Article(id=1276975992317019009, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251021.302, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753891200000, receivedDateStr=2025-07-31, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384401635, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384401635, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384401635, creator=13701087609, updateTime=1782384401635, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=10, endPage=18, ext={EN=ArticleExt(id=1276975992803558275, articleId=1276975992317019009, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Research progress on novel technologies and evaluation methods for nasal drug delivery, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Focused on the challenges in brain disease treatment and advancements in nose-to-brain delivery research, this article summarized current progress in nasal drug delivery research and proposed several novel evaluation models for nasal drug absorption. By reviewing five types of evaluation models-ex vivo animal tissue models, in situ perfusion models, in vivo pharmacokinetic models, in vitro cell models, and computational fluid dynamics model-it clarified the distinct advantages of nasal drug delivery compared to other administration routes. Furthermore, by outlining emerging nasal drug delivery technologies and irritation evaluation methods, it explored the cutting-edge directions of nose-to-brain delivery. This provides essential support for the selection of nose-to-brain delivery dosage forms and paves new paths for the advancement of nasal drug delivery.

, authors=null, authorsList=Lin LI, Hui-hui DU, Yan-xun LIU, Xiao-yu FAN, Jin-hong YE, Hui-juan SHEN, Peng-yue LI, Shou-ying DU, authorCompany=null, correspAuthors=Peng-yue LI, Shou-ying DU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276975993906660229, articleId=1276975992317019009, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=药物经鼻递送新技术及评价技术研究进展, columnId=1276975957151977760, journalTitle=中国中药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

针对脑部疾病治疗的难题及鼻脑递送相关研究发展，对现阶段经鼻给药研究进展进行总结，提出多种药物鼻腔吸收新型评价模型。通过对离体动物组织模型、在体灌流模型、体内药动学模型、体外细胞模型、计算流体力学模型5种评价模型进行总结，阐明鼻腔给药相较于其他给药方式，有较为明显的优势；通过概述鼻腔给药新技术及刺激性评价，了解药物鼻脑递送的前沿方向，为后续鼻脑递送药物剂型选择提供必要支撑，为鼻腔给药发展开拓新的道路。

, authors=, authorsList=李琳, 杜慧慧, 刘彦洵, 樊箫雨, 叶津宏, 沈慧娟, 李鹏跃, 杜守颖, authorCompany=null, correspAuthors=李鹏跃, 杜守颖, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=c5NYg6AyC3bam8uqZmlp5Q==, magXml=3oXk3L/nmfifjEszOMRssg==, pdfUrl=null, pdf=wB+SPzTecjHMzEg0jNxMZA==, pdfFileSize=328923, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Ogyg32teBauuzI4MYPDJ/g==, mapNumber=null, fund=null)}, authors=[Author(id=1276975994443531147, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276975992317019009, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=20240935100@bucm.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1276975994514834317, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276975992317019009, authorId=1276975994443531147, language=EN, stringName=Lin LI, firstName=Lin, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276975994745521038, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276975992317019009, authorId=1276975994443531147, language=CN, stringName=李琳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京中医药大学 中药学院，北京 102488, bio={"content":"

李琳，硕士研究生，主要从事中药新剂型与新技术研究，E-mail: 20240935100@bucm.edu.cn

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李琳，硕士研究生，主要从事中药新剂型与新技术研究，E-mail: 20240935100@bucm.edu.cn

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