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TCM regulates endothelial-to-mesenchymal transition in treatment of atherosclerosis: a review
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Xue-yan ZHANG1, Ying-zhu DUAN1, You YU2, Huan ZHANG1, Jiao-dan WANG1, Xin-ran GENG1, Rui YU1, *
Chinese Journal of Traditional Chinese Medicine | 2026, 51(1) : 50 - 55
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(1): 50-55
TCM regulates endothelial-to-mesenchymal transition in treatment of atherosclerosis: a review
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Xue-yan ZHANG1, Ying-zhu DUAN1, You YU2, Huan ZHANG1, Jiao-dan WANG1, Xin-ran GENG1, Rui YU1, *
Affiliations
  • 1.Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China
  • 2.the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China
Published: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20250929.801
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Endothelial-to-mesenchymal transition (EndMT) is a process in which endothelial cells lose specific markers and acquire a mesenchymal phenotype under pathological stimulation, contributing to the occurrence and progression of atherosclerosis (AS). Recent studies have shown that TCM, with its unique advantages of holism and treatment based on syndrome differentiation, can inhibit AS by regulating EndMT-related signaling pathways at multiple levels, through multiple pathways and targets. This article systematically reviews the mechanisms of EndMT in AS, as well as the research progress of TCM monomers and compounds in counteracting AS via EndMT intervention, providing new ideas and a scientific basis for the prevention and treatment of AS with TCM.

atherosclerosis  /  endothelial-to-mesenchymal transition  /  traditional Chinese medicine  /  research progress
Xue-yan ZHANG, Ying-zhu DUAN, You YU, Huan ZHANG, Jiao-dan WANG, Xin-ran GENG, Rui YU. TCM regulates endothelial-to-mesenchymal transition in treatment of atherosclerosis: a review[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 50 -55 . DOI: 10.19540/j.cnki.cjcmm.20250929.801
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Year 2026 volume 51 Issue 1
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doi: 10.19540/j.cnki.cjcmm.20250929.801
  • Receive Date：2025-09-01
  • Online Date：2026-06-25
  • Published：2026-01-01
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  • Received：2025-09-01
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    1.Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China
    2.the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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