Article(id=1276975956803850525, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251011.708, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758038400000, receivedDateStr=2025-09-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384393167, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384393167, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384393167, creator=13701087609, updateTime=1782384393167, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=32, endPage=39, ext={EN=ArticleExt(id=1276975957009371423, articleId=1276975956803850525, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Application progress of germ-free animal models in colorectal cancer and traditional Chinese medicine research, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Colorectal cancer (CRC) is a highly prevalent malignant tumor worldwide, and its occurrence and development are closely related to gut microbiota disturbance. The germ-free (GF) animal model, by providing a unique environment free of indigenous microorganisms, has become a tool for precisely dissecting the causal role and mechanism of the gut microbiota in the occurrence and development of CRC and the therapeutic mechanisms of pharmaceuticals. This review aims to systematically elaborate on the application progress of GF animal models in CRC research, with a focus on the key mechanisms by which specific microorganisms promote the occurrence and development of CRC revealed by this model. Furthermore, this review focuses on the research dynamics of TCM in this field and systematically expounds the application of GF models in the research of TCM against CRC. Through in-depth analysis of the GF animal models of CRC, it is possible to develop precise diagnostic and therapeutic strategies based on TCM and the microbiome in the future, providing new directions and ideas for the prevention and treatment of CRC.

, authors=null, authorsList=Zi-xing QIAN, Jia-xuan LI, Xian-jun RAO, Guo-dong HUANG, Ran LIU, Wei WEI, authorCompany=null, correspAuthors=Wei WEI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276975957332332834, articleId=1276975956803850525, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=无菌动物模型在结直肠癌及中医药研究中的应用进展, columnId=1276975957151977760, journalTitle=中国中药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

结直肠癌（CRC）是全球高发的恶性肿瘤，其发生发展与肠道菌群紊乱密切相关。无菌（GF）动物模型通过提供无固有微生物的独特环境，成为精准解析肠道菌群在CRC发生、发展中因果作用及药物疗效机制的工具。该综述旨在系统阐述GF动物模型在CRC研究中的应用进展，重点总结利用该模型揭示的特定微生物促进CRC发生发展的关键机制。同时聚焦中医药在该领域的研究动态，系统阐述GF动物模型在中医药抗CRC研究中的应用。通过对CRC无菌动物模型的深入解析，未来可能开发出基于中医药、微生物组的精准诊断和治疗策略，为CRC的防治提供新的方向和思路。

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钱紫星，博士研究生，主要从事中医药防治消化系统疾病研究，E-mail: qianzixing0@163.com

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钱紫星，博士研究生，主要从事中医药防治消化系统疾病研究，E-mail: qianzixing0@163.com

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