Article(id=1315688512674968315, tenantId=1146029695717560320, journalId=1315121837170065538, issueId=1315688435411694395, articleNumber=null, orderNo=null, doi=10.16368/j.issn.1674-8999.2025.12.420, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752854400000, receivedDateStr=2025-07-19, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791614185732, onlineDateStr=2026-10-10, pubDate=1765296000000, pubDateStr=2025-12-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791614185732, onlineIssueDateStr=2026-10-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791614185732, creator=13701087609, updateTime=1791614185732, updator=13701087609, issue=Issue{id=1315688435411694395, tenantId=1146029695717560320, journalId=1315121837170065538, year='2025', volume='40', issue='12', pageStart='2487', pageEnd='2712', issueExtLink='null', onlineDate='null', pubDate='1765296000000', pubDateStr='2025-12-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791614167309, creator='13701087609', updateTime=1791616084449, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1315696476567744680, tenantId=1146029695717560320, journalId=1315121837170065538, issueId=1315688435411694395, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1315696476571938985, tenantId=1146029695717560320, journalId=1315121837170065538, issueId=1315688435411694395, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2707, endPage=2712, ext={EN=ArticleExt(id=1315688512872100604, articleId=1315688512674968315, tenantId=1146029695717560320, journalId=1315121837170065538, language=EN, title=CiteSpace Visualization Analysis of Traditional Chinese Medicine Treatment of Perimenopausal Insomnia, columnId=1315688484338254619, journalTitle=Acta Chinese Medicine, columnName=Clinical Study, runingTitle=null, highlight=null, articleAbstract=

Objective:To analyze the research trends and hotspots of traditional Chinese medicine(TCM)in the treatment of perimenopausal insomnia,providing references for clinical treatment in this field.Methods:Literature related to TCMtreatment of perimenopausal insomnia was retrieved from the China National Knowledge Infrastructure(CNKI),VIP Chinese Science and Technology Journal Database(VIP),Wanfang Database,and China Biomedical Literature Service System(SinoMed)from database inception to June 26,2024. CiteSpace 6.1R6 software was used for visual analysis of keywords,authors,and research institutions.Results:A total of 1 401 related publications were included,involving 626 authors,with core authors represented by Li Hong,Yu Xintong,and Ding Shudong.Research institutions with higher publication output include Heilongjiang University of Chinese Medicine,Chengdu University of Traditional Chinese Medicine,and Guangzhou University of Chinese Medicine.A total of 608 keywords were included,with high centrality and high-frequency keywords including insomnia,menopause,perimenopausal insomnia,and acupuncture.Eleven keyword clusters were formed,with cluster labels including perimenopausal insomnia,sleep disorders,sleep quality,and clinical research.Emerging keywords include menopausal syndrome,traditional Chinese medicine therapies,and sex hormones. Conclusion:Research on treating perimenopausal insomnia with traditional Chinese medicine in China is steadily increasing,mainly focusing on clinical studies.Research on TCMtreatments for perimenopausal insomnia is centered on the clinical efficacy of Chinese herbal medicine,acupuncture,auricular acupressure,and other therapies,while the efficacy of acupoint application therapy is receiving increasing attention.

, authors=Honghu LAI1, Xiuxu LU1, Xiaojing LI1, Xinle LI1, Wei SUN1, Hailun XIAO1, Guiji RUAN1, 2, Guangyao LYU1, 2, authorsList=Honghu LAI, Xiuxu LU, Xiaojing LI, Xinle LI, Wei SUN, Hailun XIAO, Guiji RUAN, Guangyao LYU, authorCompany=null, correspAuthors=Guangyao LYU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1315688514470130445, articleId=1315688512674968315, tenantId=1146029695717560320, journalId=1315121837170065538, language=CN, title=中医药治疗围绝经期失眠的CiteSpace可视化分析, columnId=1315688484510221085, journalTitle=中医学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=

目的:分析中医药治疗围绝经期失眠的研究趋势、研究热点,为该领域临床治疗提供参考。方法:检索中国知网(CNKI)、维普资讯(VIP)、万方数据库和中国生物医学文献服务系统(SinoMed)建库以来至2024年6月26日中医药治疗围绝经期失眠相关的研究文献,使用CiteSpace 6.1R6软件对关键词、作者、研究机构进行可视化分析。结果:共纳入相关文献1 401篇,主要涉及作者626位,核心作者以李红、于心同、丁树栋为代表;发文量较高的研究机构为黑龙江中医药大学、成都中医药大学以及广州中医药大学。共纳入关键词608个,高中心性及高频关键词有失眠、绝经期、围绝经期失眠以及针灸等;形成关键词聚类11个,聚类标签包括围绝经期失眠、睡眠障碍、睡眠质量、临床研究等。突现关键词有更年期综合征、中医药疗法、性激素等。结论:我国中医药治疗围绝经期失眠的研究数量正稳步上升,以临床研究为主。围绝经期失眠的中医药治疗研究聚焦于中药、针刺、耳穴压豆等疗法临床疗效,穴位敷贴疗法疗效受到广泛关注。

