Article(id=1276976153155989525, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20251010.202, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749657600000, receivedDateStr=2025-06-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384439982, onlineDateStr=2026-06-25, pubDate=1768406400000, pubDateStr=2026-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384439982, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384439982, creator=13701087609, updateTime=1782384439982, updator=13701087609, issue=Issue{id=1276976057215488893, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='2', pageStart='301', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1768406400000', pubDateStr='2026-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782384417107, creator='13701087609', updateTime=1782384524478, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976507658563977, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976507658563978, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276976057215488893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=450, endPage=455, ext={EN=ArticleExt(id=1276976153340538903, articleId=1276976153155989525, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=A new chlorinated butenolide from endophytic fungus Aspergillus sp. FH-1 of Valeriana officinalis, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

This study aims to investigate the antifungal secondary metabolites produced by the endophytic fungus Aspergillus sp. FH-1 isolated from Valeriana officinalis via a high-salt rice medium. Compounds were isolated and purified by silica gel and ODS column chromatography, semi-preparative HPLC, and other techniques. The chemical structures were elucidated through analysis of physicochemical properties and spectroscopic data of nuclear magnetic resonance (NMR), infrared (IR), and mass spectrometry (MS). The inhibitory effects of all the compounds against Colletotrichum gloeosporioides were evaluated via the mycelial growth rate method. Eight compounds were obtained from the ethyl acetate extract of Aspergillus sp. FH-1. They were identified as asperchoried A (1), butyrolactone Ⅱ (2), isobutyrolactone Ⅱ (3), aspernolide A (4), butyrolactone Ⅴ (5), clavatone (6), 1-hydroxy-6,8-dimethoxy-3-methylanthracene-9,10-dione (7), and (S) -7-methoxy-2, 5-dimethyl-2, 3-dihydrobenzofuran-6-ol (8). Among them, compound 1 is a novel chlorinated butanolide derivative and was designated asperchoried A. Compounds 1, 2, 6, and 7 possessed inhibitory effects on C. gloeosporioides, with EC₅₀ values of 15.08, 77.19, 89.94, and 62.02 μg·mL^-1, respectively.

, authors=null, authorsList=Hao FAN, Xin WANG, Meng-xin YU, Yi-xuan WU, Li-yuan ZHAO, Ke-zhen ZHANG, Yu-ze LI, Wei WANG, Xiao-mei SONG, Dong-dong ZHANG, authorCompany=null, correspAuthors=Dong-dong ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976153567031321, articleId=1276976153155989525, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=缬草药材内生真菌Aspergillus sp. FH-1中1个新的氯代丁烯内酯类化合物, columnId=1276976014295167305, journalTitle=中国中药杂志, columnName=化学, runingTitle=null, highlight=null, articleAbstract=

研究缬草药材内生真菌Aspergillus sp. FH-1大米高盐培养基中抗真菌次生代谢产物及其抗菌活性。采用硅胶和ODS柱色谱以及半制备液相色谱等方法进行分离纯化，并结合其理化性质及NMR、IR、MS等波谱学技术进行结构解析。采用菌丝生长速率法测定所有化合物对番木瓜炭疽病菌Colletotrichum gloeosporioides的抗真菌活性。从Aspergillus sp. FH-1菌株的乙酸乙酯提取部位分离得到8个化合物，分别鉴定为asperchoried A（1）、butyrolactone Ⅱ（2）、isobutyrolactone Ⅱ（3）、aspernolide A（4）、butyrolactone Ⅴ（5）、clavatone（6）、1-羟基-6，8-二甲氧基-3-甲基蒽-9，10-二酮（7）、（S）-7-甲氧基-2，5-二甲基-2，3-二氢苯并呋喃-6-醇（8），其中化合物1为氯代丁烯内酯类新化合物。化合物1、2、6、7抑制番木瓜炭疽病菌活性的EC₅₀分别为15.08、77.19、89.94、62.02 μg·mL^-1，表现出抑制番木瓜炭疽病菌活性。

, authors=, authorsList=樊浩, 王鑫, 禹梦欣, 吴怡轩, 赵丽媛, 张可桢, 李玉泽, 王薇, 宋小妹, 张东东, authorCompany=null, correspAuthors=张东东, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=4v7NhwZiRrIXoAjMKTqlow==, magXml=p5giRRcTel5l+glOtBrsvw==, pdfUrl=null, pdf=gbUjQtKk3NvNxWJtVSiwTQ==, pdfFileSize=1055433, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=mxQg+tteRae/u0ELHgQvtQ==, mapNumber=null, fund=null)}, authors=[Author(id=1276976154003238943, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976153155989525, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=fanhao@sntcm.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1276976154078736418, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976153155989525, authorId=1276976154003238943, language=EN, stringName=Hao FAN, firstName=Hao, middleName=null, lastName=FAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1276976154229731363, tenantId=1146029695717560320, journalId=1276577828834349082, articleId=1276976153155989525, authorId=1276976154003238943, language=CN, stringName=樊浩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=陕西中医药大学 药学院 陕西省太白七药研究与应用重点研究室，陕西 咸阳 712046, bio={"content":"

樊浩，博士，实验师，主要从事中草药药效物质基础研究，E-mail: fanhao@sntcm.edu.cn

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樊浩，博士，实验师，主要从事中草药药效物质基础研究，E-mail: fanhao@sntcm.edu.cn

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