced glycation end products,AGEs/RAGE)、核因子-κB(nuclear factor-κB,NF-κB)等信号通路，发挥增强抗氧化酶活性、加速氧自由基清除及抑制脂质过氧化产物生成的作用，具有多途径、多靶点优势，且中西医结合或中医综合疗法常优于单一疗法。但当前研究仍存在样本量小、缺乏长期随访、机制阐释不够深入等不足。未来需开展高质量临床研究，并深入探索氧化应激标志物与中医证候的相关性及具体分子靶点。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, 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