, authors=赖鸿鹄1, 卢秀煦1, 李小竟1, 李心乐1, 孙炜1, 肖海伦1, 阮贵基1, 2, 吕光耀1, 2, authorsList=赖鸿鹄, 卢秀煦, 李小竟, 李心乐, 孙炜, 肖海伦, 阮贵基, 吕光耀, authorCompany=null, correspAuthors=吕光耀, authorNote=

赖鸿鹄(1998 -),男,广东惠东人,硕士研究生,研究方向:中医药防治脑病的临床与基础研究。

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吕光耀(1970 -),男,教授,主任医师,博士研究生导师。E-mail:
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赖鸿鹄(1998 -),男,广东惠东人,硕士研究生,研究方向:中医药防治脑病的临床与基础研究。

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赖鸿鹄(1998 -),男,广东惠东人,硕士研究生,研究方向:中医药防治脑病的临床与基础研究。

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CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2):242-253., articleTitle=CiteSpace知识图谱的方法论功能, refAbstract=null), Reference(id=1315688526792995690, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, doi=null, pmid=null, pmcid=null, year=2024, volume=42, issue=2, pageStart=9, pageEnd=13, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=邓艾玫, 陈盈颖, 王兰, journalName=中华养生保健, refType=null, unstructuredReference=邓艾玫,陈盈颖,王兰等. 基于CiteSpace的超声在针灸领域应用研究的可视化分析[J]. 中华养生保健, 2024, 42(2):9-13., articleTitle=基于CiteSpace的超声在针灸领域应用研究的可视化分析, refAbstract=null), Reference(id=1315688527032071019, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, doi=null, pmid=null, pmcid=null, year=1993, volume=null, issue=null, pageStart=35, pageEnd=45, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=丁学东, journalName=文献计量学基础, refType=null, unstructuredReference=丁学东. 文献计量学基础[M].北京:北京大学出版社, 1993:35-45., articleTitle=null, refAbstract=null), Reference(id=1315688527401169772, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, doi=null, pmid=null, pmcid=null, year=2012, volume=29, issue=1, pageStart=109, pageEnd=114,92, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=周文杰, 于斌斌, journalName=图书情报知识, refType=null, unstructuredReference=周文杰,于斌斌. 国外认知视角的信息行为研究现状分析:基于文献计量[J]. 图书情报知识, 2012, 29(1):109-114,92., articleTitle=国外认知视角的信息行为研究现状分析:基于文献计量, refAbstract=null), Reference(id=1315688527485055853, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, doi=null, pmid=null, pmcid=null, year=2019, volume=21, issue=12, pageStart=2881, pageEnd=2887, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=张二力, 董宇翔, 黎明全, journalName=世界科学技术:中医药现代化, refType=null, unstructuredReference=张二力,董宇翔,黎明全, 等. 基于CiteSpace的中医传承研究可视化分析[J]. 世界科学技术:中医药现代化, 2019, 21(12):2881-2887., articleTitle=基于CiteSpace的中医传承研究可视化分析, refAbstract=null), Reference(id=1315688527833183086, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, doi=null, pmid=null, pmcid=null, year=2021, volume=23, issue=3, pageStart=953, pageEnd=960, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=田元祥, 刘莎莎, 周新宇, journalName=世界科学技术:中医药现代化, refType=null, unstructuredReference=田元祥,刘莎莎,周新宇, 等. 基于CiteSpace的肝郁脾虚证候诊断标准知识图谱可视化分析[J]. 世界科学技术:中医药现代化, 2021, 23(3):953-960., articleTitle=基于CiteSpace的肝郁脾虚证候诊断标准知识图谱可视化分析, refAbstract=null), Reference(id=1315688527908680559, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, doi=null, pmid=null, pmcid=null, year=2023, volume=34, issue=1, pageStart=148, pageEnd=152, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=韩倩楠, 陈必慧, 朱海利, journalName=海南医学, refType=null, unstructuredReference=韩倩楠,陈必慧,朱海利. 围绝经期女性失眠的中西医治疗思路比较[J]. 海南医学, 2023, 34(1):148-152., articleTitle=围绝经期女性失眠的中西医治疗思路比较, refAbstract=null), Reference(id=1315688528252613488, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, doi=null, pmid=null, pmcid=null, year=2017, volume=37, issue=null, pageStart=193, pageEnd=200, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=YIN X, GOU M H, XU J, journalName=Sleep Med, refType=null, unstructuredReference=YIN X, GOU M H, XU J, et al. Efficacy and safety of acupuncture treatment on primary insomnia:a randomized controlled trial[J]. 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注:节点代表作者,节点越大表示发文量越高;连线代表作者间合作关系,连线越多表示合作越密切。

