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Article(id=1276976114601951871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251010.203, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1748880000000, receivedDateStr=2025-06-03, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384430790, onlineDateStr=2026-06-25, pubDate=1768406400000, pubDateStr=2026-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384430790, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384430789, creator=13701087609, updateTime=1782384430789, updator=13701087609, issue=Issue{id=1276976057215488893, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='2', pageStart='301', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1768406400000', pubDateStr='2026-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782384417107, creator='13701087609', updateTime=1782384524478, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976507658563977, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976507658563978, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=371, endPage=381, ext={EN=ArticleExt(id=1276976114908136065, articleId=1276976114601951871, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Research progress in signaling pathways involved in traditional Chinese medicine treatment of attention deficit hyperactivity disorder, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Attention deficit hyperactivity disorder (ADHD), a common neurodevelopmental disorder in children, is characterized by inattention, hyperactivity, and impulsivity. Epidemiological surveys show that the prevalence of ADHD in children is gradually increasing worldwide, and it is the most common childhood mental disorder in China. Because of the complex clinical symptoms, multiple co-morbidities, and unknown etiology, ADHD has far-reaching negative impacts on individuals, families, and the society. Behavioral interventions, as a pillar in the management of ADHD, play a targeted role in improving children's social functioning, with significant benefits supported by evidence. However, they are constrained by uneven resources, poor compliance, and insufficient continuity, Western medicine has multiple adverse effects and unclear long-term effects in the treatment of ADHD despite the definite efficacy. Accordingly, there is an urgent need to find safe and effective therapies suitable for children. With a holistic view and treatment based on syndrome differentiation, traditional Chinese medicine (TCM) has significant advantages in treating ADHD via multiple targets, which involves dopamine (DA), norepinephrine (NE), 5-hydroxytryptamine (5-HT), cyclic adenosine monophosphate (cAMP), brain-derived neurotrophic factor (BDNF) and other signaling pathways. Through these pathways, TCM can treat ADHD through the regulation of neurotransmitters, enhancement of prefrontal and striatal functions, enhancement of neuronal protection, attenuation of neuroinflammation, and reduction of neuronal apoptosis. However, a systematic study remains to be conducted. This paper summarizes the signaling pathways related to the treatment of ADHD by TCM in the past two decades, aiming to provide reference for delving into the mechanism and exploring effective TCM prescriptions for ADHD in children and to give full play to the advantages of the efficacy and characteristics of TCM.

, authors=null, authorsList=Xi-yu ZHAO, Zhen-qi WU, Tian-yu ZHANG, Yi-chen LIN, Kang-le LIU, Xin-ye ZHANG, Zi WANG, authorCompany=null, correspAuthors=Zhen-qi WU, Zi WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976115247874691, articleId=1276976114601951871, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=中医药治疗注意力缺陷多动障碍作用机制相关信号通路的研究进展, columnId=1276975957151977760, journalTitle=中国中药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

注意力缺陷多动障碍（attention deficit hyperactivity disorder, ADHD）是一种儿童常见的神经发育障碍性疾病，特征表现为注意力不集中、多动和冲动。流行病学调查显示，全球儿童ADHD患病率呈现逐渐上升趋势，是我国最常见的儿童精神障碍疾病。因其临床症状复杂、共患病多、病因病机不明，对个人、家庭和社会产生深远的负面影响。行为干预作为ADHD管理的重要支柱，对患儿的社会功能可起到针对性的改善作用，具有循证支持的显著效益，但受限于资源不均、依从性差及持续性不足，临床应用西药治疗ADHD虽疗效确切但不良反应较多，长期影响不明确，因此亟需寻求安全有效且适用于儿童的治疗方法。中医药基于整体观念和辨证论治，通过多靶点协同治疗ADHD优势显著，涉及多巴胺（dopamine, DA）、去甲肾上腺素（norepinephrine, NE）、5-羟色胺（5-hydroxytryptamine, 5-HT）、环磷酸腺苷（cyclic adenosine monophosphate, cAMP）、脑源性神经营养因子（brain-derived neurotrophic factor, BDNF）等多种信号通路，可通过调节神经递质、提高前额叶及纹状体功能、增强神经元保护、减轻神经炎症、减少神经元凋亡等作用机制治疗ADHD。但尚未有系统的研究总结，故现就近二十年来中医药治疗ADHD的相关信号通路研究进行综述，为儿童ADHD中医药有效方药的机制研究及后期探索提供参考，充分发挥中医药疗效优势特色。

