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Article(id=1276976168536502372, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20250905.703, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753113600000, receivedDateStr=2025-07-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384443648, onlineDateStr=2026-06-25, pubDate=1768406400000, pubDateStr=2026-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384443648, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384443648, creator=13701087609, updateTime=1782384443648, updator=13701087609, issue=Issue{id=1276976057215488893, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='2', pageStart='301', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1768406400000', pubDateStr='2026-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782384417107, creator='13701087609', updateTime=1782384524478, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976507658563977, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976507658563978, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=493, endPage=504, ext={EN=ArticleExt(id=1276976168767189094, articleId=1276976168536502372, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Mechanism of Quzhou Aurantii Fructus in treating rats with functional dyspepsia based on gut microbiota and metabolomics, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

The therapeutic effects of Quzhou Aurantii Fructus aqueous extract (QAFA) and Aurantii Fructus aqueous extract (AFA) on functional dyspepsia (FD) in rats were evaluated and compared, and their underlying mechanisms were investigated. The FD rat models were constructed by a combined method of "pinching tail + irregular diet + drinking dilute acidic water". The rats were orally administered QAFA at a dose of 2.05 g·kg-1(equivalent to 4 g·kg-1 QAF) and AFA at a dose of 1.93 g·kg-1(equivalent to 4 g·kg-1 AF), respectively. After 14-day administration, the gastric emptying and intestinal propulsion were assessed. The pathological changes in the gastric antrum and duodenum were analyzed via histology, and the levels of serum gastrin (GAS) and vasoactive intestinal polypeptide (VIP) were measured by enzyme-linked immunosorbent assay. The underlying mechanisms were investigated by using 16S rRNA sequencing and serum metabolomics. The results showed that QAFA and AFA could increase gastrointestinal motility. Hematoxylin-eosin (HE) staining and immunofluorescence analysis showed that both QAFA and AFA repaired the damaged intestinal barrier, and ELISA analysis showed that they regulated GAS and VIP levels in serum. These results suggest that both can improve symptoms in FD rats. The intestinal microbiota analysis revealed that QAFA and AFA reduced the abundance of the harmful microbe Ruminococcus. AFA increased the abundance of the beneficial bacteria Prevotella and Lactobacillus, and QAFA increased the abundance of Clostridia UCG-014. Metabolomic analysis showed that both QAFA and AFA restored serum metabolites primarily through regulating phospholipid metabolism. Correlation analysis between metabolites and gut microbiota showed that both QAFA and AFA decreased the abundance of Ruminococcus, and AFA increased the abundance of Prevotella, thereby restoring serum metabolite levels. These findings suggest that QAFA and AFA may improve FD symptoms in rats by modulating specific gut microbiota to restore gastrointestinal hormones and phospholipid metabolism. However, there are some differences in the specific microbiotas they regulate.

, authors=null, authorsList=Wen-kang HUANG, Qi-xin ZHANG, Xiao-tong LIU, Mei-zi TIAN, Hai-ou WANG, Jia-hui CHEN, Li-juan GAO, Hong-xiang SUN, Jue TU, Li-xia WANG, Yi-ping YE, authorCompany=null, correspAuthors=Li-xia WANG, Yi-ping YE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976169094344808, articleId=1276976168536502372, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=基于肠道菌群和代谢组学探讨衢枳壳治疗功能性消化不良大鼠的作用机制, columnId=1276975994707775974, journalTitle=中国中药杂志, columnName=药理, runingTitle=null, highlight=null, articleAbstract=

评价和比较衢枳壳水提物（QAFA）和枳壳水提物（AFA）对功能性消化不良（FD）的治疗效果，并探讨其作用机制。以“夹尾+不规则饮食+稀酸水饮用”联合造模法构建FD大鼠模型。分别灌胃给予QAFA 2.05 g·kg-1（相当于衢枳壳4 g·kg-1）、AFA 1.93 g·kg-1（相当于枳壳4 g·kg-1），连续给药14 d后，测定胃排空率和小肠推进率；组织学分析胃窦和十二指肠组织的病理变化；ELISA法检测血清中胃泌素（GAS）和血管活性肠肽（VIP）的水平；利用16S rRNA测序和血清代谢组学探讨其潜在机制。结果显示，QAFA和AFA可增加胃肠动力；苏木精-伊红染色和免疫荧光分析显示，QAFA和AFA均可修复损伤的肠道屏障；ELISA结果显示均可调节血清中GAS和VIP水平，表明两者均可改善FD大鼠症状。肠道菌群分析显示，QAFA和AFA均降低了有害菌瘤胃球菌属Ruminococcus的丰度，而AFA同时增加了有益菌普雷沃菌属Prevotella和乳杆菌属Lactobacillus的丰度，QAFA则提高了Clostridia UCG-014的丰度。代谢组学分析显示，QAFA和AFA主要通过调节磷脂代谢来恢复血液中的代谢物水平。肠道菌群与代谢产物相关性分析显示QAFA和AFA均减少了Ruminococcus的丰度，AFA增加了Prevotella的丰度，从而恢复血清代谢物水平。QAFA和AFA可能通过调节特定的肠道菌群来恢复胃肠激素水平和磷脂代谢，从而改善大鼠的FD症状。然而，它们在调节的具体菌群方面存在一些差异。