, figureFileSmall=jFM+4svA59dxzUmLxekdqA==, figureFileBig=pBI1SUuDr2A3IbgDEZQxOA==, tableContent=null), ArticleFig(id=1315688518060454730, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=j4c7PhWcj7ip9q77FPwVvw==, figureFileBig=/BN6iJ35V6ODByxXr6Rgiw==, tableContent=null), ArticleFig(id=1315688518156923723, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=图3, caption=中医药领域治疗围绝经期失眠相关文献发文机构共现图谱

注:节点代表机构,节点越大表示机构发文量越多;连线代表机构间合作关系,连线越多表示合作越密切。

, figureFileSmall=j4c7PhWcj7ip9q77FPwVvw==, figureFileBig=/BN6iJ35V6ODByxXr6Rgiw==, tableContent=null), ArticleFig(id=1315688518265975628, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=j4d5YIkGPM74M/Nio19RBw==, figureFileBig=uacAMt5YcC5lnEEd9m6peA==, tableContent=null), ArticleFig(id=1315688518576354125, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=图4, caption=中医药领域治疗围绝经期失眠相关文献关键词共现图谱

注:节点代表关键词,节点越大代表关键词频次越高;节点连线表示关键词共现关系,连线越粗代表共现强度越高。

, figureFileSmall=j4d5YIkGPM74M/Nio19RBw==, figureFileBig=uacAMt5YcC5lnEEd9m6peA==, tableContent=null), ArticleFig(id=1315688518643462990, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=61+Eq7u5UV32UQmJW1eB+A==, figureFileBig=BWb70cMxU8WP7n0IfUzLxg==, tableContent=null), ArticleFig(id=1315688518727349071, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=图5, caption=基于LLR法的关键词聚类图

注:每个聚类由一种颜色代表,色块面积越大表示聚类包含关键词越多。

, figureFileSmall=61+Eq7u5UV32UQmJW1eB+A==, figureFileBig=BWb70cMxU8WP7n0IfUzLxg==, tableContent=null), ArticleFig(id=1315688519058699088, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=iBoD9tL/0qLebwzsWxCC/g==, figureFileBig=1zc2zbjiUzH1fgkzza0EgQ==, tableContent=null), ArticleFig(id=1315688519427797841, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=图6, caption=中医药领域治疗围绝经期失眠相关文献突现分析

注:红色表明突现开始至结束,红色越长代表突现时间越长;突现强度越大表示受关注程度越高。

, figureFileSmall=iBoD9tL/0qLebwzsWxCC/g==, figureFileBig=1zc2zbjiUzH1fgkzza0EgQ==, tableContent=null), ArticleFig(id=1315688519847228242, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=6BDydfEgfsZebJFNkUTYIQ==, figureFileBig=dOBT5egRvbVJXyLV/cVuig==, tableContent=null), ArticleFig(id=1315688519960474451, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=图7, caption=中医药领域治疗围绝经期失眠相关文献关键词的时线图, figureFileSmall=6BDydfEgfsZebJFNkUTYIQ==, figureFileBig=dOBT5egRvbVJXyLV/cVuig==, tableContent=null), ArticleFig(id=1315688520279241556, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
排序机构数量/篇
1黑龙江中医药大学46
2成都中医药大学44
3广州中医药大学41
4山东中医药大学31
5南京中医药大学22
6福建中医药大学17
7辽宁中医药大学17
8北京中医药大学14
9湖北中医药大学14
10长春中医药大学13
), ArticleFig(id=1315688520690283349, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=表1, caption=

中医药领域治疗围绝经期失眠主要研究机构(前10位)