, authors=

赵奚玉，硕士研究生，E-mail:

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*

王子，博士，副主任医师，主要从事中医药防治小儿感染性疾病及脑系疾病的研究，E-mail: ；

*

吴振起，博士，主任医师，主要从事中医药防治小儿感染性疾病及脑系疾病的研究，E-mail:
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赵奚玉，硕士研究生，E-mail:

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赵奚玉，硕士研究生，E-mail:

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中医药治疗注意力缺陷多动障碍作用机制相关信号通路的研究进展
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赵奚玉 1 , 吴振起 2, 3, * , 张天宇 1 , 林一辰 1 , 刘康乐 1 , 张鑫业 1 , 王子 2, *
中国中药杂志 | 综述 2026,51(2): 371-381
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中国中药杂志 |综述 2026 , 51 (2) : 371 -381
中医药治疗注意力缺陷多动障碍作用机制相关信号通路的研究进展
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赵奚玉，硕士研究生，E-mail:

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赵奚玉1 , 吴振起2, 3, * , 张天宇1, 林一辰1, 刘康乐1, 张鑫业1, 王子2, *
作者信息
  • 1．辽宁中医药大学，辽宁 沈阳 110032
  • 2．辽宁中医药大学附属医院，辽宁 沈阳 110032
  • 3．沈阳市中医外感病重点实验室，辽宁 沈阳 110031
通讯作者:

*

王子，博士，副主任医师，主要从事中医药防治小儿感染性疾病及脑系疾病的研究，E-mail: ；

*

吴振起，博士，主任医师，主要从事中医药防治小儿感染性疾病及脑系疾病的研究，E-mail:
Research progress in signaling pathways involved in traditional Chinese medicine treatment of attention deficit hyperactivity disorder
Xi-yu ZHAO1 , Zhen-qi WU2, 3, * , Tian-yu ZHANG1, Yi-chen LIN1, Kang-le LIU1, Xin-ye ZHANG1, Zi WANG2, *
Affiliations
  • 1.Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China
  • 2.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China
  • 3.Shenyang Key Laboratory of Exogenous Diseases of Traditional Chinese Medicine, Shenyang 110031, China
出版时间: 2026-01-15 doi: 10.19540/j.cnki.cjcmm.20251010.203
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摘要
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注意力缺陷多动障碍（attention deficit hyperactivity disorder, ADHD）是一种儿童常见的神经发育障碍性疾病，特征表现为注意力不集中、多动和冲动。流行病学调查显示，全球儿童ADHD患病率呈现逐渐上升趋势，是我国最常见的儿童精神障碍疾病。因其临床症状复杂、共患病多、病因病机不明，对个人、家庭和社会产生深远的负面影响。行为干预作为ADHD管理的重要支柱，对患儿的社会功能可起到针对性的改善作用，具有循证支持的显著效益，但受限于资源不均、依从性差及持续性不足，临床应用西药治疗ADHD虽疗效确切但不良反应较多，长期影响不明确，因此亟需寻求安全有效且适用于儿童的治疗方法。中医药基于整体观念和辨证论治，通过多靶点协同治疗ADHD优势显著，涉及多巴胺（dopamine, DA）、去甲肾上腺素（norepinephrine, NE）、5-羟色胺（5-hydroxytryptamine, 5-HT）、环磷酸腺苷（cyclic adenosine monophosphate, cAMP）、脑源性神经营养因子（brain-derived neurotrophic factor, BDNF）等多种信号通路，可通过调节神经递质、提高前额叶及纹状体功能、增强神经元保护、减轻神经炎症、减少神经元凋亡等作用机制治疗ADHD。但尚未有系统的研究总结，故现就近二十年来中医药治疗ADHD的相关信号通路研究进行综述，为儿童ADHD中医药有效方药的机制研究及后期探索提供参考，充分发挥中医药疗效优势特色。

