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Two new alkaloids from Corydalis delicatula
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Xin-yue HUANG1, Shao-wen XIONG1, Yuan-fei LI1, Yu-chen JIANG1, Jia CUI1, Kang LI2, Li-mei LI1, *
Chinese Journal of Traditional Chinese Medicine | 2026, 51(1) : 114 - 120
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(1): 114-120
Two new alkaloids from Corydalis delicatula
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Xin-yue HUANG1, Shao-wen XIONG1, Yuan-fei LI1, Yu-chen JIANG1, Jia CUI1, Kang LI2, Li-mei LI1, *
Affiliations
  • 1.College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China
  • 2.High Altitude Medical Research Institute, People's Hospital of Xizang Autonomous Region, Lhasa 850000, China
Published: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20251010.201
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In this study, the total alkaloids of Corydalis delicatula were isolated and purified by a combination of silica gel, aluminum oxide basic column chromatography and other chromatographic techniques. The obtained compounds were structurally identified with the help of modern spectral resolution techniques such as nuclear magnetic resonance (1D/2D NMR), high-resolution mass spectrometry (HR-ESI-MS), and single crystal X-ray diffraction. Nine alkaloids were obtained from the total alkaloids of C. delicatula, encompassing two new compounds, corlicatine (1) and N-methyl-13-oxoprotopine (2), and seven known ones: (+)-ochotensine (3), rupestrine A (4), (+)-ochotensimine (5), oxohydrastinine (6), α-magnoflorine (7), 6, 7-methylenedioxy-N-methylisoquinoline (8), and N-methyl-6, 7-dimethoxyisoquinoline (9). The inhibitory activities of the compounds against acetylcholinesterase were evaluated, with compound 4 exhibiting moderate inhibition. Molecular docking was further performed to elucidate the binding mode of this compound. The results provide a basis for elucidating the medicinal substance basis of C. delicatula.

Corydalis delicatula  /  Corydalis  /  alkaloid  /  corlicatine  /  N-methyl-13-oxoprotopine
Xin-yue HUANG, Shao-wen XIONG, Yuan-fei LI, Yu-chen JIANG, Jia CUI, Kang LI, Li-mei LI. Two new alkaloids from Corydalis delicatula[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 114 -120 . DOI: 10.19540/j.cnki.cjcmm.20251010.201
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Year 2026 volume 51 Issue 1
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doi: 10.19540/j.cnki.cjcmm.20251010.201
  • Receive Date：2025-07-17
  • Online Date：2026-06-25
  • Published：2026-01-01
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  • Received：2025-07-17
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    1.College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China
    2.High Altitude Medical Research Institute, People's Hospital of Xizang Autonomous Region, Lhasa 850000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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