Article(id=1276976067130815022, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251011.501, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1751385600000, receivedDateStr=2025-07-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384419472, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384419472, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384419471, creator=13701087609, updateTime=1782384419471, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=56, endPage=63, ext={EN=ArticleExt(id=1276976067533468208, articleId=1276976067130815022, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Application of combination of traditional Chinese medicine and western medicine in epilepsy prevention and treatment, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Epilepsy is a common neurological disorder characterized by refractoriness and recurrence. In China, the prevalence rate is 0.4%-0.7%, with currently over nine million patients, among whom approximately 30% suffer from refractory epilepsy. Although antiepileptic drugs (AEDs) are the mainstay of treatment, they are associated with multi-system adverse reactions and drug resistance issues. In contrast, traditional Chinese medicine (TCM) treatment exhibits significant efficacy with lower toxicity and side effects, and integrated TCM and western medicine treatment can achieve complementary advantages. Studies have shown that integrated therapy demonstrates benefits in various types of epilepsy, including status epilepticus, post-stroke epilepsy, post-traumatic epilepsy, pediatric epilepsy, refractory epilepsy, and epilepsy comorbid with depression and anxiety. It exerts synergistic effects by enhancing AED bioavailability (borneol improves blood-brain barrier permeability), reducing seizure frequency, preventing recurrence, and minimizing western medicine toxicity (Dingxian Decoction decreases digestive/neurological adverse reactions). The underlying mechanisms involve regulating neurotransmitters (modulating glutamate and γ-aminobutyric acid levels) and ion channels (inhibiting sodium/calcium ion channels). In terms of preventive care, TCM plays an important role in preventing epileptic seizures by correcting biased constitutional states. In the future, integrated TCM and western medicine in epilepsy prevention and treatment will move toward individualized treatment, etiological treatment, preventive rehabilitation, and integration of scientific research with clinical practice, forming a three-dimensional development pattern of "technology empowerment, standard guidance, and whole-process management".

, authors=null, authorsList=Yuan YAO, Xue-pin WANG, Rui-fan LIN, Wen-ya GAO, Hong-wei ZHOU, Qi XIE, authorCompany=null, correspAuthors=Wen-ya GAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976067973870130, articleId=1276976067130815022, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=中西医结合防治癫痫的应用, columnId=1276975957151977760, journalTitle=中国中药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

癫痫是一种难治和反复发作的常见神经科疾病，我国患病率为0.4%～0.7%，约有900万例以上的患者，其中30%为难治性癫痫。西医抗癫痫药物虽是主要治疗手段，但存在多系统不良反应及耐药问题，而中医药治疗疗效显著且不良反应较低，中西医结合可实现优势互补。研究表明，中西医结合在癫痫持续状态、卒中后癫痫、脑外伤后癫痫、儿童癫痫、难治性癫痫及癫痫共病抑郁焦虑等治疗中均显示优势，可通过提高抗癫痫药物利用率（如冰片改善血脑屏障渗透率）、降低发作频率、预防复发及减少西药不良反应（如定痫汤降低消化／神经系统不良反应）等发挥协同作用；其机制涉及调控神经递质（如调节谷氨酸、γ-氨基丁酸水平）及离子通道（如抑制钠／钙离子通道）。在预防调护方面，中医药通过纠正偏颇体质状态，对预防癫痫发作具有重要意义。未来，中西医结合在癫痫防治领域将朝着个体化治疗、病因治疗、预防康复及科学研究与临床实践相结合的方向发展，形成“技术赋能、标准引领、全程管理”的立体化发展格局。

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姚渊，助理研究员，主要从事中医病证规律与通治方研究，E-mail: 1941627107@qq.com

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姚渊，助理研究员，主要从事中医病证规律与通治方研究，E-mail: 1941627107@qq.com

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