, figureFileSmall=null, figureFileBig=null, tableContent=
排序机构数量/篇
1黑龙江中医药大学46
2成都中医药大学44
3广州中医药大学41
4山东中医药大学31
5南京中医药大学22
6福建中医药大学17
7辽宁中医药大学17
8北京中医药大学14
9湖北中医药大学14
10长春中医药大学13
), ArticleFig(id=1315688520753197910, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号关键词频次/次中心性首次出现年份
1失眠3410.221991
2围绝经期3210.231991
3围绝经期失眠2590.291991
4针灸2110.221991
5更年期失眠1080.251998
6更年期1070.212000
7失眠症950.172000
8睡眠障碍830.231991
9耳穴压豆800.092005
10睡眠质量680.092016
), ArticleFig(id=1315688521118102359, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=表2, caption=

中医药领域治疗围绝经期失眠相关文献高频关键词(前10位)

, figureFileSmall=null, figureFileBig=null, tableContent=
序号关键词频次/次中心性首次出现年份
1失眠3410.221991
2围绝经期3210.231991
3围绝经期失眠2590.291991
4针灸2110.221991
5更年期失眠1080.251998
6更年期1070.212000
7失眠症950.172000
8睡眠障碍830.231991
9耳穴压豆800.092005
10睡眠质量680.092016
), ArticleFig(id=1315688521533338456, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
模块规模轮廓值年份聚类标签关键词
0750.832013更年期失眠更年期失眠;中医药疗法;酸枣仁汤;二仙汤;入睡和睡眠障碍
1650.8321991围绝经期失眠围绝经期失眠;针刺;围绝经期;针灸;围绝经期失眠症
2650.8152011更年期更年期;失眠症;抑郁;焦虑;不寐
3550.7542009围绝经期围绝经期;耳穴贴压;耳穴压豆;耳穴;临床观察
4510.7072006睡眠障碍睡眠障碍;神经递质;失眠;补肾调肝清心方;影响因素
5490.8442004更年期综合征更年期综合征;中医治疗;中医药治疗;中医辨证;失眠多梦
6440.7562015睡眠质量睡眠质量;围绝经期综合征;中医药;性激素;系统评价
7430.7431999失眠失眠;围绝经期失眠;坤泰胶囊;中药足浴;围绝经期妇女
8340.7932016女性更年期失眠女性更年期失眠;临床效果;疗效;生活质量;中药安神丸
9320.7872015临床研究临床研究;针药结合;心肾不交型;交泰丸;心肾不交
10270.8962017雌二醇雌二醇;穴位贴敷;心理状况;雌激素;促卵泡生成素
), ArticleFig(id=1315688522019877721, tenantId=1146029695717560320, journalId=1315121837170065538, articleId=1315688512674968315, language=CN, label=表3, caption=

中医药领域治疗围绝经期失眠相关文献关键词的聚类分析

, figureFileSmall=null, figureFileBig=null, tableContent=
模块规模轮廓值年份聚类标签关键词
0750.832013更年期失眠更年期失眠;中医药疗法;酸枣仁汤;二仙汤;入睡和睡眠障碍
1650.8321991围绝经期失眠围绝经期失眠;针刺;围绝经期;针灸;围绝经期失眠症
2650.8152011更年期更年期;失眠症;抑郁;焦虑;不寐
3550.7542009围绝经期围绝经期;耳穴贴压;耳穴压豆;耳穴;临床观察
4510.7072006睡眠障碍睡眠障碍;神经递质;失眠;补肾调肝清心方;影响因素
5490.8442004更年期综合征更年期综合征;中医治疗;中医药治疗;中医辨证;失眠多梦
6440.7562015睡眠质量睡眠质量;围绝经期综合征;中医药;性激素;系统评价
7430.7431999失眠失眠;围绝经期失眠;坤泰胶囊;中药足浴;围绝经期妇女
8340.7932016女性更年期失眠女性更年期失眠;临床效果;疗效;生活质量;中药安神丸
9320.7872015临床研究临床研究;针药结合;心肾不交型;交泰丸;心肾不交
10270.8962017雌二醇雌二醇;穴位贴敷;心理状况;雌激素;促卵泡生成素
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中医药治疗围绝经期失眠的CiteSpace可视化分析
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赖鸿鹄 1 , 卢秀煦 1 , 李小竟 1 , 李心乐 1 , 孙炜 1 , 肖海伦 1 , 阮贵基 1, 2 , 吕光耀 1, 2
中医学报 | 临床研究 2025,40(12): 2707-2712
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中医学报 |临床研究 2025 , 40 (12) : 2707 -2712
中医药治疗围绝经期失眠的CiteSpace可视化分析
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赖鸿鹄(1998 -),男,广东惠东人,硕士研究生,研究方向:中医药防治脑病的临床与基础研究。

