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Research progress in neuroprotective effects of Bacopa monnieri active components and derivatives in neurological disorders
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Lyu-yuan LIANG1, 2, Jia-lei CAO1, 2, Zi-lin ZHAO2, Yi-fan QI2, Yan-hua WANG1, 2, Shang-ming FANG2, Shuai-bin DONG2, Yun-kai WANG3, Xiang-han TAN4, Bing-qi WEI5, Bing-xiang MA1, 2, *, Jie-qiong CUI1, 2, *
Chinese Journal of Traditional Chinese Medicine | 2026, 51(1) : 40 - 49
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(1): 40-49
Research progress in neuroprotective effects of Bacopa monnieri active components and derivatives in neurological disorders
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Lyu-yuan LIANG1, 2, Jia-lei CAO1, 2, Zi-lin ZHAO2, Yi-fan QI2, Yan-hua WANG1, 2, Shang-ming FANG2, Shuai-bin DONG2, Yun-kai WANG3, Xiang-han TAN4, Bing-qi WEI5, Bing-xiang MA1, 2, *, Jie-qiong CUI1, 2, *
Affiliations
  • 1.Pediatric Hospital of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450099, China
  • 2.School of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 3.Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, China
  • 4.Weill Cornell Medicine, Cornell University, New York 10065, USA
  • 5.Henan Province Hospital of Traditional Chinese Medicine (the Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou 450002, China
Published: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20251011.703
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Bacopa monnieri, a plant of Scrophulariaceae, has a long history of medicinal use and is recognized as a traditional medicinal herb in multiple countries. Neurological disorders, due to their extensive damage to neural functions, have become a major public health challenge and garnered worldwide attention. In ancient times, B. monnieri was documented for treating cognitive and memory impairments. Recent studies have elucidated its pharmacological mechanisms and therapeutic targets underpinning the neuroprotective effect. However, the molecular mechanisms of its active ingredients have not been systematically summarized. This study is the first to integrate the target sites of its core ingredients across multiple categories of neurological disorders. It summarizes the pharmacological mechanisms of B. monnieri as well as its active ingredients and derivatives in various neurological diseases, which exert neuroprotective effects through multi-target interactions. This paper provides novel strategies for developing botanical drugs targeting diseases like Alzheimer's and epilepsy and aims to offer evidence-based guidance for the development and application of B. monnieri in functional foods, health supplements, and pharmaceuticals.

Bacopa monnieri  /  active ingredients  /  neurological disorders  /  neurodegenerative diseases  /  neurodevelopmental disorders  /  pharmacological effects
Lyu-yuan LIANG, Jia-lei CAO, Zi-lin ZHAO, Yi-fan QI, Yan-hua WANG, Shang-ming FANG, Shuai-bin DONG, Yun-kai WANG, Xiang-han TAN, Bing-qi WEI, Bing-xiang MA, Jie-qiong CUI. Research progress in neuroprotective effects of Bacopa monnieri active components and derivatives in neurological disorders[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 40 -49 . DOI: 10.19540/j.cnki.cjcmm.20251011.703
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Article Info
doi: 10.19540/j.cnki.cjcmm.20251011.703
  • Receive Date：2025-08-26
  • Online Date：2026-06-25
  • Published：2026-01-01
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History
  • Received：2025-08-26
Funding
Affiliations
    1.Pediatric Hospital of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450099, China
    2.School of Pediatrics, Henan University of Chinese Medicine, Zhengzhou 450046, China
    3.Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, China
    4.Weill Cornell Medicine, Cornell University, New York 10065, USA
    5.Henan Province Hospital of Traditional Chinese Medicine (the Second Affiliated Hospital of Henan University of Chinese Medicine), Zhengzhou 450002, China
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https://castjournals.cast.org.cn/joweb/zgzyzz/EN/10.19540/j.cnki.cjcmm.20251011.703
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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