Article(id=1276976015511523950, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20250916.301, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1746460800000, receivedDateStr=2025-05-06, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384407165, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384407165, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384407165, creator=13701087609, updateTime=1782384407165, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=92, endPage=102, ext={EN=ArticleExt(id=1276976015704461936, articleId=1276976015511523950, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Hepatotoxicity and renotoxicity of different processed products of Strychnos nux-vomica seeds based on serum metabolomics and their mechanisms of action, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

This study investigated the toxicological mechanisms of different processed products of Strychnos nux-vomica seeds using serum metabolomics analysis. Seventy-two female KM mice were randomly divided into six groups (n = 12 per group): control, raw seeds, vinegar-processed seeds, urine-soaked seeds, sand-roasted seeds, and oil-fried seeds. Each processed preparation group received an aqueous decoction of the original herb at the same concentration for 7 days. Hepatic and renal coefficients were measured in each group, and the levels of hepatic and renal injury markers, including aspartate transaminase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), and creatinine (CRE) were determined using a fully automated biochemical analyzer. Hematoxylin-eosin (HE) staining was used for histopathological examination of the liver and kidney. Liquid chromatography-mass spectrometry (LC-MS/MS) combined with multivariate statistical analysis was employed to screen for differential serum metabolites across groups. Metabolic pathway enrichment analysis of the selected differential markers was performed using the Human Metabolome Database (HMDB) and MetaboAnalyst 6.0. All processed S. nux-vomica seed products increased hepatic and renal coefficients and elevated hepatic and renal injury markers (AST, ALT, BUN, CRE), although these effects were reduced to varying degrees compared to the raw product. Overall, vinegar processing exhibited the most significant detoxification effect, followed by oil-fried>sand-roasted≈urine-soaked > raw seeds. Metabolomic analysis identified 14 differential metabolites across the groups, primarily including sphingolipids, glycerophospholipids, and vitamin-related compounds. Five significantly perturbed metabolic pathways were identified: sphingolipid metabolism, glycerophospholipid metabolism, α-linolenic acid metabolism, lipoic acid metabolism, and linoleic acid metabolism, with sphingolipid and glycerophospholipid metabolism common to all groups. In conclusion, processing of S. nux-vomica seeds reduced hepatorenal toxicity to varying degrees, and its toxic mechanisms may primarily involve disturbances in sphingolipid and glycerophospholipid metabolism.

, authors=null, authorsList=Hai-lian ZHENG, Na ZHANG, Xian ZHANG, Cheng XU, Ling-bang MENG, Mei-qi LU, Yi-lin LI, Qi-yue SHI, Huan YU, authorCompany=null, correspAuthors=Huan YU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976016300053106, articleId=1276976015511523950, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=基于血清代谢组学比较马钱子不同炮制品肝肾毒性及作用机制研究, columnId=1276975978656174488, journalTitle=中国中药杂志, columnName=制剂与炮制, runingTitle=null, highlight=null, articleAbstract=

该研究基于血清代谢组学比较马钱子不同炮制品毒性，对其毒性机制进行探究。将72只雌性KM小鼠随机分为6组，分别为空白组、生品马钱子组、醋制马钱子组、尿泡马钱子组、砂烫马钱子组、油炸马钱子组，每组12只，各炮制品组给予相同浓度原药材水煎液7 d，考察各组肝肾系数，运用全自动生化分析仪测定肝肾损伤指标谷草转氨酶（AST）、谷丙转氨酶（ALT）、尿素氮（BUN）和肌酐（CRE）的表达水平；使用苏木素-伊红（HE）染色法对肝肾进行组织病理学检查；利用液相色谱-质谱（LC-MS/MS）技术结合多元统计分析筛选各组血清差异代谢物，基于人类代谢组数据库（HMDB）数据库结合MetaboAnalyst 6.0对筛选出的差异标志物进行代谢通路富集分析。马钱子不同炮制品均能使小鼠肝肾系数上升，并使肝肾损伤指标AST、ALT和BUN、CRE表达水平上升，但各炮制品相比生品均有不同程度降低，综合来看醋制品的减毒效果更好，其次是油炸组>砂烫组≈尿泡组>生品组；各组小鼠血清通过代谢组学分析共鉴定出14种差异代谢物，主要为鞘脂类、甘油磷脂类、维生素类等化合物，筛选出具有显著性影响的代谢通路共5条，包括鞘脂代谢、甘油磷脂代谢、α-亚麻酸代谢、硫辛酸代谢和亚油酸代谢，其中鞘脂代谢和甘油磷脂代谢为各组共有代谢通路。综上所述，马钱子经过炮制后对肝肾损伤程度均有不同程度的降低，其毒性机制可能主要与鞘脂代谢和甘油磷脂代谢紊乱有关。

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郑海连，硕士研究生，主要从事中药饮片标准化与炮制机制研究，E-mail: 3331908809@qq.com

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郑海连，硕士研究生，主要从事中药饮片标准化与炮制机制研究，E-mail: 3331908809@qq.com

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