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赖鸿鹄(1998 -),男,广东惠东人,硕士研究生,研究方向:中医药防治脑病的临床与基础研究。

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赖鸿鹄1, 卢秀煦1, 李小竟1, 李心乐1, 孙炜1, 肖海伦1, 阮贵基1, 2, 吕光耀1, 2
作者信息
  • 1广州中医药大学深圳中西医结合临床医学院,广东 深圳 518104
  • 2深圳市中西医结合医院,广东 深圳 518104
通讯作者:
吕光耀(1970 -),男,教授,主任医师,博士研究生导师。E-mail:
作者简介:

赖鸿鹄(1998 -),男,广东惠东人,硕士研究生,研究方向:中医药防治脑病的临床与基础研究。

CiteSpace Visualization Analysis of Traditional Chinese Medicine Treatment of Perimenopausal Insomnia
Honghu LAI1, Xiuxu LU1, Xiaojing LI1, Xinle LI1, Wei SUN1, Hailun XIAO1, Guiji RUAN1, 2, Guangyao LYU1, 2
Affiliations
  • 1Clinical Medical School, Shenzhen Hospital of Integrative Medicine, Guangzhou University of Chinese Medicine, Shenzhen Guangdong China 518104
  • 2Shenzhen Hospital of Integrative Medicine, Shenzhen Guangdong China 518104
出版时间: 2025-12-10 doi: 10.16368/j.issn.1674-8999.2025.12.420
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目的:分析中医药治疗围绝经期失眠的研究趋势、研究热点,为该领域临床治疗提供参考。方法:检索中国知网(CNKI)、维普资讯(VIP)、万方数据库和中国生物医学文献服务系统(SinoMed)建库以来至2024年6月26日中医药治疗围绝经期失眠相关的研究文献,使用CiteSpace 6.1R6软件对关键词、作者、研究机构进行可视化分析。结果:共纳入相关文献1 401篇,主要涉及作者626位,核心作者以李红、于心同、丁树栋为代表;发文量较高的研究机构为黑龙江中医药大学、成都中医药大学以及广州中医药大学。共纳入关键词608个,高中心性及高频关键词有失眠、绝经期、围绝经期失眠以及针灸等;形成关键词聚类11个,聚类标签包括围绝经期失眠、睡眠障碍、睡眠质量、临床研究等。突现关键词有更年期综合征、中医药疗法、性激素等。结论:我国中医药治疗围绝经期失眠的研究数量正稳步上升,以临床研究为主。围绝经期失眠的中医药治疗研究聚焦于中药、针刺、耳穴压豆等疗法临床疗效,穴位敷贴疗法疗效受到广泛关注。

围绝经期失眠  /  中医药  /  CiteSpace  /  可视化分析

Objective:To analyze the research trends and hotspots of traditional Chinese medicine(TCM)in the treatment of perimenopausal insomnia,providing references for clinical treatment in this field.Methods:Literature related to TCMtreatment of perimenopausal insomnia was retrieved from the China National Knowledge Infrastructure(CNKI),VIP Chinese Science and Technology Journal Database(VIP),Wanfang Database,and China Biomedical Literature Service System(SinoMed)from database inception to June 26,2024. CiteSpace 6.1R6 software was used for visual analysis of keywords,authors,and research institutions.Results:A total of 1 401 related publications were included,involving 626 authors,with core authors represented by Li Hong,Yu Xintong,and Ding Shudong.Research institutions with higher publication output include Heilongjiang University of Chinese Medicine,Chengdu University of Traditional Chinese Medicine,and Guangzhou University of Chinese Medicine.A total of 608 keywords were included,with high centrality and high-frequency keywords including insomnia,menopause,perimenopausal insomnia,and acupuncture.Eleven keyword clusters were formed,with cluster labels including perimenopausal insomnia,sleep disorders,sleep quality,and clinical research.Emerging keywords include menopausal syndrome,traditional Chinese medicine therapies,and sex hormones. Conclusion:Research on treating perimenopausal insomnia with traditional Chinese medicine in China is steadily increasing,mainly focusing on clinical studies.Research on TCMtreatments for perimenopausal insomnia is centered on the clinical efficacy of Chinese herbal medicine,acupuncture,auricular acupressure,and other therapies,while the efficacy of acupoint application therapy is receiving increasing attention.

