Article(id=1276976182901997617, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251010.204, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1745337600000, receivedDateStr=2025-04-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384447074, onlineDateStr=2026-06-25, pubDate=1768406400000, pubDateStr=2026-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384447074, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384447074, creator=13701087609, updateTime=1782384447074, updator=13701087609, issue=Issue{id=1276976057215488893, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='2', pageStart='301', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1768406400000', pubDateStr='2026-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782384417107, creator='13701087609', updateTime=1782384524478, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976507658563977, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976507658563978, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=565, endPage=578, ext={EN=ArticleExt(id=1276976183199793203, articleId=1276976182901997617, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Metabolic profiling and pharmacokinetic studies of Gardeniae Fructus aqueous extracts by UHPLC-ESI-Q-TOF-MS/MS and UHPLC-QQQ-MS/MS, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Gardeniae Fructus (GF) is one of the most commonly used medicinal and edible resources in China, renowned for its anti-inflammatory and antipyretic effects. However, studies of the chemical characteristics, metabolic transformation and pharmacokinetic behavior of GF in vivo remain incomplete. This study utilized mass defect filtering (MDF) combined with UHPLC-ESI-Q-TOF-MS/MS to analyze the in vitro chemical constituents of GF aqueous extracts and its metabolites in vivo in rats, comprehensively characterizing 114 chemical constituents and 181 endogenous substances, including 18 prototype constituents and 163 metabolites (21 phase Ⅰ and 142 phase Ⅱ metabolites). Additionally, a quantitative method using UHPLC-QQQ-MS/MS was developed to analyze the in vivo dynamics of seven bioactive compounds, and the pharmacokinetic parameters of the main active components in the GF aqueous extracts, namely geniposidic acid, deacetyl asperulosidic acid methyl ester, gardenoside, genipin, genipin 1-β-D-gentiobioside, geniposide, and crocetin, were obtained. This study conducted a comprehensive and systematic investigation into the potential material basis and the in vivo biotransformation profile of GF aqueous extracts based on UHPLC-ESI-Q-TOF-MS/MS coupled with MDF technology and UHPLC-QQQ-MS/MS, providing crucial evidence for further elucidating its pharmacological mechanisms.

, authors=null, authorsList=Jiang HE, Wen-xin SHI, Shi-qi WANG, Pu-yang GONG, Yi HONG, Yu-jie GUO, authorCompany=null, correspAuthors=Yi HONG, Yu-jie GUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976183917019190, articleId=1276976182901997617, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=基于UHPLC-ESI-Q-TOF-MS/MS和UHPLC-QQQ-MS/MS的栀子水提物代谢轮廓分析和药代动力学研究, columnId=1276976183518560308, journalTitle=中国中药杂志, columnName=药代动力学, runingTitle=null, highlight=null, articleAbstract=

栀子是我国最常用的药食同源资源之一，具有抗炎和解热等功效，然而，有关栀子在体内的化学特征、代谢转化和药代动力学行为的研究尚不全面。该研究采用质量亏损过滤（mass defect filtering, MDF）技术，结合UHPLC-ESI-Q-TOF-MS/MS对栀子水提物的体外化学成分和大鼠体内代谢轮廓进行分析，全面表征了114个化学成分和181个体内外源性相关物质，包括18个原型成分和163个外源性代谢产物（21个Ⅰ相代谢物和142个Ⅱ相代谢物）。同时，建立UHPLC-QQQ-MS/MS定量方法对其中7种活性成分的体内动态过程进行分析，获得了栀子水提物体内主要活性成分京尼平苷酸、去乙酰车叶草苷酸甲酯、羟异栀子苷、京尼平、京尼平龙胆双糖苷、京尼平苷和西红花酸的药代动力学参数。该研究基于UHPLC-ESI-Q-TOF-MS/MS结合MDF技术和UHPLC-QQQ-MS/MS对栀子水提物的潜在药效物质基础及其体内生物转化轮廓进行了全面系统的研究，为进一步进行药理机制研究提供了重要依据。

