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Article(id=1276976119991636216, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251011.705, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756224000000, receivedDateStr=2025-08-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384432075, onlineDateStr=2026-06-25, pubDate=1768406400000, pubDateStr=2026-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384432075, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384432075, creator=13701087609, updateTime=1782384432075, updator=13701087609, issue=Issue{id=1276976057215488893, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='2', pageStart='301', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1768406400000', pubDateStr='2026-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782384417107, creator='13701087609', updateTime=1782384524478, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976507658563977, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976507658563978, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=524, endPage=532, ext={EN=ArticleExt(id=1276976120364929274, articleId=1276976119991636216, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Molecular mechanism of Panlongqi Tablets in ameliorating rheumatoid arthritis by suppressing PI3K-AKT-GSK-3β signaling pathway-mediated inflammatory responses, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Based on the holistic regulation and multi-target characteristics of TCM, this study investigated the mechanism of Panlongqi Tablets (PLQT) in ameliorating rheumatoid arthritis (RA) by regulating key proteins, including glycogen synthase kinase-3β (GSK-3β), phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA), and protein kinase B3 (AKT3), within the PI3K-AKT signaling pathway. An adjuvant-induced arthritis (AIA) rat model was established by intradermal injection of type Ⅱ collagen-Freund's complete adjuvant into the right hind paw, and rats received different doses of PLQT for intervention. Pharmacodynamic effects were evaluated by monitoring changes in body weight, measuring paw swelling, observing ankle synovial tissue pathology via hematoxylin-eosin (HE) staining, and detecting serum levels of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), using ELISA. Targets identified through prior network pharmacology screening were integrated with therapy-related biomarkers from untargeted metabolomics for key pathway enrichment and identification of critical targets. Western blot and RT-qPCR were subsequently used to validate the expression of these key targets. Animal experimental results showed that, compared with the model group, all PLQT dose groups significantly improved weight loss, reduced paw swelling, inhibited synovial tissue fibrosis hyperplasia and inflammatory cell infiltration, and decreased serum levels of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β in RA rats, exhibiting a partial dose-dependent manner. Metabolomics analysis revealed that PLQT exerted regulatory effects on 179 of 276 RA-related biomarkers. Enrichment analysis revealed that GSK-3β, PIK3CA, and AKT3 proteins in the PI3K-AKT signaling pathway were the key targets for PLQT intervention in RA. Validation by Western blot and RT-qPCR demonstrated that PLQT significantly modulated the expression of these three proteins. In conclusion, the therapeutic effects of PLQT on RA are likely associated with regulation of GSK-3β, PIK3CA, and AKT3 within the PI3K-AKT signaling pathway.

, authors=null, authorsList=Rong MA, Yan-ting ZHAO, Yan LIU, Yan-ru LIU, Zhi-shu TANG, Zhong-xing SONG, Rui ZHOU, De-zhu ZHANG, Li ZHANG, authorCompany=null, correspAuthors=Yan-ru LIU, Zhi-shu TANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976120947937532, articleId=1276976119991636216, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=盘龙七片通过抑制PI3K-AKT-GSK-3β信号通路介导的炎症反应改善类风湿性关节炎的分子机制研究, columnId=1276975994707775974, journalTitle=中国中药杂志, columnName=药理, runingTitle=null, highlight=null, articleAbstract=

该研究基于中药整体调节与多靶点作用特点，探讨盘龙七片通过调控磷脂酰肌醇3-激酶（PI3K）-蛋白激酶B （AKT）信号通路关键蛋白糖原合成酶激酶-3β（GSK-3β）、磷脂酰肌醇3-激酶催化亚基α（PIK3CA）、蛋白激酶B3（AKT3）改善类风湿性关节炎的作用机制。采用右后足掌皮内注射Ⅱ型胶原蛋白-完全弗氏佐剂诱导佐剂性关节炎大鼠模型，给予不同剂量盘龙七片进行干预，通过观察大鼠体质量变化，测量足趾容积，HE染色观察踝关节滑膜组织病理形态及ELISA检测血清炎症因子肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）水平评估药效；将前期网络药理学筛选得到的靶点与非靶向代谢组学得到的与治疗相关的生物标记物进行关联，用于关键通路富集以及关键靶点获取，然后利用Western blot和RT-qPCR方法对关键靶点进行验证。动物实验结果显示，与模型组比较，盘龙七片各剂量组均能显著改善类风湿性关节炎（RA）大鼠的体质量下降趋势，减轻足趾肿胀程度，抑制滑膜组织纤维增生和炎性细胞浸润，并降低血清中TNF-α、IL-6、IL-1β等促炎因子水平，且呈现一定的剂量依赖性。代谢组学结果显示，盘龙七片对RA相关的276个生物标记物中的179个有调控作用。富集结果显示，PI3K-AKT信号通路中的GSK-3β、PIK3CA和AKT3蛋白是盘龙七片干预RA的关键靶点。Western blot和RT-qPCR对关键靶点的验证结果显示，盘龙七片对以上3个靶点有显著调控作用。综上所述，盘龙七片对类风湿性关节炎的干预作用可能与其对PI3K-AKT信号通路的GSK-3β、PIK3CA和AKT3蛋白的调控有关。