perimenopausal insomnia  /  traditional Chinese medicine  /  CiteSpace  /  visualization analysis
赖鸿鹄, 卢秀煦, 李小竟, 李心乐, 孙炜, 肖海伦, 阮贵基, 吕光耀. 中医药治疗围绝经期失眠的CiteSpace可视化分析. 中医学报, 2025 , 40 (12) : 2707 -2712 . DOI: 10.16368/j.issn.1674-8999.2025.12.420
Honghu LAI, Xiuxu LU, Xiaojing LI, Xinle LI, Wei SUN, Hailun XIAO, Guiji RUAN, Guangyao LYU. CiteSpace Visualization Analysis of Traditional Chinese Medicine Treatment of Perimenopausal Insomnia[J]. Acta Chinese Medicine, 2025 , 40 (12) : 2707 -2712 . DOI: 10.16368/j.issn.1674-8999.2025.12.420
围绝经期是指女性在接近绝经时至停经后一年的时间段,多为45~55岁[1]。围绝经期是女性的必经阶段[2],在这个特殊的时期,女性会出现包括月经紊乱、烦躁易怒、潮热汗出、失眠多梦、记忆力下降、胸闷心悸、情绪低落等一系列躯体、精神症状,被称为围绝经期综合征[3-5]。统计数据显示,围绝经期失眠是该年龄段女性常见的临床症状,其发病率为42%~54%,可对女性生活质量及情绪造成严重的影响[6]。现代医学多以镇静催眠类药物、激素替代治疗以及心理调节治疗为主,短时间内可改善患者睡眠质量,但长期使用可出现记忆力减退、造成依赖等不良反应[7-8]。失眠归属于中医“目不瞑”“不得卧”“不寐”[9],围绝经期失眠则多属于“绝经前后诸证”“不寐”等范畴,主要以辗转反侧入睡困难或眠浅易醒或多梦易惊,且多伴潮热多汗、心悸胸闷等临床表现[10-11]。围绝经期失眠主要与心、肝、脾、肾相关,主要病机为阳不入阴[12]。中医药充分发挥独特的治疗优势,在围绝经期失眠治疗中取得了良好的疗效,且不易复发,特别是针灸[13-14]。目前,国内外尚无中医药治疗围绝经期失眠的可视化知识图谱。本研究在CiteSpace可视化分析软件基础上,对作者、研究机构、关键词进行可视化分析并绘制相应图谱,挖掘该领域研究热点[15],为今后研究提供参考。
所纳入的研究资料为公开发表的有关围绝经期失眠中医药治疗的论文。检索后得到中国知网文献802篇,万方数据文献1 084篇,维普资讯文献463篇,中国生物医学文献服务系统文献794篇,共计3 143篇文献,将上述文献导入Note Express,经去重、筛选后最终纳入1 401篇。
检索时间为建库至2024年,检索方式为高级检索“主题”,检索策略为“中医or中药or中医药or针灸or针刺”AND“围绝经期or更年期or绝经过渡期or绝经早期”AND“失眠or睡眠障碍or不寐or目不瞑or目不寐”,并将学科限定为“中医学”“中药学”和“中西医结合”。
(1)纳入标准:与中医药治疗围绝经期失眠主题相关的文献,包括临床研究与观察、实验研究、理论探讨、经验总结、研究进展等;文献类型包括学术期刊、学位论文及会议论文;关键词、作者及研究机构信息完整。(2)排除标准:会议通知、图书、专利、成果、征稿通知、科室简介、重复文献等与中医药治疗围绝经期失眠主题不相关的文献;在不同杂志发表的相同标题与作者的文献。
本次研究检索四大中文数据库并进行初步筛选共得到文献3 143篇,将筛选出的文献以Refworks格式导出题录,再将上述文献题录导入Note Express文献管理软件。由2名研究者根据纳入与排除标准独立进行筛选,剔除重复文献,排除关键词、作者及单位信息不全的文献等,交叉核对后纳入文献。对同义关键词进行合并,如:将“临床效果、疗效、治疗效果”合并为“临床疗效”;将“针刺疗法、针刺治疗、针灸治疗、针刺、针灸疗法、中医针灸”合并为“针灸”;研究机构名称规范化,如“湖北中医学院”规范为“湖北中医药大学”,“河南中医学院”规范为“河南中医药大学”等;同一机构不细分学院、科室、部门,如“浙江丽水市中医院中医科”规范为“浙江丽水市中医院”。将规范后的文献题录以Refworks格式导出,命名为“Download_***.txt”。