, authors=, authorsList=何江, 史雯馨, 王诗琪, 龚普阳, 洪怡, 郭瑜婕, authorCompany=null, correspAuthors=洪怡, 郭瑜婕, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=x6zfFH+8B70rDSB9r7YLEg==, magXml=VjKCW1BzIjZWgWvD5rL1Mg==, pdfUrl=null, pdf=zv7wps8EEy//77LyKpycTA==, pdfFileSize=1236396, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=zttAc1qGrA002AD9ZKSfCg==, mapNumber=null, fund=null)}, authors=[Author(id=1276976184806211652, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=3171335247@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1276976184873320519, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976184806211652, language=EN, stringName=Jiang HE, firstName=Jiang, middleName=null, lastName=HE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276976184944623688, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976184806211652, language=CN, stringName=何江, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065, bio={"content":"

何江，硕士研究生，E-mail: 3171335247@qq.com

"}, bioImg=null, bioContent=

何江，硕士研究生，E-mail: 3171335247@qq.com

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1276976184135123000, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=1., ext=[AuthorCompanyExt(id=1276976184332255289, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China), AuthorCompanyExt(id=1276976184340643898, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065)])]), Author(id=1276976185179504714, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1276976185590546508, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976185179504714, language=EN, stringName=Wen-xin SHI, firstName=Wen-xin, middleName=null, lastName=SHI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276976185678626893, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976185179504714, language=CN, stringName=史雯馨, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1276976184135123000, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=1., ext=[AuthorCompanyExt(id=1276976184332255289, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China), AuthorCompanyExt(id=1276976184340643898, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065)])]), Author(id=1276976186022559823, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1276976186119028817, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976186022559823, language=EN, stringName=Shi-qi WANG, firstName=Shi-qi, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276976186500710482, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976186022559823, language=CN, stringName=王诗琪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1276976184135123000, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=1., ext=[AuthorCompanyExt(id=1276976184332255289, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China), AuthorCompanyExt(id=1276976184340643898, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065)])]), Author(id=1276976186874003540, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1276976186936918102, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976186874003540, language=EN, stringName=Pu-yang GONG, firstName=Pu-yang, middleName=null, lastName=GONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.School of Pharmacy, Southwest Minzu University, Chengdu 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276976187264073815, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976186874003540, language=CN, stringName=龚普阳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3．西南民族大学 药学院，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1276976184500027455, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=3., ext=[AuthorCompanyExt(id=1276976184508416064, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184500027455, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.School of Pharmacy, Southwest Minzu University, Chengdu 610041, China), AuthorCompanyExt(id=1276976184516804673, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184500027455, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3．西南民族大学 药学院，四川 成都 610041)])]), Author(id=1276976187347959897, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=46447564@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1276976187708670044, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976187347959897, language=EN, stringName=Yi HONG, firstName=Yi, middleName=null, lastName=HONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
^2.Hubei Shizhen Laboratory, Wuhan 430065, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276976187779973213, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976187347959897, language=CN, stringName=洪怡, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065
^2．湖北时珍实验室，湖北 武汉 430065, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1276976184135123000, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=1., ext=[AuthorCompanyExt(id=1276976184332255289, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China), AuthorCompanyExt(id=1276976184340643898, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065)]), AuthorCompany(id=1276976184411947067, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=2., ext=[AuthorCompanyExt(id=1276976184416141372, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184411947067, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Hubei Shizhen Laboratory, Wuhan 430065, China), AuthorCompanyExt(id=1276976184424529981, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184411947067, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2．湖北时珍实验室，湖北 武汉 430065)])]), Author(id=1276976188115517535, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=guoyujie2018@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1276976188203597922, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976188115517535, language=EN, stringName=Yu-jie GUO, firstName=Yu-jie, middleName=null, lastName=GUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
