Article(id=1276976005302584254, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251212.412, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1764000000000, receivedDateStr=2025-11-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384404730, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384404730, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384404730, creator=13701087609, updateTime=1782384404730, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1, endPage=9, ext={EN=ArticleExt(id=1276976005722014656, articleId=1276976005302584254, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Molecular Pharmacognosy revisited: charting a new course after three decades, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Since its conceptual inception in 1995, Molecular Pharmacognosy has evolved over three decades from a nascent idea into a frontier interdisciplinary discipline characterized by a comprehensive theoretical system, mature methodologies, and extensive applications. This paper systematically reviews the significant milestones of this discipline in theoretical innovation, technical standardization, industrial application, and platform construction. It highlights breakthrough achievements in areas such as technical standards for the molecular identification of crude drugs, elucidation of the formation mechanisms of Dao-di herbs, establishment of conservation models for rare and endangered resources, and biosynthesis of active compounds. The paper further elucidates the evolutionary research paradigm of Molecular Pharmacognosy. Originating from phenomena observed in both the discipline and the industry, this paradigm advances through a progressive cycle of problem derivation—hypothesis presupposition—technical innovation—theoretical enrichment, driven by the dynamic interplay between theory and practice. Furthermore, the paper analyzes current challenges regarding the precision of molecular identification, the complex mechanisms of geo-authenticity, and the sustainable utilization of resources. Molecular Pharmacognosy is poised to integrate deeply with frontier technologies such as artificial intelligence, pan-omics, quantum computing, biomanufacturing, smart breeding, and gene editing. This integration will drive a revolutionary shift in the research paradigm from recognition and revelation to prediction and design. Ultimately, these achievements will mark a new phase defined by precision, systematization, and engineering, injecting fresh momentum into the modernization of TCM.

, authors=null, authorsList=Lu-qi HUANG, Han ZHENG, Yuan YUAN, Juan GUO, authorCompany=null, correspAuthors=Lu-qi HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976006166610883, articleId=1276976005302584254, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=再论分子生药学——三十年,一个新起点, columnId=1276976005801706433, journalTitle=中国中药杂志, columnName=专论, runingTitle=null, highlight=null, articleAbstract=

分子生药学自1995年概念提出至今三十年来,已从概念萌芽成长为一门理论体系完善、技术方法成熟、应用范围广泛的前沿交叉学科。该文系统回顾了该学科在理论创新、技术标准、产业应用及平台建设等方面的重要进展,包括生药分子鉴定技术标准、道地药材形成机制解析、珍稀资源保护模式建立、活性成分生物合成等领域的突破性成果;阐述了分子生药学从学科和产业存在的现象为起点,通过“问题衍生—假说预设—技术创新—理论丰富”的递进过程,形成了一个在理论与实践相互作用下不断演进的学科研究范式;分析了当前在分子鉴定精度、道地性形成机制、资源可持续利用等方面仍面临的挑战。展望未来,分子生药学将与人工智能、全景组学、量子计算、生物制造、智能育种与基因编辑等前沿技术深度融合,推动研究范式从“认识与揭示”向“预测与设计”的革命性转变,迈向精准化、系统化与工程化的新起点,为中医药现代化注入全新动力。

, authors=null, authorsList=黄璐琦, 郑汉, 袁媛, 郭娟, authorCompany=null, correspAuthors=黄璐琦, authorNote=null, correspAuthorsNote=

*

黄璐琦,E-mail:
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再论分子生药学——三十年,一个新起点
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黄璐琦 * , 郑汉 , 袁媛 , 郭娟
中国中药杂志 | 专论 2026,51(1): 1-9
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中国中药杂志 |专论 2026 , 51 (1) : 1 -9
再论分子生药学——三十年,一个新起点
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黄璐琦* , 郑汉, 袁媛, 郭娟
作者信息
  • 中国中医科学院 道地药材品质保障与资源持续利用全国重点实验室,北京 100700
通讯作者:

*

黄璐琦,E-mail:
Molecular Pharmacognosy revisited: charting a new course after three decades
Lu-qi HUANG* , Han ZHENG, Yuan YUAN, Juan GUO
Affiliations
  • State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing 100700, China
出版时间: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20251212.412
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分子生药学自1995年概念提出至今三十年来,已从概念萌芽成长为一门理论体系完善、技术方法成熟、应用范围广泛的前沿交叉学科。该文系统回顾了该学科在理论创新、技术标准、产业应用及平台建设等方面的重要进展,包括生药分子鉴定技术标准、道地药材形成机制解析、珍稀资源保护模式建立、活性成分生物合成等领域的突破性成果;阐述了分子生药学从学科和产业存在的现象为起点,通过“问题衍生—假说预设—技术创新—理论丰富”的递进过程,形成了一个在理论与实践相互作用下不断演进的学科研究范式;分析了当前在分子鉴定精度、道地性形成机制、资源可持续利用等方面仍面临的挑战。展望未来,分子生药学将与人工智能、全景组学、量子计算、生物制造、智能育种与基因编辑等前沿技术深度融合,推动研究范式从“认识与揭示”向“预测与设计”的革命性转变,迈向精准化、系统化与工程化的新起点,为中医药现代化注入全新动力。

分子生药学  /  学科演进  /  道地药材  /  人工智能  /  生物制造  /  智能育种

Since its conceptual inception in 1995, Molecular Pharmacognosy has evolved over three decades from a nascent idea into a frontier interdisciplinary discipline characterized by a comprehensive theoretical system, mature methodologies, and extensive applications. This paper systematically reviews the significant milestones of this discipline in theoretical innovation, technical standardization, industrial application, and platform construction. It highlights breakthrough achievements in areas such as technical standards for the molecular identification of crude drugs, elucidation of the formation mechanisms of Dao-di herbs, establishment of conservation models for rare and endangered resources, and biosynthesis of active compounds. The paper further elucidates the evolutionary research paradigm of Molecular Pharmacognosy. Originating from phenomena observed in both the discipline and the industry, this paradigm advances through a progressive cycle of problem derivation—hypothesis presupposition—technical innovation—theoretical enrichment, driven by the dynamic interplay between theory and practice. Furthermore, the paper analyzes current challenges regarding the precision of molecular identification, the complex mechanisms of geo-authenticity, and the sustainable utilization of resources. Molecular Pharmacognosy is poised to integrate deeply with frontier technologies such as artificial intelligence, pan-omics, quantum computing, biomanufacturing, smart breeding, and gene editing. This integration will drive a revolutionary shift in the research paradigm from recognition and revelation to prediction and design. Ultimately, these achievements will mark a new phase defined by precision, systematization, and engineering, injecting fresh momentum into the modernization of TCM.

Molecular Pharmacognosy  /  disciplinary evolution  /  Dao-di herbs  /  artificial intelligence  /  biomanufacturing  /  smart breeding
黄璐琦, 郑汉, 袁媛, 郭娟. 再论分子生药学——三十年,一个新起点. 中国中药杂志, 2026 , 51 (1) : 1 -9 . DOI: 10.19540/j.cnki.cjcmm.20251212.412
Lu-qi HUANG, Han ZHENG, Yuan YUAN, Juan GUO. Molecular Pharmacognosy revisited: charting a new course after three decades[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 1 -9 . DOI: 10.19540/j.cnki.cjcmm.20251212.412
  • 国家自然科学基金项目(82474040)
  • 中国中医科学院研究生课程思政建设项目(KCSZ24001)
  • 中央本级重大增减支项目(2060302)
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2026年第51卷第1期
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doi: 10.19540/j.cnki.cjcmm.20251212.412
  • 接收时间:2025-11-25
  • 首发时间:2026-06-25
  • 出版时间:2026-01-01
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  • 收稿日期:2025-11-25
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国家自然科学基金项目(82474040)
中国中医科学院研究生课程思政建设项目(KCSZ24001)
中央本级重大增减支项目(2060302)
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    中国中医科学院 道地药材品质保障与资源持续利用全国重点实验室,北京 100700

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2种不同金属材料的力学参数

Family
属数
Number of
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种数
Number of
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占总种数比例
Percentage of
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Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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