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Article(id=1276976136374580156, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251021.301, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753632000000, receivedDateStr=2025-07-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384435980, onlineDateStr=2026-06-25, pubDate=1768406400000, pubDateStr=2026-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384435980, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384435980, creator=13701087609, updateTime=1782384435980, updator=13701087609, issue=Issue{id=1276976057215488893, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='2', pageStart='301', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1768406400000', pubDateStr='2026-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782384417107, creator='13701087609', updateTime=1782384524478, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976507658563977, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976507658563978, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=400, endPage=412, ext={EN=ArticleExt(id=1276976137104389054, articleId=1276976136374580156, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Research progress on stabilization mechanism of TCM volatile oil, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

TCM volatile oil exhibits excellent biological activities and wide application scenarios. However, its volatility and susceptibility to oxidation and deterioration severely restrict the quality of its preparations and clinical efficacy. Therefore, stabilizing TCM volatile oil is extremely necessary. Current research mainly focuses on the development of stabilization techniques and carrier materials, aiming to enhance its stability and endow it with sustained-release and controlled-release properties. In recent years, researchers have increasingly paid attention to the intrinsic mechanisms and potential interactions during the stabilization process, which is of great significance for the development of new stabilization technologies for volatile oil and the research on new dosage forms containing volatile oil. This article systematically reviews the mechanisms of action during the stabilization of TCM volatile oil and summarizes the key methods for characterizing interactions, with the aim of providing references for the development of new stabilization technologies for TCM volatile oil and the theoretical research on its stabilization.

, authors=null, authorsList=Qi-lin GUAN, Liang-shan MING, Zhi-jian ZHONG, Pan DENG, Ke PENG, Yong-mei GUAN, Wen-ting WU, Zhe LI, Wei-feng ZHU, authorCompany=null, correspAuthors=Zhe LI, Wei-feng ZHU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976138308154304, articleId=1276976136374580156, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=中药挥发油稳定化机制研究进展, columnId=1276975957151977760, journalTitle=中国中药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

中药挥发油具有良好的生物学活性和广泛的应用场景，但因其易挥发、氧化、变质，严重制约了其制剂产品的质量及临床药效。因此，对中药挥发油进行稳定化极为必要。当前研究主要集中在稳定化技术及载体材料的开发，旨在增强其稳定性并赋予缓释和控释特性。近年来，研究者们愈发关注稳定化过程中的内在机制及其潜在的相互作用，这对开发挥发油稳定新技术及含挥发油新剂型研究具有指导意义。该文系统综述了中药挥发油稳定化过程中的作用机制，并总结了关键的相互作用表征方法，以期为新型中药挥发油稳定化技术的开发及其理论基础研究提供参考。

, authors=

管祺临，硕士研究生，E-mail:

, authorsList=管祺临, 明良山, 钟志坚, 邓攀, 彭科, 管咏梅, 吴文婷, 李哲, 朱卫丰, authorCompany=null, correspAuthors=李哲, 朱卫丰, authorNote=null, correspAuthorsNote=

*

李哲，副教授，E-mail: ；

*

朱卫丰，教授，E-mail:
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管祺临，硕士研究生，E-mail:

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管祺临，硕士研究生，E-mail:

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中药挥发油稳定化机制研究进展
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管祺临 1, 4 , 明良山 1, 2 , 钟志坚 1, 3 , 邓攀 1, 3 , 彭科 1, 3 , 管咏梅 1 , 吴文婷 1 , 李哲 1, 4, * , 朱卫丰 1, *
中国中药杂志 | 综述 2026,51(2): 400-412
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中国中药杂志 |综述 2026 , 51 (2) : 400 -412
中药挥发油稳定化机制研究进展
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管祺临1, 4 , 明良山1, 2, 钟志坚1, 3, 邓攀1, 3, 彭科1, 3, 管咏梅1, 吴文婷1, 李哲1, 4, * , 朱卫丰1, *
作者信息
  • 1．江西中医药大学 现代中药制剂教育部重点实验室，江西 南昌 330004
  • 2．江西中医药大学 高等研究院，江西 南昌 330004
  • 3．江中药业股份有限公司，江西 南昌 330096
  • 4．中药改良创新江西省重点实验室，江西 南昌 330004
通讯作者:

*

李哲，副教授，E-mail: ；

*

朱卫丰，教授，E-mail:
Research progress on stabilization mechanism of TCM volatile oil
Qi-lin GUAN1, 4 , Liang-shan MING1, 2, Zhi-jian ZHONG1, 3, Pan DENG1, 3, Ke PENG1, 3, Yong-mei GUAN1, Wen-ting WU1, Zhe LI1, 4, * , Wei-feng ZHU1, *
Affiliations
  • 1.Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2.Advanced Research Institute, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 3.Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330096, China
  • 4.Jiangxi Provincial Key Laboratory of Chinese Medicine Improvement and Innovation, Nanchang 330004, China
出版时间: 2026-01-15 doi: 10.19540/j.cnki.cjcmm.20251021.301
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中药挥发油具有良好的生物学活性和广泛的应用场景，但因其易挥发、氧化、变质，严重制约了其制剂产品的质量及临床药效。因此，对中药挥发油进行稳定化极为必要。当前研究主要集中在稳定化技术及载体材料的开发，旨在增强其稳定性并赋予缓释和控释特性。近年来，研究者们愈发关注稳定化过程中的内在机制及其潜在的相互作用，这对开发挥发油稳定新技术及含挥发油新剂型研究具有指导意义。该文系统综述了中药挥发油稳定化过程中的作用机制，并总结了关键的相互作用表征方法，以期为新型中药挥发油稳定化技术的开发及其理论基础研究提供参考。

中药挥发油  /  稳定化  /  氢键  /  范德华力  /  化学键  /  疏水作用

TCM volatile oil exhibits excellent biological activities and wide application scenarios. However, its volatility and susceptibility to oxidation and deterioration severely restrict the quality of its preparations and clinical efficacy. Therefore, stabilizing TCM volatile oil is extremely necessary. Current research mainly focuses on the development of stabilization techniques and carrier materials, aiming to enhance its stability and endow it with sustained-release and controlled-release properties. In recent years, researchers have increasingly paid attention to the intrinsic mechanisms and potential interactions during the stabilization process, which is of great significance for the development of new stabilization technologies for volatile oil and the research on new dosage forms containing volatile oil. This article systematically reviews the mechanisms of action during the stabilization of TCM volatile oil and summarizes the key methods for characterizing interactions, with the aim of providing references for the development of new stabilization technologies for TCM volatile oil and the theoretical research on its stabilization.

TCM volatile oil  /  stabilization  /  hydrogen bond  /  van der Waals force  /  chemical bond  /  hydrophobic interaction
管祺临, 明良山, 钟志坚, 邓攀, 彭科, 管咏梅, 吴文婷, 李哲, 朱卫丰. 中药挥发油稳定化机制研究进展. 中国中药杂志, 2026 , 51 (2) : 400 -412 . DOI: 10.19540/j.cnki.cjcmm.20251021.301
Qi-lin GUAN, Liang-shan MING, Zhi-jian ZHONG, Pan DENG, Ke PENG, Yong-mei GUAN, Wen-ting WU, Zhe LI, Wei-feng ZHU. Research progress on stabilization mechanism of TCM volatile oil[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (2) : 400 -412 . DOI: 10.19540/j.cnki.cjcmm.20251021.301
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  • 国家自然科学基金项目(82204630)
  • 赣鄱俊才支持计划·青年科技托举人才项目(2025QT07)
  • 江西省重点研发计划项目(S2024ZPYFG0003)
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doi: 10.19540/j.cnki.cjcmm.20251021.301
  • 接收时间：2025-07-28
  • 首发时间：2026-06-25
  • 出版时间：2026-01-15
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  • 收稿日期：2025-07-28
基金
国家自然科学基金项目(82204630)
赣鄱俊才支持计划·青年科技托举人才项目(2025QT07)
江西省重点研发计划项目(S2024ZPYFG0003)
作者信息
    1．江西中医药大学 现代中药制剂教育部重点实验室，江西 南昌 330004
    2．江西中医药大学 高等研究院，江西 南昌 330004
    3．江中药业股份有限公司，江西 南昌 330096
    4．中药改良创新江西省重点实验室，江西 南昌 330004

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李哲，副教授，E-mail: ；

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朱卫丰，教授，E-mail:
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https://castjournals.cast.org.cn/joweb/zgzyzz/CN/10.19540/j.cnki.cjcmm.20251021.301
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Number of
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Number of
species		 占总种数比例
Percentage of
total species (%)		 属
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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