^2.Hubei Shizhen Laboratory, Wuhan 430065, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276976188539142243, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, authorId=1276976188115517535, language=CN, stringName=郭瑜婕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065
^2．湖北时珍实验室，湖北 武汉 430065, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1276976184135123000, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=1., ext=[AuthorCompanyExt(id=1276976184332255289, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China), AuthorCompanyExt(id=1276976184340643898, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065)]), AuthorCompany(id=1276976184411947067, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=2., ext=[AuthorCompanyExt(id=1276976184416141372, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184411947067, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Hubei Shizhen Laboratory, Wuhan 430065, China), AuthorCompanyExt(id=1276976184424529981, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184411947067, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2．湖北时珍实验室，湖北 武汉 430065)])])], keywords=[Keyword(id=1276976188639805540, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=EN, orderNo=1, keyword=Gardeniae Fructus aqueous extracts), Keyword(id=1276976189000515685, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=EN, orderNo=2, keyword=metabolic profiling), Keyword(id=1276976189092790374, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=EN, orderNo=3, keyword=pharmacokinetics), Keyword(id=1276976189378003047, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=EN, orderNo=4, keyword=UHPLC-ESI-Q-TOF-MS/MS), Keyword(id=1276976189457694824, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=EN, orderNo=5, keyword=UHPLC-QQQ-MS/MS), Keyword(id=1276976189801627753, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=CN, orderNo=1, keyword=栀子水提物), Keyword(id=1276976189893902442, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=CN, orderNo=2, keyword=代谢轮廓), Keyword(id=1276976190275584107, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=CN, orderNo=3, keyword=药代动力学), Keyword(id=1276976190661460076, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=CN, orderNo=4, keyword=UHPLC-ESI-Q-TOF-MS/MS), Keyword(id=1276976191038947437, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, language=CN, orderNo=5, keyword=UHPLC-QQQ-MS/MS)], refs=null, funds=[Fund(id=1276976191147999342, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, awardId=82204750, language=CN, fundingSource=国家自然科学基金青年科学基金项目(82204750), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1276976184135123000, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=1., ext=[AuthorCompanyExt(id=1276976184332255289, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Center for Pharmaceutical Formulations, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China), AuthorCompanyExt(id=1276976184340643898, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184135123000, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1．湖北中医药大学 药学院 药物制剂中心，湖北 武汉 430065)]), AuthorCompany(id=1276976184411947067, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=2., ext=[AuthorCompanyExt(id=1276976184416141372, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184411947067, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Hubei Shizhen Laboratory, Wuhan 430065, China), AuthorCompanyExt(id=1276976184424529981, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184411947067, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2．湖北时珍实验室，湖北 武汉 430065)]), AuthorCompany(id=1276976184500027455, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, xref=3., ext=[AuthorCompanyExt(id=1276976184508416064, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184500027455, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.School of Pharmacy, Southwest Minzu University, Chengdu 610041, China), AuthorCompanyExt(id=1276976184516804673, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976182901997617, companyId=1276976184500027455, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3．西南民族大学 药学院，四川 成都 610041)])], figs=null, attaches=null, journal=Journal(id=1276576774675730453, delFlag=0, nameCn=中国中药杂志, nameEn=Chinese Journal of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, issn=1001-5302, eissn=2097-5066, cn=11-2272/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=Wp+xVi2pFpMjZtgAvUPqBA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Traditional Chinese Medicine, journalRemark=null, publicationField=null, createdTime=1782289220734, updatedTime=1784021766041, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=Wp+xVi2pFpMjZtgAvUPqBA==, picEn=+6LpkbuqcMxcXTbcXC5SRA==, jcr=null, cjcr=null, exts=[JournalExt(id=1283843596482744979, language=CN, name=中国中药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784021766062, updatedTime=1784021766062, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://cacm.tcmjc.com/CJCMM, submissionEditorUrl=https://cacm.tcmjc.com/CJCMM, submissionReviewUrl=https://cacm.tcmjc.com/CJCMM, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1283843596537270932, language=EN, name=Chinese Journal of Traditional