Article(id=1276976013011710278, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251104.201, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750435200000, receivedDateStr=2025-06-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384406569, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384406569, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384406569, creator=13701087609, updateTime=1782384406569, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=103, endPage=113, ext={EN=ArticleExt(id=1276976014173532488, articleId=1276976013011710278, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Chemical constituents from stem bark of Aquilaria yunnanensis and their anti-inflammatory activities, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

The stem bark of Aquilaria yunnanensis (Thymelaeaceae) is traditionally used to treat cough and asthma in folk medicine. However, its active components have not been reported. In the present study, the chemical constituents of A. yunnanensis stem bark were isolated and identified, and their inhibitory activities against nitric oxide (NO) production in RAW264.7 cells induced by lipopolysaccharide (LPS) were evaluated to clarify the anti-inflammatory components in the stem bark of A. yunnanensis. A total of 22 compounds, including a new norlignan [(±)-1], were isolated from the ethanolic extract of A. yunnanensis stem bark by column chromatography, high-performance liquid chromatography (HPLC), recrystallization, etc. Through chiral separation of (±)-1, (-)-1 and (+)-1 were obtained. Based on electronic circular dichroism (ECD) calculations, the absolute configurations of (-)-1 and (+)-1 were determined to be (-)-(7R, 8S, 8′S)-4-O- (1, 3-dihydroxypropan-2-yl) zhebeiresinol and (+)-(7S, 8R, 8′R)-4-O- (1, 3-dihydroxypropan-2-yl) zhebeiresinol. The known compounds included (±)-zhebeiresinol (2), (+)-syringaresinol (3), (+)-episyringaresinol (4), orcinol (5), orsellinic acid (6), methyl orsellinate (7), 3, 4-dihydroxybenzoic acid (8), lecanoric acid (9), barbatic acid (10), 7β-hydroxy-β-sitosterol (11), β-sitosterol (12), stigmasterol (13), ergosterol peroxide (14), genkwanin (15), pilloin (16), 5-hydroxy-3′, 4′, 7-trimethoxyflavone (17), (-)-epicatechin (18), (-)-epicatechin gallate (19), tectorigenin 2-O-α-L-rhamnopyranoside (20), 2, 3-dihydroxypropyl docosanoate (21), and 1-O-linolenoylglycerol (22). According to the bioassay testing results, compounds 4 and 22 which inhibited NO production with IC₅₀ values of (32.82±1.04) and (18.50±0.95) μmol·L^-1, respectively, exhibited anti-inflammatory activities.

, authors=null, authorsList=Li-lin ZHENG, Dong-bao HU, Jun YANG, Ya-jun HAN, Qing-hua KONG, Xiao-yan DUAN, Ji-feng LUO, Yun-song WANG, Jing-hua YANG, Yue-hu WANG, authorCompany=null, correspAuthors=Jing-hua YANG, Yue-hu WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976015419240780, articleId=1276976013011710278, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=云南沉香茎皮化学成分及其抗炎活性研究, columnId=1276976014295167305, journalTitle=中国中药杂志, columnName=化学, runingTitle=null, highlight=null, articleAbstract=

瑞香科植物云南沉香Aquilaria yunnanensis的茎皮在民间用于治疗咳喘，但其活性成分未见报道。该研究对云南沉香茎皮的化学成分进行分离和鉴定，并评价其对脂多糖（LPS）诱导的RAW264.7细胞中一氧化氮（NO）生成的抑制活性，旨在阐明云南沉香茎皮中的抗炎活性成分。通过柱色谱、高效液相色谱和重结晶等方法，从云南沉香茎皮乙醇提取物中分离得到22个化合物，包括1个新的降木脂素［（±）-1］，经过对（±）-1进行手性拆分，得到（-）-1和（+）-1，采用电子圆二色谱（ECD）计算，确定了（-）-1和（+）-1的绝对构型分别是（-）-（7R，8S，8′S）-4-O-（1，3-二羟基丙-2-基）浙贝素和（+）-（7S，8R，8′R）-4-O-（1，3-二羟基丙-2-基）浙贝素；已知化合物包括（±）-浙贝素（2）、（+）-丁香树脂酚（3）、（+）-表丁香脂素（4）、苔黑酚（5）、苔色酸（6）、苔色酸甲酯（7）、3，4-二羟基苯甲酸（8）、茶渍酸（9）、巴巴酸（10）、7β-羟基-β-谷甾醇（11）、β-谷甾醇（12）、豆甾醇（13）、过氧化麦角甾醇（14）、芫花素（15）、pilloin（16）、5-羟基-3′，4′，7-三甲氧基黄酮（17）、（-）-表儿茶素（18）、（-）-表儿茶素没食子酸酯（19）、鸢尾酚酮-2-O-α-L-吡喃鼠李糖苷（20）、2，3-二羟基丙基二十二酸酯（21）、1-O-亚麻酰基甘油（22）。活性测试结果显示，化合物4和22对NO生成抑制的IC₅₀分别为（32.82±1.04）、（18.50±0.95）μmol·L^-1，具有一定的抗炎活性。

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