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Article(id=1276976042845803304, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, articleNumber=null, orderNo=null, doi=10.19540/j.cnki.cjcmm.20250914.401, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749225600000, receivedDateStr=2025-06-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782384413681, onlineDateStr=2026-06-25, pubDate=1767196800000, pubDateStr=2026-01-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782384413681, onlineIssueDateStr=2026-06-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782384413681, creator=13701087609, updateTime=1782384413681, updator=13701087609, issue=Issue{id=1276975955985961244, tenantId=1146029695717560320, journalId=1276577828834349082, year='2026', volume='51', issue='1', pageStart='1', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1767196800000', pubDateStr='2026-01-01', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1782384392973, creator='13701087609', updateTime=1782384484405, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1276976339546673871, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1276976339546673872, tenantId=1146029695717560320, journalId=1276577828834349082, issueId=1276975955985961244, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=202, endPage=210, ext={EN=ArticleExt(id=1276976043323953962, articleId=1276976042845803304, tenantId=1146029695717560320, journalId=1276577828834349082, language=EN, title=Chaihu Jia Longgu Muli Decoction alleviates myocardial fibrosis in rats with myocardial infarction through TGF-β1/Smads pathway, columnId=null, journalTitle=Chinese Journal of Traditional Chinese Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=

This study observed the effect of Chaihu Jia Longgu Muli Decoction on myocardial fibrosis in the rat model of myocardial infarction (MI) and explored the effect of this decoction on ventricular remodeling induced by myocardial fibrosis after MI based on transforming growth factor-β1 (TGF-β1)/Smad proteins (Smads) pathway, aiming to reveal the therapeutic mechanism of this decoction. MI model rats were established by coronary artery ligation and assigned into sham, model, and low-dose, medium-dose, and high-dose (2.09, 4.19, and 8.37 g·kg-1, respectively) Chaihu Jia Longgu Muli Decoction groups, with 10 rats in each group. Chaihu Jia Longgu Muli Decoction groups were administrated with the decoction at different doses by gavage, and the sham and model groups received an equal volume of distilled water once daily for 4 weeks. The cardiac function of rats after MI was assessed via echocardiography. Myocardial fiber deposition and collagen volume fraction (CVF) were observed by Sirius red staining and Masson staining. Ultrastructure changes of myocardial cells were observed by transmission electron microscopy. Creatine kinase isoenzymes (CK-MB), cardiac troponin T (cTnT), and soluble growth stimulation expressed gene 2 (sST2) levels were measured by ELISA. Western blot was employed to assess the protein levels of collagen Ⅰ (Col Ⅰ) and α-smooth muscle actin (α-SMA) associated with myocardial fibrosis, and TGF-β1, Smad3, and Smad7 associated with the TGF-β1/Smads pathway. Compared with the sham group, the model group had significantly decreased body weight, compromised cardiac function, abnormal ventricular structure, collagen fiber deposition, increased fibrosis area and CVF, seriously damaged ultrastructure of myocardium, a part of mitochondria being swollen or even ruptured, disarrangement and lysis of myofibril, and broken myotome and myofilament with emergence of space. Furthermore, the model group showed risen levels of cTnT, sST2 and CK-MB, obvious myocardial fibrosis, up-regulated protein levels of pro-fibrotic cytokines TGF-β1 and Smad3, down-regulated protein level of the inhibitory cytokine Smad7, and increased expression of myocardial fibrosis-related proteins Col Ⅰ and α-SMA. Compared with the model group, Chaihu Jia Longgu Muli Decoction groups showed increased body weight, improved cardiac function and ventricular structure, reduced collagen fiber deposition, fibrosis area, and CVF, intact ultrastructure of myocardium, normal mitochondrial structure, and well-arranged myofibril and myofilament. In addition, Chaihu Jia Longgu Muli Decoction groups presented declined cTnT, sST2, and CK-MB levels, down-regulated protein levels of TGF-β1 and Smad3, up-regulated protein level of Smad7, and reduced expression of Col Ⅰ and α-SMA. Chaihu Jia Longgu Muli Decoction may reduce excessive deposition of extracellular matrix by regulating the expression of proteins in the TGF-β1/Smads pathway, thereby alleviating myocardial fibrosis and ameliorating ventricular remodeling.