Chinese Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784021766075, updatedTime=1784021766075, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://cacm.tcmjc.com/CJCMM, submissionEditorUrl=https://cacm.tcmjc.com/CJCMM, submissionReviewUrl=https://cacm.tcmjc.com/CJCMM, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1276577828834349082, websiteList=[Website(id=1276578024996864213, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1276577828834349082, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgzyzz/CN, language=CN, createTime=1782289518832, createBy=18614031015, updateTime=1782290501435, updateBy=18614031015, name=中国中药杂志-中文, tplId=1146099689490845704, title=中国中药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1276582276515369131, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=articleTextType, value=kx, createTime=1782290532473, updateTime=1782290532473, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276490203304, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=banner, value=null, createTime=1782290532467, updateTime=1782290532467, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276536340654, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=grayFlag, value=0, createTime=1782290532478, updateTime=1782290532478, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276477620391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=logo, value=https://castjournals.cast.org.cn/joweb/zgzyzz/CN/file/pic?fileId=tqs6u8GE413e8rN+h8xxag==, createTime=1782290532464, updateTime=1782290532464, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276548923568, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=minRunFlag, value=0, createTime=1782290532481, updateTime=1782290532481, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276506980522, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgzyzz/CN/file/pic, createTime=1782290532471, updateTime=1782290532471, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276540534959, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=silenceFlag, value=0, createTime=1782290532479, updateTime=1782290532479, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276498591913, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1782290532469, updateTime=1782290532469, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276523757740, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=themeColor, value=null, createTime=1782290532475, updateTime=1782290532475, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582276527952045, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578024996864213, code=themeStyle, value=null, createTime=1782290532476, updateTime=1782290532476, creator=18614031015, updator=18614031015)]), Website(id=1276578025101721818, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1276577828834349082, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgzyzz/EN, language=EN, createTime=1782289518857, createBy=18614031015, updateTime=1782290498024, updateBy=18614031015, name=中国中药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Traditional Chinese Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1276582244294725793, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=articleTextType, value=kx, createTime=1782290524791, updateTime=1782290524791, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244269559966, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=banner, value=null, createTime=1782290524785, updateTime=1782290524785, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244328280228, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=grayFlag, value=0, createTime=1782290524799, updateTime=1782290524799, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244256977053, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=logo, value=https://castjournals.cast.org.cn/joweb/zgzyzz/EN/file/pic?fileId=tqs6u8GE413e8rN+h8xxag==, createTime=1782290524782, updateTime=1782290524782, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244345057446, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=minRunFlag, value=0, createTime=1782290524803, updateTime=1782290524803, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244286337184, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgzyzz/EN/file/pic, createTime=1782290524789, updateTime=1782290524789, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244336668837, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=silenceFlag, value=0, createTime=1782290524801, updateTime=1782290524801, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244277948575, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1782290524787, updateTime=1782290524787, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244303114402, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=themeColor, value=null, createTime=1782290524793, updateTime=1782290524793, creator=18614031015, updator=18614031015), WebsiteProps(id=1276582244315697315, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1276578025101721818, code=themeStyle, value=null, createTime=1782290524796, updateTime=1782290524796, creator=18614031015, updator=18614031015)])], journalTitle=中国中药杂志, weixinUrl=null, journalUrl=https://www.tcmjc.com/zgzy, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Traditional Chinese Medicine, journalPhotoCn=Wp+xVi2pFpMjZtgAvUPqBA==, journalPhotoEn=+6LpkbuqcMxcXTbcXC5SRA==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgzyzz/CN/10.19540/j.cnki.cjcmm.20251010.204, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgzyzz/EN/10.19540/j.cnki.cjcmm.20251010.204, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgzyzz/CN/PDF/10.19540/j.cnki.cjcmm.20251010.204, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgzyzz/EN/PDF/10.19540/j.cnki.cjcmm.20251010.204, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1768406400000, fullTextJson=null, articleText=null, reference=null)