, authors=

黄文康，助理研究员，主要从事中药质量控制与新药研发，E-mail:

, authorsList=黄文康, 张其新, 刘晓彤, 田美子, 王海鸥, 陈佳卉, 高丽娟, 孙红祥, 屠珏, 汪丽霞, 叶益萍, authorCompany=null, correspAuthors=汪丽霞, 叶益萍, authorNote=null, correspAuthorsNote=

*

汪丽霞，高级农艺师，主要从事中药材技术研究，E-mail: ；

*

叶益萍，研究员，主要从事中药药效物质基础研究，E-mail:
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基于肠道菌群和代谢组学探讨衢枳壳治疗功能性消化不良大鼠的作用机制
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黄文康 1 , 张其新 1 , 刘晓彤 1 , 田美子 1 , 王海鸥 1 , 陈佳卉 1 , 高丽娟 1 , 孙红祥 2 , 屠珏 3, 4 , 汪丽霞 5, * , 叶益萍 1, *
中国中药杂志 | 药理 2026,51(2): 493-504
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中国中药杂志 |药理 2026 , 51 (2) : 493 -504
基于肠道菌群和代谢组学探讨衢枳壳治疗功能性消化不良大鼠的作用机制
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黄文康1 , 张其新1, 刘晓彤1, 田美子1, 王海鸥1, 陈佳卉1, 高丽娟1, 孙红祥2, 屠珏3, 4, 汪丽霞5, * , 叶益萍1, *
作者信息
  • 1．杭州医学院 药学院／食品科学与工程学院，浙江 杭州 310013
  • 2．浙江大学 动物科学学院，浙江 杭州 310058
  • 3．浙江中医药大学 中医药科学院，浙江 杭州 310053
  • 4．浙江中医药大学 比较医学研究所，浙江 杭州 310053
  • 5．常山县胡柚产业发展中心，浙江 衢州 324200
通讯作者:

*

汪丽霞，高级农艺师，主要从事中药材技术研究，E-mail: ；

*

叶益萍，研究员，主要从事中药药效物质基础研究，E-mail:
Mechanism of Quzhou Aurantii Fructus in treating rats with functional dyspepsia based on gut microbiota and metabolomics
Wen-kang HUANG1 , Qi-xin ZHANG1, Xiao-tong LIU1, Mei-zi TIAN1, Hai-ou WANG1, Jia-hui CHEN1, Li-juan GAO1, Hong-xiang SUN2, Jue TU3, 4, Li-xia WANG5, * , Yi-ping YE1, *
Affiliations
  • 1.School of Pharmacy/School of Food Science and Engineering, Hangzhou Medical College, Hangzhou 310013, China
  • 2.College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
  • 3.School of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • 4.Institute of Comparative Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • 5.Changshan Huyou Industry Development Center, Quzhou 324200, China
出版时间: 2026-01-15 doi: 10.19540/j.cnki.cjcmm.20250905.703
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评价和比较衢枳壳水提物（QAFA）和枳壳水提物（AFA）对功能性消化不良（FD）的治疗效果，并探讨其作用机制。以“夹尾+不规则饮食+稀酸水饮用”联合造模法构建FD大鼠模型。分别灌胃给予QAFA 2.05 g·kg-1（相当于衢枳壳4 g·kg-1）、AFA 1.93 g·kg-1（相当于枳壳4 g·kg-1），连续给药14 d后，测定胃排空率和小肠推进率；组织学分析胃窦和十二指肠组织的病理变化；ELISA法检测血清中胃泌素（GAS）和血管活性肠肽（VIP）的水平；利用16S rRNA测序和血清代谢组学探讨其潜在机制。结果显示，QAFA和AFA可增加胃肠动力；苏木精-伊红染色和免疫荧光分析显示，QAFA和AFA均可修复损伤的肠道屏障；ELISA结果显示均可调节血清中GAS和VIP水平，表明两者均可改善FD大鼠症状。肠道菌群分析显示，QAFA和AFA均降低了有害菌瘤胃球菌属Ruminococcus的丰度，而AFA同时增加了有益菌普雷沃菌属Prevotella和乳杆菌属Lactobacillus的丰度，QAFA则提高了Clostridia UCG-014的丰度。代谢组学分析显示，QAFA和AFA主要通过调节磷脂代谢来恢复血液中的代谢物水平。肠道菌群与代谢产物相关性分析显示QAFA和AFA均减少了Ruminococcus的丰度，AFA增加了Prevotella的丰度，从而恢复血清代谢物水平。QAFA和AFA可能通过调节特定的肠道菌群来恢复胃肠激素水平和磷脂代谢，从而改善大鼠的FD症状。然而，它们在调节的具体菌群方面存在一些差异。