, authors=

马荣，硕士研究生，E-mail:

, authorsList=马荣, 赵艳婷, 刘妍, 刘妍如, 唐志书, 宋忠兴, 周瑞, 张德柱, 张丽, authorCompany=null, correspAuthors=刘妍如, 唐志书, authorNote=null, correspAuthorsNote=

*

刘妍如，教授，硕士生导师，主要从事中药质量控制及物质基础研究，E-mail: ；

*

唐志书，教授，博士生导师，主要从事中药资源开发与中药质量分析研究，E-mail:
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盘龙七片通过抑制PI3K-AKT-GSK-3β信号通路介导的炎症反应改善类风湿性关节炎的分子机制研究
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马荣 1 , 赵艳婷 1 , 刘妍 1 , 刘妍如 1, * , 唐志书 1, 2, * , 宋忠兴 1 , 周瑞 1 , 张德柱 3 , 张丽 4
中国中药杂志 | 药理 2026,51(2): 524-532
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中国中药杂志 |药理 2026 , 51 (2) : 524 -532
盘龙七片通过抑制PI3K-AKT-GSK-3β信号通路介导的炎症反应改善类风湿性关节炎的分子机制研究
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马荣1 , 赵艳婷1, 刘妍1, 刘妍如1, * , 唐志书1, 2, * , 宋忠兴1, 周瑞1, 张德柱3, 张丽4
作者信息
  • 1．陕西中医药大学 陕西中药资源产业化省部共建协同创新中心，陕西 咸阳 712083
  • 2．北京中医药大学，北京 100700
  • 3．陕西盘龙药业集团股份有限公司，陕西 商洛 711400
  • 4．陕西中医药大学附属医院，陕西 咸阳 712000
通讯作者:

*

刘妍如，教授，硕士生导师，主要从事中药质量控制及物质基础研究，E-mail: ；

*

唐志书，教授，博士生导师，主要从事中药资源开发与中药质量分析研究，E-mail:
Molecular mechanism of Panlongqi Tablets in ameliorating rheumatoid arthritis by suppressing PI3K-AKT-GSK-3β signaling pathway-mediated inflammatory responses
Rong MA1 , Yan-ting ZHAO1, Yan LIU1, Yan-ru LIU1, * , Zhi-shu TANG1, 2, * , Zhong-xing SONG1, Rui ZHOU1, De-zhu ZHANG3, Li ZHANG4
Affiliations
  • 1.Shaanxi Provincial and Ministerial Co-constructed Collaborative Innovation Center for Industrialization of Traditional Chinese Medicine Resources, Shaanxi University of Chinese Medicine, Xianyang 712083, China
  • 2.Beijing University of Chinese Medicine, Beijing 100700, China
  • 3.Shaanxi Panlong Pharmaceutical Group Co., Ltd., Shangluo 711400, China
  • 4.Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
出版时间: 2026-01-15 doi: 10.19540/j.cnki.cjcmm.20251011.705
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该研究基于中药整体调节与多靶点作用特点，探讨盘龙七片通过调控磷脂酰肌醇3-激酶（PI3K）-蛋白激酶B （AKT）信号通路关键蛋白糖原合成酶激酶-3β（GSK-3β）、磷脂酰肌醇3-激酶催化亚基α（PIK3CA）、蛋白激酶B3（AKT3）改善类风湿性关节炎的作用机制。采用右后足掌皮内注射Ⅱ型胶原蛋白-完全弗氏佐剂诱导佐剂性关节炎大鼠模型，给予不同剂量盘龙七片进行干预，通过观察大鼠体质量变化，测量足趾容积，HE染色观察踝关节滑膜组织病理形态及ELISA检测血清炎症因子肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）水平评估药效；将前期网络药理学筛选得到的靶点与非靶向代谢组学得到的与治疗相关的生物标记物进行关联，用于关键通路富集以及关键靶点获取，然后利用Western blot和RT-qPCR方法对关键靶点进行验证。动物实验结果显示，与模型组比较，盘龙七片各剂量组均能显著改善类风湿性关节炎（RA）大鼠的体质量下降趋势，减轻足趾肿胀程度，抑制滑膜组织纤维增生和炎性细胞浸润，并降低血清中TNF-α、IL-6、IL-1β等促炎因子水平，且呈现一定的剂量依赖性。代谢组学结果显示，盘龙七片对RA相关的276个生物标记物中的179个有调控作用。富集结果显示，PI3K-AKT信号通路中的GSK-3β、PIK3CA和AKT3蛋白是盘龙七片干预RA的关键靶点。Western blot和RT-qPCR对关键靶点的验证结果显示，盘龙七片对以上3个靶点有显著调控作用。综上所述，盘龙七片对类风湿性关节炎的干预作用可能与其对PI3K-AKT信号通路的GSK-3β、PIK3CA和AKT3蛋白的调控有关。

