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Research progress on stabilization mechanism of TCM volatile oil
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Qi-lin GUAN1, 4, Liang-shan MING1, 2, Zhi-jian ZHONG1, 3, Pan DENG1, 3, Ke PENG1, 3, Yong-mei GUAN1, Wen-ting WU1, Zhe LI1, 4, *, Wei-feng ZHU1, *
Chinese Journal of Traditional Chinese Medicine | 2026, 51(2) : 400 - 412
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(2): 400-412
Research progress on stabilization mechanism of TCM volatile oil
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Qi-lin GUAN1, 4, Liang-shan MING1, 2, Zhi-jian ZHONG1, 3, Pan DENG1, 3, Ke PENG1, 3, Yong-mei GUAN1, Wen-ting WU1, Zhe LI1, 4, *, Wei-feng ZHU1, *
Affiliations
  • 1.Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2.Advanced Research Institute, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 3.Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330096, China
  • 4.Jiangxi Provincial Key Laboratory of Chinese Medicine Improvement and Innovation, Nanchang 330004, China
Published: 2026-01-15 doi: 10.19540/j.cnki.cjcmm.20251021.301
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TCM volatile oil exhibits excellent biological activities and wide application scenarios. However, its volatility and susceptibility to oxidation and deterioration severely restrict the quality of its preparations and clinical efficacy. Therefore, stabilizing TCM volatile oil is extremely necessary. Current research mainly focuses on the development of stabilization techniques and carrier materials, aiming to enhance its stability and endow it with sustained-release and controlled-release properties. In recent years, researchers have increasingly paid attention to the intrinsic mechanisms and potential interactions during the stabilization process, which is of great significance for the development of new stabilization technologies for volatile oil and the research on new dosage forms containing volatile oil. This article systematically reviews the mechanisms of action during the stabilization of TCM volatile oil and summarizes the key methods for characterizing interactions, with the aim of providing references for the development of new stabilization technologies for TCM volatile oil and the theoretical research on its stabilization.

TCM volatile oil  /  stabilization  /  hydrogen bond  /  van der Waals force  /  chemical bond  /  hydrophobic interaction
Qi-lin GUAN, Liang-shan MING, Zhi-jian ZHONG, Pan DENG, Ke PENG, Yong-mei GUAN, Wen-ting WU, Zhe LI, Wei-feng ZHU. Research progress on stabilization mechanism of TCM volatile oil[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (2) : 400 -412 . DOI: 10.19540/j.cnki.cjcmm.20251021.301
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doi: 10.19540/j.cnki.cjcmm.20251021.301
  • Receive Date：2025-07-28
  • Online Date：2026-06-25
  • Published：2026-01-15
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  • Received：2025-07-28
Funding
Affiliations
    1.Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    2.Advanced Research Institute, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    3.Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330096, China
    4.Jiangxi Provincial Key Laboratory of Chinese Medicine Improvement and Innovation, Nanchang 330004, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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