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Application of combination of traditional Chinese medicine and western medicine in epilepsy prevention and treatment
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Yuan YAO1, Xue-pin WANG2, Rui-fan LIN2, Wen-ya GAO2, *, Hong-wei ZHOU1, Qi XIE2
Chinese Journal of Traditional Chinese Medicine | 2026, 51(1) : 56 - 63
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(1): 56-63
Application of combination of traditional Chinese medicine and western medicine in epilepsy prevention and treatment
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Yuan YAO1, Xue-pin WANG2, Rui-fan LIN2, Wen-ya GAO2, *, Hong-wei ZHOU1, Qi XIE2
Affiliations
  • 1.National Data Center of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
Published: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20251011.501
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Epilepsy is a common neurological disorder characterized by refractoriness and recurrence. In China, the prevalence rate is 0.4%-0.7%, with currently over nine million patients, among whom approximately 30% suffer from refractory epilepsy. Although antiepileptic drugs (AEDs) are the mainstay of treatment, they are associated with multi-system adverse reactions and drug resistance issues. In contrast, traditional Chinese medicine (TCM) treatment exhibits significant efficacy with lower toxicity and side effects, and integrated TCM and western medicine treatment can achieve complementary advantages. Studies have shown that integrated therapy demonstrates benefits in various types of epilepsy, including status epilepticus, post-stroke epilepsy, post-traumatic epilepsy, pediatric epilepsy, refractory epilepsy, and epilepsy comorbid with depression and anxiety. It exerts synergistic effects by enhancing AED bioavailability (borneol improves blood-brain barrier permeability), reducing seizure frequency, preventing recurrence, and minimizing western medicine toxicity (Dingxian Decoction decreases digestive/neurological adverse reactions). The underlying mechanisms involve regulating neurotransmitters (modulating glutamate and γ-aminobutyric acid levels) and ion channels (inhibiting sodium/calcium ion channels). In terms of preventive care, TCM plays an important role in preventing epileptic seizures by correcting biased constitutional states. In the future, integrated TCM and western medicine in epilepsy prevention and treatment will move toward individualized treatment, etiological treatment, preventive rehabilitation, and integration of scientific research with clinical practice, forming a three-dimensional development pattern of "technology empowerment, standard guidance, and whole-process management".

combination of traditional Chinese medicine and western medicine  /  epilepsy prevention and treatment  /  neurotransmitter  /  ion channel  /  etiology of epilepsy  /  individualized treatment
Yuan YAO, Xue-pin WANG, Rui-fan LIN, Wen-ya GAO, Hong-wei ZHOU, Qi XIE. Application of combination of traditional Chinese medicine and western medicine in epilepsy prevention and treatment[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 56 -63 . DOI: 10.19540/j.cnki.cjcmm.20251011.501
Year 2026 volume 51 Issue 1
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doi: 10.19540/j.cnki.cjcmm.20251011.501
  • Receive Date:2025-07-02
  • Online Date:2026-06-25
  • Published:2026-01-01
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  • Received:2025-07-02
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    1.National Data Center of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
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表12种不同金属材料的力学参数

Family
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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