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Secondary metabolites from Rhododendron molle endophyte Penicillium sp. RM and their inhibitory effects on tumor cell proliferation
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Xue WANG1, Lei ZHOU1, Yi-hang HU1, Yang LIU2, Xue ZHANG1, *, Yun-bao LIU2, *
Chinese Journal of Traditional Chinese Medicine | 2026, 51(2) : 444 - 449
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Chinese Journal of Traditional Chinese Medicine | 2026, 51(2): 444-449
Secondary metabolites from Rhododendron molle endophyte Penicillium sp. RM and their inhibitory effects on tumor cell proliferation
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Xue WANG1, Lei ZHOU1, Yi-hang HU1, Yang LIU2, Xue ZHANG1, *, Yun-bao LIU2, *
Affiliations
  • 1.School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2026-01-15 doi: 10.19540/j.cnki.cjcmm.20251009.202
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This study investigated the secondary metabolites of the endophytic fungus Penicillium sp. RM isolated from the toxic plant Rhododendron molle. Ten compounds were isolated and purified from the ethyl acetate extract of the fungal fermentation broth by silica gel column chromatography, gel column chromatography, and semi-preparative HPLC. The structures of these compounds were elucidated by comprehensive spectroscopic analyses, including NMR, MS, UV, IR, and CD. The identified compounds were as follows: penicidienone A (1), diversonol (2), alternariol (3), alternariol 9-methyl ether (4), methylated dechloromonilicin (5), norliquexantona (6), alternethanoxin A (7), α-diversonolic ester (8), (±) -asperlone A (9), and verruculotoxin (10). Compound 1 was identified as a new cyclopentenone derivative. Compound 9 showed inhibitory activity against the proliferation of HepG2 (IC50=9.7 μmol·L-1), HGC27 (IC50 = 9.3 μmol·L-1), and U251 (IC50 = 8.4 μmol·L-1) cell lines.

Rhododendron molle  /  endophytic fungi  /  Penicillium sp. RM  /  secondary metabolites  /  cyclopentenone derivative
Xue WANG, Lei ZHOU, Yi-hang HU, Yang LIU, Xue ZHANG, Yun-bao LIU. Secondary metabolites from Rhododendron molle endophyte Penicillium sp. RM and their inhibitory effects on tumor cell proliferation[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (2) : 444 -449 . DOI: 10.19540/j.cnki.cjcmm.20251009.202
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Year 2026 volume 51 Issue 2
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doi: 10.19540/j.cnki.cjcmm.20251009.202
  • Receive Date：2025-05-27
  • Online Date：2026-06-25
  • Published：2026-01-15
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  • Received：2025-05-27
Affiliations
    1.School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
    2.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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https://castjournals.cast.org.cn/joweb/zgzyzz/EN/10.19540/j.cnki.cjcmm.20251009.202
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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