将文献年度发文量导入Excel 2021,统计文献年度发文量并绘制折线图。将导出的题录导入CiteSpace 6.1R6分析软件对数据转化为CiteSpace可识别的数据格式,Time Slicing设置为For 1900 JAN to 2024 JUN,时间切片设为1年,节点类型分别选择“author(作者)”“institution(机构)”和“keyword(关键词)”,选择Pathfinder + Prunning sliced networks作为数据裁剪算法类型以优化网络,其余选定默认设置。在关键词共现的基础上利用对数似然率(LLR)聚类算法对关键词进行聚类分析,选择Burstness进行关键词突现分析。在上述基础上绘制中医药治疗围绝经期失眠的作者、机构合作情况及关键词共现、聚类、突现的可视化知识图谱,并进行情况分析。
中医药治疗围绝经期失眠相关文献发文时间分布见图1。1991—2011年发展较缓慢,2011—2017年稳步增长,2018—2023年发文量快速增长。2023年是发文量最多的年份,达到177篇。可见该领域发文量整体呈上升趋势,说明中医药领域治疗围绝经期失眠的研究热度逐步上升。其中,2024年仅统计到6月26日,未反映全年的文献量,故发文量较少。
对作者发文量及合作网络进行可视化分析可识别出该领域内的核心作者,并直观对比作者及队伍间合作情况[16]。作者共现及合作网络见图2,共得到作者节点626个,节点连线为424次,其中发文量最高为李红、于心同、丁树栋(各7篇),其次是黄俊山(5篇)。基于普赖斯定律[17-18],N =0.749 ×为核心作者最低发文量公式,其中最大发文量ηmax =7,通过计算可得N≈2篇,表示发文量≥2篇的作者为该研究领域的核心作者,统计共188位核心作者,发表量共计达437篇,约为纳入文献总量的70%,说明该领域已形成核心作者群,是以李红、张娅、黄俊山、任秀亚、徐莲薇、陈燕芬、杜彩凤为主的多个核心研究团队。
研究机构合作网络分析图可见图3,共包括483所研究机构,主要包括黑龙江中医药大学、成都中医药大学以及广州中医药大学等。机构之间连线较少,仅涉及57个合作,网络密度为0.000 5,表明机构之间的研究较为独立,较少跨区、跨机构的合作,主要集中在中医药大学及其附属医院,如山东中医药大学及其附属医院,黑龙江中医药大学及其附属医院均有合作。发文量排名前10位的研究机构可见表1,其中黑龙江中医药大学以46篇的发文量位居榜首,成都中医药大学(44篇)、广州中医药大学(41篇)紧随其后。
关键词是对相关领域文献研究主要方向和核心内容的展现,可直观反映该领域的主要研究内容和热点[19]。出现频次前10位的高频关键词见表2。一般而言,中心性≥0.1的节点可当作是关键节点,共有18个关键词中心性≥0.1,频次≥20次的关键词有23个。中心性及频次较高的关键词有失眠、绝经期、围绝经期失眠以及针灸等。关键词共现网络见图4。该图谱有608个节点、1 626条连线,网络密度为0.008 8。由图4可知,围绝经期失眠对围绝经期女性产生严重的影响,是围绝经期综合征的主要症状之一,并伴随焦虑抑郁的产生。黄连阿胶汤、酸枣仁汤是治疗失眠的主要方剂,也是中医治疗失眠的热点。除中药外,针灸及耳穴压豆也是中医治疗失眠的重要方法,近年来的研究热点以针灸为主。
关键词共形成11个聚类,包括“#1围绝经期失眠”“#4睡眠质量”“#5更年期综合征”“#8女性更年期失眠”等。评判关键词聚类图谱绘制效果,可依据聚类的模块值(Modularity,Q值)与平均轮廓值(Mean Silhouette,S值)。Q值>0.3表示聚类结果显著合理,S值≥0.7则表示聚类结果可信[20]。该图谱模块聚类值为0.555 5,聚类平均轮廓值为0.803 9,认为本聚类结果合理可信,见图5。
#0包括中医药疗法、酸枣仁汤、二仙汤;#5包括中医治疗、中医药治疗、中医辨证等关键词,研究内容为中医辨证用药及代表方;#1包括针刺、针灸;#3包括耳穴贴压、耳穴压豆、耳穴;#7包括坤泰胶囊、中药足浴;#10包括穴位贴敷等关键词,研究内容为中成药及中医外治法治疗围绝经期失眠临床观察及经验总结,治疗以针灸及耳穴压豆为主;#6包括睡眠质量、系统评价;#8包括临床效果、疗效、生活质量;#9包括临床研究、针药结合等关键词,研究内容为临床对照试验及有效性、安全性评估,见表3。
围绝经期失眠的突现关键词见图6。1991年至今突现关键词有“更年期综合征”“更年期”“中医药疗法”“更年期失眠”“睡眠质量”“性激素”。图6显示,围绝经期失眠作为围绝经期失眠的症状之一成为1991年至2015年的研究热点。2016至2024年“睡眠质量”为研究重点,表明随着人们生活节奏的加快及生活压力的升高,更年期女性睡眠质量越来越受到关注。
关键词“围绝经期、围绝经期失眠、失眠、睡眠障碍”出现时间最早,时间跨度高,至今依旧是主要研究热点。随后名医经验总结兴起并成为研究热点,研究者们对经方及验方进行临床研究与观察;研究者致力于《伤寒论》《金匮要略》《傅青主女科》等经典古籍中对围绝经期失眠的治疗,见图7。