中医药  /  注意力缺陷多动障碍  /  作用机制  /  信号通路

Attention deficit hyperactivity disorder (ADHD), a common neurodevelopmental disorder in children, is characterized by inattention, hyperactivity, and impulsivity. Epidemiological surveys show that the prevalence of ADHD in children is gradually increasing worldwide, and it is the most common childhood mental disorder in China. Because of the complex clinical symptoms, multiple co-morbidities, and unknown etiology, ADHD has far-reaching negative impacts on individuals, families, and the society. Behavioral interventions, as a pillar in the management of ADHD, play a targeted role in improving children's social functioning, with significant benefits supported by evidence. However, they are constrained by uneven resources, poor compliance, and insufficient continuity, Western medicine has multiple adverse effects and unclear long-term effects in the treatment of ADHD despite the definite efficacy. Accordingly, there is an urgent need to find safe and effective therapies suitable for children. With a holistic view and treatment based on syndrome differentiation, traditional Chinese medicine (TCM) has significant advantages in treating ADHD via multiple targets, which involves dopamine (DA), norepinephrine (NE), 5-hydroxytryptamine (5-HT), cyclic adenosine monophosphate (cAMP), brain-derived neurotrophic factor (BDNF) and other signaling pathways. Through these pathways, TCM can treat ADHD through the regulation of neurotransmitters, enhancement of prefrontal and striatal functions, enhancement of neuronal protection, attenuation of neuroinflammation, and reduction of neuronal apoptosis. However, a systematic study remains to be conducted. This paper summarizes the signaling pathways related to the treatment of ADHD by TCM in the past two decades, aiming to provide reference for delving into the mechanism and exploring effective TCM prescriptions for ADHD in children and to give full play to the advantages of the efficacy and characteristics of TCM.

traditional Chinese medicine  /  attention deficit hyperactivity disorder  /  mechanism of action  /  signaling pathway
赵奚玉, 吴振起, 张天宇, 林一辰, 刘康乐, 张鑫业, 王子. 中医药治疗注意力缺陷多动障碍作用机制相关信号通路的研究进展. 中国中药杂志, 2026 , 51 (2) : 371 -381 . DOI: 10.19540/j.cnki.cjcmm.20251010.203
Xi-yu ZHAO, Zhen-qi WU, Tian-yu ZHANG, Yi-chen LIN, Kang-le LIU, Xin-ye ZHANG, Zi WANG. Research progress in signaling pathways involved in traditional Chinese medicine treatment of attention deficit hyperactivity disorder[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (2) : 371 -381 . DOI: 10.19540/j.cnki.cjcmm.20251010.203
基金
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  • 国家自然科学基金项目(81373687; 81874490; 82074494)
  • 沈阳市科技计划项目(22-321-32-19)
  • 辽宁省科学技术计划项目(2022-YGJC-81)
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doi: 10.19540/j.cnki.cjcmm.20251010.203
  • 接收时间：2025-06-03
  • 首发时间：2026-06-25
  • 出版时间：2026-01-15
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出版历史
  • 收稿日期：2025-06-03
基金
国家自然科学基金项目(81373687; 81874490; 82074494)
沈阳市科技计划项目(22-321-32-19)
辽宁省科学技术计划项目(2022-YGJC-81)
作者信息
    1．辽宁中医药大学，辽宁 沈阳 110032
    2．辽宁中医药大学附属医院，辽宁 沈阳 110032
    3．沈阳市中医外感病重点实验室，辽宁 沈阳 110031

通讯作者:

*

王子，博士，副主任医师，主要从事中医药防治小儿感染性疾病及脑系疾病的研究，E-mail: ；

*

吴振起，博士，主任医师，主要从事中医药防治小儿感染性疾病及脑系疾病的研究，E-mail:
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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