Article(id=1276976143777534325, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251113.201, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1754496000000, receivedDateStr=2025-08-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384437703, onlineDateStr=2026-06-25, pubDate=1768406400000, pubDateStr=2026-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384437703, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384437703, creator=13701087609, updateTime=1782384437703, updator=13701087609, issue=Issue{id=1276976057215488893, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='2', pageStart='301', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1768406400000', pubDateStr='2026-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782384417107, creator='13701087609', updateTime=1782384524478, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976507658563977, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976507658563978, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=456, endPage=471, ext={EN=ArticleExt(id=1276976143983055224, articleId=1276976143777534325, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Comparative study on composition and content of β-(1→3) -D-glucan in different medicinal parts of Poria cocos, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Poria cocos is a commonly used bulk traditional Chinese medicinal material, with multiple parts used medicinally, such as Poriae Cutis, Rubra Poria, White Poria, and Poria cum Radix Pini. Polysaccharides are their main active components. Clarifying the composition and content differences of polysaccharides in different medicinal parts of P. cocos can provide a reference for processing and clinical application of P. cocos medicinal materials and decoction pieces. In this paper, high-performance gel permeation chromatography (HPGPC) and nuclear magnetic resonance (NMR) spectroscopy were employed to qualitatively compare the relative molecular mass distribution and chemical composition of alkali-soluble polysaccharides from different parts of crude P. cocos. The results showed that the composition of alkali-soluble polysaccharides in Rubra Poria and Poriae Cutis was consistent with that in White Poria, all of which were β-(1→3) -D-glucans. The relative molecular mass distribution was also relatively close, ranging approximately from 9.13×10⁴ to 1.04×10⁵. On the basis of the content determination method of β-(1→3) -D-glucan in P. cocos according to the 2025 edition of Chinese Pharmacopoeia, the preparation method of the test sample solution was optimized. Firstly, a desalination step was added, which can enable the test sample chromatogram to present only the chromatographic peak of glucose, thereby reducing the difficulty of separation. Secondly, this experiment discovered for the first time that under acidic conditions, the hydrolysis of β-(1→3) -D-glucan to glucose was accompanied by the generation of a small amount of 5-hydroxymethylfurfural (5-HMF) as a by-product. A more intense acid hydrolysis reaction condition indicated a greater conversion yield of 5-HMF. Therefore, according to the results of single-factor experiments and response surface methodology experiments, the acid hydrolysis time was shortened from 6 h to 1.5 h, which improved the analysis efficiency. After verification, the optimized method was simple and stable, and had good repeatability and accuracy. Then, the optimized quantitative method was used to evaluate the content of β-(1→3) -D-glucan in different parts of crude P. cocos and decoction pieces. The results demonstrated that the content of β-(1→3) -D-glucan in different medicinal parts of P. cocos was in the order of White Poria, Poria cum Radix Pini, Rubra Poria, and Poriae Cutis. Among the commercially available Poria decoction pieces, the content of β-(1→3) -D-glucan in the white and hard decoction pieces was higher than that in the dark and loose-textured decoction pieces.

, authors=null, authorsList=Chen-xi YANG, Wei-wei WANG, Wei-hong FENG, Xiao-qian LIU, Yong-xin ZHANG, Hui-jing MAO, Zhi-min WANG, Li-hua YAN, authorCompany=null, correspAuthors=Zhi-min WANG, Li-hua YAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976144356348282, articleId=1276976143777534325, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=茯苓不同药用部位中β-（1→3）-D-葡聚糖的组成及含量比较研究, columnId=1276976014295167305, journalTitle=中国中药杂志, columnName=化学, runingTitle=null, highlight=null, articleAbstract=

茯苓是我国大宗常用中药材，多个部位可入药，常见的有茯苓皮、赤茯苓、白茯苓、茯神等，多糖是其主要药效物质。明确茯苓不同药用部位中多糖的组成和含量差异，可为茯苓类药材及饮片的产地加工及临床用药提供参考依据。该研究采用高效凝胶渗透色谱（HPGPC）、核磁共振光谱（NMR）等对茯苓菌核不同部位碱溶性多糖的相对分子质量分布、化学组成进行定性比较。结果表明，赤茯苓及茯苓皮中碱溶性多糖的组成与白茯苓中完全一致，均为β-（1→3）-D-葡聚糖，相对分子质量分布范围较接近，在9.13×10⁴～1.04×10⁵。基于2025年版《中国药典》茯苓中β-（1→3）-D-葡聚糖的含量测定法，对其供试品溶液的制备方法进行优化。首先，增加了除盐步骤，可使供试品色谱图中仅呈现待测物葡萄糖的色谱峰，降低了分离难度。其次，该试验首次发现，酸性条件下，茯苓β-（1→3）-D-葡聚糖水解为葡萄糖的过程中，同时伴随着少量5-羟甲基糠醛副产物的生成。酸水解反应条件越剧烈，5-羟甲基糠醛的生成量越大，因此，结合单因素试验和响应面试验考察结果，将酸水解时间由6 h缩短为1.5 h，提升了分析效率。经验证，优化后的方法简便、稳定且重复性、准确性良好。采用优化后的含量测定方法评价了茯苓菌核不同部位及茯苓类饮片中β-（1→3）-D-葡聚糖含量。结果表明，茯苓不同部位药材中β-（1→3）-D-葡聚糖的含量大小依次为白茯苓、茯神、赤茯苓、茯苓皮。市售茯苓饮片中，色白、质坚的饮片中β-（1→3）-D-葡聚糖含量高于色深、质地松泡的饮片。

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杨晨曦，硕士研究生，E-mail: yangcx915@163.com

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杨晨曦，硕士研究生，E-mail: yangcx915@163.com

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