随着社会节奏的加快,人文环境的变化,女性社会压力、家庭压力以及生育压力与日俱增[21]。围绝经期失眠作为围绝经期综合症状之一出现,困扰39%~47%的围绝经期女性[22]。
本研究发现,围绝经期失眠的研究文献年发文量总体呈上升趋势,2011—2017稳步增长,2018—2023年发文量快速增长,2023年发文量最高(177篇),表明越来越多研究者对围绝经期失眠进行研究,且研究方向以临床疗效观察为主。作者共现及合作网络图分析可知,该领域已形成以李红、张娅、黄俊山、任秀亚、徐莲薇、陈燕芬、杜彩凤为主的多个核心作者群。张娅、黄俊山团队研究集中在围绝经期失眠的证候分布特点及肾虚肝郁型围绝经期失眠患者的中药治疗临床研究等方面。徐莲薇团队研究集中在滋肾平肝结合情志疗法治疗围绝经期失眠方面。中医药治疗围绝经期失眠相关研究的主要研究单位是中医药高校及其附属医院,黑龙江中医药大学(46篇)、成都中医药大学(44篇)、广州中医药大学(41篇)。从研究机构合作图谱可得,研究机构之间连线较少,网络密度仅为0.000 5,表明该领域跨机构合作较少,机构之间的研究较为独立,可增强机构之间的交流与合作。
通过分析关键词共现、聚类、突现图谱及聚类时间线图,可直观展示中医药治疗围绝经期失眠的历史演进及研究热点。关键词共现分析方面,中心性及频次较高的关键词有失眠、绝经期、围绝经期失眠、针灸以及耳穴压豆等,表明针灸及耳穴压豆为治疗围绝经期失眠的主要治疗手段,而黄连阿胶汤、酸枣仁汤是治疗失眠的主要方剂。分析11个聚类信息提示研究内容主要包括为围绝经期失眠的中医辨证用药及代表方、相关治疗的临床观察及经验总结、临床对照试验及有效性、安全性评估等方面。结合关键词突现分析可进一步预测当前的研究热点,“睡眠质量”成为近期的研究热点。
(1)目前的研究仍以临床疗效观察以及临床研究为主,但受到一定临床条件的限制,为了形成高质量、可信度高的临床对照试验报告,仍需各位研究者加强临床研究设计,使研究更加合理化。此外,围绝经期失眠的基础研究相对较少,机制研究方面较为薄弱。(2)本领域中作者合作相对紧密,已形成几个核心作者群,然而机构之间合作不紧凑,只局限于中医药大学及其附属医院之间[23],应提倡跨院校、跨区域合作交流,增强研究的深度,拓宽研究的范围,促进大样本、多中心的研究,为基础研究奠定基础。(3)本研究使用的CiteSpace可视化分析软件需要一定的步骤对原始数据进行转化才能进一步识别,因此其准确性尚有待考证。(4)不同的参数设置可导致数据结果及可视化图谱有所差异,然而参数的设置过程受人为因素的影响,因此往往会展现出不同的结果。(5)本研究仅选择中文数据库中的四大数据库,未把其他中文数据库及外文数据库纳入,今后可将上述数据库均纳入,以此进行更加全面广泛的可视化分析,提高结果的准确性,更好地为围绝经期失眠的临床诊治与研究提供借鉴。

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doi: 10.16368/j.issn.1674-8999.2025.12.420
  • 接收时间:2025-07-19
  • 首发时间:2026-10-10
  • 出版时间:2025-12-10
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  • 收稿日期:2025-07-19
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    1广州中医药大学深圳中西医结合临床医学院,广东 深圳 518104
    2深圳市中西医结合医院,广东 深圳 518104

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吕光耀(1970 -),男,教授,主任医师,博士研究生导师。E-mail:
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
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占总种数比例
Percentage of
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属
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Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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