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Chemical constituents from stem bark of Aquilaria yunnanensis and their anti-inflammatory activities
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Li-lin ZHENG1, 2, 3, Dong-bao HU4, Jun YANG2, 3, Ya-jun HAN2, Qing-hua KONG2, Xiao-yan DUAN2, Ji-feng LUO2, Yun-song WANG1, Jing-hua YANG1, *, Yue-hu WANG2, 3, *
Chinese Journal of Traditional Chinese Medicine | 2026, 51(1) : 103 - 113
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(1): 103-113
Chemical constituents from stem bark of Aquilaria yunnanensis and their anti-inflammatory activities
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Li-lin ZHENG1, 2, 3, Dong-bao HU4, Jun YANG2, 3, Ya-jun HAN2, Qing-hua KONG2, Xiao-yan DUAN2, Ji-feng LUO2, Yun-song WANG1, Jing-hua YANG1, *, Yue-hu WANG2, 3, *
Affiliations
  • 1.Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
  • 2.Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
  • 3.Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation, Xishuangbanna 666100, China
  • 4.School of Chemical Biology and Environment, Yuxi Normal University, Yuxi 653100, China
Published: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20251104.201
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The stem bark of Aquilaria yunnanensis (Thymelaeaceae) is traditionally used to treat cough and asthma in folk medicine. However, its active components have not been reported. In the present study, the chemical constituents of A. yunnanensis stem bark were isolated and identified, and their inhibitory activities against nitric oxide (NO) production in RAW264.7 cells induced by lipopolysaccharide (LPS) were evaluated to clarify the anti-inflammatory components in the stem bark of A. yunnanensis. A total of 22 compounds, including a new norlignan [(±)-1], were isolated from the ethanolic extract of A. yunnanensis stem bark by column chromatography, high-performance liquid chromatography (HPLC), recrystallization, etc. Through chiral separation of (±)-1, (-)-1 and (+)-1 were obtained. Based on electronic circular dichroism (ECD) calculations, the absolute configurations of (-)-1 and (+)-1 were determined to be (-)-(7R, 8S, 8′S)-4-O- (1, 3-dihydroxypropan-2-yl) zhebeiresinol and (+)-(7S, 8R, 8′R)-4-O- (1, 3-dihydroxypropan-2-yl) zhebeiresinol. The known compounds included (±)-zhebeiresinol (2), (+)-syringaresinol (3), (+)-episyringaresinol (4), orcinol (5), orsellinic acid (6), methyl orsellinate (7), 3, 4-dihydroxybenzoic acid (8), lecanoric acid (9), barbatic acid (10), 7β-hydroxy-β-sitosterol (11), β-sitosterol (12), stigmasterol (13), ergosterol peroxide (14), genkwanin (15), pilloin (16), 5-hydroxy-3′, 4′, 7-trimethoxyflavone (17), (-)-epicatechin (18), (-)-epicatechin gallate (19), tectorigenin 2-O-α-L-rhamnopyranoside (20), 2, 3-dihydroxypropyl docosanoate (21), and 1-O-linolenoylglycerol (22). According to the bioassay testing results, compounds 4 and 22 which inhibited NO production with IC50 values of (32.82±1.04) and (18.50±0.95) μmol·L-1, respectively, exhibited anti-inflammatory activities.

Thymelaeaceae  /  Aquilaria  /  Aquilaria yunnanensis  /  cough and asthma  /  anti-inflammatory activities
Li-lin ZHENG, Dong-bao HU, Jun YANG, Ya-jun HAN, Qing-hua KONG, Xiao-yan DUAN, Ji-feng LUO, Yun-song WANG, Jing-hua YANG, Yue-hu WANG. Chemical constituents from stem bark of Aquilaria yunnanensis and their anti-inflammatory activities[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 103 -113 . DOI: 10.19540/j.cnki.cjcmm.20251104.201
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doi: 10.19540/j.cnki.cjcmm.20251104.201
  • Receive Date：2025-06-21
  • Online Date：2026-06-25
  • Published：2026-01-01
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History
  • Received：2025-06-21
Funding
Affiliations
    1.Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
    2.Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
    3.Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation, Xishuangbanna 666100, China
    4.School of Chemical Biology and Environment, Yuxi Normal University, Yuxi 653100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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