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Application progress of germ-free animal models in colorectal cancer and traditional Chinese medicine research
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Zi-xing QIAN1, 2, Jia-xuan LI1, 2, Xian-jun RAO2, Guo-dong HUANG2, Ran LIU2, Wei WEI1, 2, *
Chinese Journal of Traditional Chinese Medicine | 2026, 51(1) : 32 - 39
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(1): 32-39
Application progress of germ-free animal models in colorectal cancer and traditional Chinese medicine research
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Zi-xing QIAN1, 2, Jia-xuan LI1, 2, Xian-jun RAO2, Guo-dong HUANG2, Ran LIU2, Wei WEI1, 2, *
Affiliations
  • 1.Hubei University of Chinese Medicine, Wuhan 430065, China
  • 2.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
Published: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20251011.708
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Colorectal cancer (CRC) is a highly prevalent malignant tumor worldwide, and its occurrence and development are closely related to gut microbiota disturbance. The germ-free (GF) animal model, by providing a unique environment free of indigenous microorganisms, has become a tool for precisely dissecting the causal role and mechanism of the gut microbiota in the occurrence and development of CRC and the therapeutic mechanisms of pharmaceuticals. This review aims to systematically elaborate on the application progress of GF animal models in CRC research, with a focus on the key mechanisms by which specific microorganisms promote the occurrence and development of CRC revealed by this model. Furthermore, this review focuses on the research dynamics of TCM in this field and systematically expounds the application of GF models in the research of TCM against CRC. Through in-depth analysis of the GF animal models of CRC, it is possible to develop precise diagnostic and therapeutic strategies based on TCM and the microbiome in the future, providing new directions and ideas for the prevention and treatment of CRC.

germ-free animals  /  gut microbiota  /  traditional Chinese medicine  /  colorectal cancer
Zi-xing QIAN, Jia-xuan LI, Xian-jun RAO, Guo-dong HUANG, Ran LIU, Wei WEI. Application progress of germ-free animal models in colorectal cancer and traditional Chinese medicine research[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 32 -39 . DOI: 10.19540/j.cnki.cjcmm.20251011.708
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doi: 10.19540/j.cnki.cjcmm.20251011.708
  • Receive Date：2025-09-17
  • Online Date：2026-06-25
  • Published：2026-01-01
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  • Received：2025-09-17
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Affiliations
    1.Hubei University of Chinese Medicine, Wuhan 430065, China
    2.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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