盘龙七片  /  类风湿性关节炎  /  PI3K-AKT信号通路  /  GSK-3β  /  PIK3CA  /  AKT3

Based on the holistic regulation and multi-target characteristics of TCM, this study investigated the mechanism of Panlongqi Tablets (PLQT) in ameliorating rheumatoid arthritis (RA) by regulating key proteins, including glycogen synthase kinase-3β (GSK-3β), phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA), and protein kinase B3 (AKT3), within the PI3K-AKT signaling pathway. An adjuvant-induced arthritis (AIA) rat model was established by intradermal injection of type Ⅱ collagen-Freund's complete adjuvant into the right hind paw, and rats received different doses of PLQT for intervention. Pharmacodynamic effects were evaluated by monitoring changes in body weight, measuring paw swelling, observing ankle synovial tissue pathology via hematoxylin-eosin (HE) staining, and detecting serum levels of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), using ELISA. Targets identified through prior network pharmacology screening were integrated with therapy-related biomarkers from untargeted metabolomics for key pathway enrichment and identification of critical targets. Western blot and RT-qPCR were subsequently used to validate the expression of these key targets. Animal experimental results showed that, compared with the model group, all PLQT dose groups significantly improved weight loss, reduced paw swelling, inhibited synovial tissue fibrosis hyperplasia and inflammatory cell infiltration, and decreased serum levels of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β in RA rats, exhibiting a partial dose-dependent manner. Metabolomics analysis revealed that PLQT exerted regulatory effects on 179 of 276 RA-related biomarkers. Enrichment analysis revealed that GSK-3β, PIK3CA, and AKT3 proteins in the PI3K-AKT signaling pathway were the key targets for PLQT intervention in RA. Validation by Western blot and RT-qPCR demonstrated that PLQT significantly modulated the expression of these three proteins. In conclusion, the therapeutic effects of PLQT on RA are likely associated with regulation of GSK-3β, PIK3CA, and AKT3 within the PI3K-AKT signaling pathway.

Panlongqi Tablets  /  rheumatoid arthritis  /  PI3K-AKT signaling pathway  /  GSK-3β  /  PIK3CA  /  AKT3
马荣, 赵艳婷, 刘妍, 刘妍如, 唐志书, 宋忠兴, 周瑞, 张德柱, 张丽. 盘龙七片通过抑制PI3K-AKT-GSK-3β信号通路介导的炎症反应改善类风湿性关节炎的分子机制研究. 中国中药杂志, 2026 , 51 (2) : 524 -532 . DOI: 10.19540/j.cnki.cjcmm.20251011.705
Rong MA, Yan-ting ZHAO, Yan LIU, Yan-ru LIU, Zhi-shu TANG, Zhong-xing SONG, Rui ZHOU, De-zhu ZHANG, Li ZHANG. Molecular mechanism of Panlongqi Tablets in ameliorating rheumatoid arthritis by suppressing PI3K-AKT-GSK-3β signaling pathway-mediated inflammatory responses[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (2) : 524 -532 . DOI: 10.19540/j.cnki.cjcmm.20251011.705
基金
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  • 陕西省中医药科技创新提质扩能计划项目(TZKN-CXRC-23)
  • 全国中药特色技术传承人才培训项目(国中医药人教函［2023］96号)
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doi: 10.19540/j.cnki.cjcmm.20251011.705
  • 接收时间：2025-08-27
  • 首发时间：2026-06-25
  • 出版时间：2026-01-15
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  • 收稿日期：2025-08-27
基金
陕西省中医药科技创新提质扩能计划项目(TZKN-CXRC-23)
全国中药特色技术传承人才培训项目(国中医药人教函［2023］96号)
作者信息
    1．陕西中医药大学 陕西中药资源产业化省部共建协同创新中心，陕西 咸阳 712083
    2．北京中医药大学，北京 100700
    3．陕西盘龙药业集团股份有限公司，陕西 商洛 711400
    4．陕西中医药大学附属医院，陕西 咸阳 712000

通讯作者:

*

刘妍如，教授，硕士生导师，主要从事中药质量控制及物质基础研究，E-mail: ；

*

唐志书，教授，博士生导师，主要从事中药资源开发与中药质量分析研究，E-mail:
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https://castjournals.cast.org.cn/joweb/zgzyzz/CN/10.19540/j.cnki.cjcmm.20251011.705
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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