Article(id=1276975978186412437, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20250925.301, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747670400000, receivedDateStr=2025-05-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384398266, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384398266, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384398266, creator=13701087609, updateTime=1782384398266, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=83, endPage=91, ext={EN=ArticleExt(id=1276975978559705495, articleId=1276975978186412437, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Effect of decoction method on phase state and biological activity of Cinnamomi Cortex-Coptidis Rhizoma supramolecular, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Based on supramolecular chemistry of TCM, this study investigated the interaction between Cinnamomi Cortex-Coptidis Rhizoma herb pair and compared phase states and bioactivity differences under different decoction methods (co-decoction vs individual decoction followed by mechanical mixing). Phase state variations were observed macroscopically and through turbidimetry. The herb interaction was analyzed using isothermal titration calorimetry, UV and IR spectroscopy. Particle size differences were determined by dynamic light scattering and scanning electron microscopy (SEM). Antimicrobial activity was evaluated through broth dilution, plate coating, live/dead staining, and SEM. Component analysis was conducted using UPLC-MS/MS. Results revealed distinct supramolecular structures in Cinnamomi Cortex-Coptidis Rhizoma decoctions, with co-decoction showing more stable macroscopic phase states. The interaction was a spontaneous exothermic reaction driven by both entropy and enthalpy. UV and IR spectra revealed co-decoction demonstrated more sufficient molecular interactions, more stable supramolecular structures, and smaller particle sizes with a more centralized distribution. In addition, co-decoction resulted in higher berberine and coptisine content and stronger inhibitory activity against Staphylococcus aureus compared to mechanical mixtures. These findings indicated that co-decoction produced Cinnamomi Cortex-Coptidis Rhizoma supramolecular systems with more homogeneous phase states, enhanced measurable coptisine and berberine content, and superior antibacterial efficacy.

, authors=null, authorsList=Ran XU, Zhi-jia WANG, Xiao-yu LIN, Ji-chang WEI, Yi-hang ZHAO, Xin-ru TAN, Zhi-xia WANG, Liu-yang ZHANG, Hong-li WANG, Xue-mei HUANG, Peng-long WANG, authorCompany=null, correspAuthors=Xue-mei HUANG, Peng-long WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276975979117547930, articleId=1276975978186412437, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=煎煮方式对肉桂-黄连药对超分子的物质相态和生物活性的影响, columnId=1276975978656174488, journalTitle=中国中药杂志, columnName=制剂与炮制, runingTitle=null, highlight=null, articleAbstract=

基于中药超分子化学探讨肉桂-黄连药效成分的相互作用，对比该药对体系在不同煎煮方式下（共同煎煮、单煎再机械混合）的相态和活性差异。通过宏观和比浊法观察该药对不同煎煮下汤剂相态差异；运用等温滴定量热法、紫外与红外光谱分析肉桂-黄连的相互作用；利用动态光散射法和扫描电镜测定不同煎煮方式下汤剂粒径差异；结合肉汤稀释法、平板涂布、活死菌染色和扫描电镜进行活性评价；最后使用UPLC-MS/MS进行成分分析。结果显示肉桂-黄连药对汤剂存在明显的超分子体系，且共同煎煮组的宏观相态更稳定。该药对相互作用是熵和焓共同驱动的自发放热反应；紫外与红外光谱说明共煎体系药效分子相互作用更加充分，超分子结构更稳定，且粒径更小，分布更集中。共煎样品中小檗碱和黄连碱含量高于机械混合样品，对金黄色葡萄球菌有更强的抑制活性。结果表明，共同煎煮下的肉桂-黄连超分子体系相态更均匀、可测黄连碱和小檗碱含量更高、抗菌活性更强。

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徐冉，硕士研究生，E-mail: pipigou06@163.com

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