功能性消化不良  /  衢枳壳  /  枳壳  /  肠道菌群  /  代谢组学

The therapeutic effects of Quzhou Aurantii Fructus aqueous extract (QAFA) and Aurantii Fructus aqueous extract (AFA) on functional dyspepsia (FD) in rats were evaluated and compared, and their underlying mechanisms were investigated. The FD rat models were constructed by a combined method of "pinching tail + irregular diet + drinking dilute acidic water". The rats were orally administered QAFA at a dose of 2.05 g·kg-1(equivalent to 4 g·kg-1 QAF) and AFA at a dose of 1.93 g·kg-1(equivalent to 4 g·kg-1 AF), respectively. After 14-day administration, the gastric emptying and intestinal propulsion were assessed. The pathological changes in the gastric antrum and duodenum were analyzed via histology, and the levels of serum gastrin (GAS) and vasoactive intestinal polypeptide (VIP) were measured by enzyme-linked immunosorbent assay. The underlying mechanisms were investigated by using 16S rRNA sequencing and serum metabolomics. The results showed that QAFA and AFA could increase gastrointestinal motility. Hematoxylin-eosin (HE) staining and immunofluorescence analysis showed that both QAFA and AFA repaired the damaged intestinal barrier, and ELISA analysis showed that they regulated GAS and VIP levels in serum. These results suggest that both can improve symptoms in FD rats. The intestinal microbiota analysis revealed that QAFA and AFA reduced the abundance of the harmful microbe Ruminococcus. AFA increased the abundance of the beneficial bacteria Prevotella and Lactobacillus, and QAFA increased the abundance of Clostridia UCG-014. Metabolomic analysis showed that both QAFA and AFA restored serum metabolites primarily through regulating phospholipid metabolism. Correlation analysis between metabolites and gut microbiota showed that both QAFA and AFA decreased the abundance of Ruminococcus, and AFA increased the abundance of Prevotella, thereby restoring serum metabolite levels. These findings suggest that QAFA and AFA may improve FD symptoms in rats by modulating specific gut microbiota to restore gastrointestinal hormones and phospholipid metabolism. However, there are some differences in the specific microbiotas they regulate.

functional dyspepsia  /  Quzhou Aurantii Fructus  /  Aurantii Fructus  /  gut microbiota  /  metabolomics
黄文康, 张其新, 刘晓彤, 田美子, 王海鸥, 陈佳卉, 高丽娟, 孙红祥, 屠珏, 汪丽霞, 叶益萍. 基于肠道菌群和代谢组学探讨衢枳壳治疗功能性消化不良大鼠的作用机制. 中国中药杂志, 2026 , 51 (2) : 493 -504 . DOI: 10.19540/j.cnki.cjcmm.20250905.703
Wen-kang HUANG, Qi-xin ZHANG, Xiao-tong LIU, Mei-zi TIAN, Hai-ou WANG, Jia-hui CHEN, Li-juan GAO, Hong-xiang SUN, Jue TU, Li-xia WANG, Yi-ping YE. Mechanism of Quzhou Aurantii Fructus in treating rats with functional dyspepsia based on gut microbiota and metabolomics[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (2) : 493 -504 . DOI: 10.19540/j.cnki.cjcmm.20250905.703
基金
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  • 浙江省自然科学基金项目(LZ24H280006)
  • 浙江省中医药科技项目(2021ZX004)
  • 衢州乡村振兴专家工作站项目
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2026年第51卷第2期
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doi: 10.19540/j.cnki.cjcmm.20250905.703
  • 接收时间：2025-07-22
  • 首发时间：2026-06-25
  • 出版时间：2026-01-15
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  • 收稿日期：2025-07-22
基金
浙江省自然科学基金项目(LZ24H280006)
浙江省中医药科技项目(2021ZX004)
衢州乡村振兴专家工作站项目
作者信息
    1．杭州医学院 药学院／食品科学与工程学院，浙江 杭州 310013
    2．浙江大学 动物科学学院，浙江 杭州 310058
    3．浙江中医药大学 中医药科学院，浙江 杭州 310053
    4．浙江中医药大学 比较医学研究所，浙江 杭州 310053
    5．常山县胡柚产业发展中心，浙江 衢州 324200

通讯作者:

*

汪丽霞，高级农艺师，主要从事中药材技术研究，E-mail: ；

*

叶益萍，研究员，主要从事中药药效物质基础研究，E-mail:
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https://castjournals.cast.org.cn/joweb/zgzyzz/CN/10.19540/j.cnki.cjcmm.20250905.703
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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