, authors=null, authorsList=Xiao-yuan WANG, Cui-ling ZHU, Lei JIANG, Yi-zhuo LI, Xiao-hui LI, Gang LIU, Yan-qin SUN, Miao-yu SONG, Chao-chong YUE, authorCompany=null, correspAuthors=Cui-ling ZHU, Yi-zhuo LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1276976044045374252, articleId=1276976042845803304, tenantId=1146029695717560320, journalId=1276577828834349082, language=CN, title=柴胡加龙骨牡蛎汤调控TGF-β1/Smads通路防治心肌梗死后大鼠心肌纤维化的研究, columnId=1276975994707775974, journalTitle=中国中药杂志, columnName=药理, runingTitle=null, highlight=null, articleAbstract=

观察柴胡加龙骨牡蛎汤对心肌梗死（MI）模型大鼠心肌纤维化损伤的改善作用，基于转化生长因子-β1（TGF-β1）/Smad同源物（Smads）通路探讨该方对MI后心肌纤维化引起的心室重构的影响，以期揭示其潜在的效用机制。采用冠脉结扎法建立大鼠MI模型，分为假手术组，模型组，柴胡加龙骨牡蛎汤低、中、高剂量组，每组10只。柴胡加龙骨牡蛎汤低、中、高剂量组分别以2.09、4.19、8.37 g·kg-1剂量灌胃，假手术组和模型组以等容积蒸馏水灌胃，每日1次，连续4周。采用心脏彩超检测MI后大鼠的心功能，天狼星红染色、Masson染色观察心肌纤维沉积情况及胶原容积分数（CVF），透射电镜观察心肌细胞超微结构变化，酶联免疫吸附测定法检测血清肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白T（cTnT）和可溶性生长刺激表达基因2蛋白（sST2）水平，蛋白免疫印迹法检测心肌纤维化相关蛋白α-平滑肌肌动蛋白（α-SMA）、Ⅰ型胶原蛋白（Col Ⅰ）表达，及TGF-β1/Smads通路相关蛋白TGF-β1、Smad3、Smad7的表达。与假手术组相比，模型组大鼠体质量、心功能明显下降，心室结构异常；胶原纤维沉积，纤维化面积增加，CVF升高；心肌超微结构损伤严重，部分线粒体出现肿胀甚至破裂，肌原纤维排列紊乱溶解，肌节及肌丝断裂出现空隙；cTnT、sST2和CK-MB水平升高，心肌纤维化明显；促纤维化细胞因子TGF-β1、Smad3蛋白表达增多，抑制纤维化细胞因子Smad7蛋白表达减少，心肌纤维化相关蛋白Col Ⅰ、α-SMA表达增加。与模型组相比，各给药组大鼠体质量增加，心功能明显升高，异常心室结构得到改善；胶原纤维沉积减轻，纤维化面积减少，CVF降低；心肌超微结构较完整，可见较正常的线粒体结构，肌原纤维及肌丝排列尚可；cTnT、sST2和CK-MB水平降低；TGF-β1、Smad3蛋白表达减少，Smad7蛋白表达升高，Col Ⅰ、α-SMA蛋白表达降低。综上，柴胡加龙骨牡蛎汤可能通过调控TGF-β1/Smads通路蛋白表达，进而减少细胞外基质的过度沉积，从而减轻心肌纤维化，改善心室重构。

, authors=

王潇媛，硕士研究生，E-mail:

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*

朱翠玲，硕士，主任医师，教授，主要从事中医药防治心血管疾病临床研究，E-mail: ；

*

李一卓，博士，主治医师，主要从事中医药防治心血管疾病临床研究，E-mail:
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柴胡加龙骨牡蛎汤调控TGF-β1/Smads通路防治心肌梗死后大鼠心肌纤维化的研究
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王潇媛 1, 3 , 朱翠玲 1, 2, * , 姜雷 1 , 李一卓 1, 2, * , 李晓辉 1, 2 , 刘刚 1, 2 , 孙彦琴 1, 2 , 宋淼豫 1 , 岳朝冲 1
中国中药杂志 | 药理 2026,51(1): 202-210
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中国中药杂志 |药理 2026 , 51 (1) : 202 -210
柴胡加龙骨牡蛎汤调控TGF-β1/Smads通路防治心肌梗死后大鼠心肌纤维化的研究
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王潇媛1, 3 , 朱翠玲1, 2, * , 姜雷1, 李一卓1, 2, * , 李晓辉1, 2, 刘刚1, 2, 孙彦琴1, 2, 宋淼豫1, 岳朝冲1
作者信息
  • 1．河南中医药大学 第一附属医院 心脏中心，河南 郑州 450000
  • 2．中西医防治重大疾病河南省协同创新中心，河南 郑州 450000
  • 3．河南中医药大学，河南 郑州 450046
通讯作者:

*

朱翠玲，硕士，主任医师，教授，主要从事中医药防治心血管疾病临床研究，E-mail: ；

*

李一卓，博士，主治医师，主要从事中医药防治心血管疾病临床研究，E-mail:
Chaihu Jia Longgu Muli Decoction alleviates myocardial fibrosis in rats with myocardial infarction through TGF-β1/Smads pathway
Xiao-yuan WANG1, 3 , Cui-ling ZHU1, 2, * , Lei JIANG1, Yi-zhuo LI1, 2, * , Xiao-hui LI1, 2, Gang LIU1, 2, Yan-qin SUN1, 2, Miao-yu SONG1, Chao-chong YUE1
Affiliations
  • 1.Cardiac Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
  • 2.Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan Province, Zhengzhou 450000, China
  • 3.Henan University of Chinese Medicine, Zhengzhou 450046, China
出版时间: 2026-01-01 doi: 10.19540/j.cnki.cjcmm.20250914.401
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观察柴胡加龙骨牡蛎汤对心肌梗死（MI）模型大鼠心肌纤维化损伤的改善作用，基于转化生长因子-β1（TGF-β1）/Smad同源物（Smads）通路探讨该方对MI后心肌纤维化引起的心室重构的影响，以期揭示其潜在的效用机制。采用冠脉结扎法建立大鼠MI模型，分为假手术组，模型组，柴胡加龙骨牡蛎汤低、中、高剂量组，每组10只。柴胡加龙骨牡蛎汤低、中、高剂量组分别以2.09、4.19、8.37 g·kg-1剂量灌胃，假手术组和模型组以等容积蒸馏水灌胃，每日1次，连续4周。采用心脏彩超检测MI后大鼠的心功能，天狼星红染色、Masson染色观察心肌纤维沉积情况及胶原容积分数（CVF），透射电镜观察心肌细胞超微结构变化，酶联免疫吸附测定法检测血清肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白T（cTnT）和可溶性生长刺激表达基因2蛋白（sST2）水平，蛋白免疫印迹法检测心肌纤维化相关蛋白α-平滑肌肌动蛋白（α-SMA）、Ⅰ型胶原蛋白（Col Ⅰ）表达，及TGF-β1/Smads通路相关蛋白TGF-β1、Smad3、Smad7的表达。与假手术组相比，模型组大鼠体质量、心功能明显下降，心室结构异常；胶原纤维沉积，纤维化面积增加，CVF升高；心肌超微结构损伤严重，部分线粒体出现肿胀甚至破裂，肌原纤维排列紊乱溶解，肌节及肌丝断裂出现空隙；cTnT、sST2和CK-MB水平升高，心肌纤维化明显；促纤维化细胞因子TGF-β1、Smad3蛋白表达增多，抑制纤维化细胞因子Smad7蛋白表达减少，心肌纤维化相关蛋白Col Ⅰ、α-SMA表达增加。与模型组相比，各给药组大鼠体质量增加，心功能明显升高，异常心室结构得到改善；胶原纤维沉积减轻，纤维化面积减少，CVF降低；心肌超微结构较完整，可见较正常的线粒体结构，肌原纤维及肌丝排列尚可；cTnT、sST2和CK-MB水平降低；TGF-β1、Smad3蛋白表达减少，Smad7蛋白表达升高，Col Ⅰ、α-SMA蛋白表达降低。综上，柴胡加龙骨牡蛎汤可能通过调控TGF-β1/Smads通路蛋白表达，进而减少细胞外基质的过度沉积，从而减轻心肌纤维化，改善心室重构。

心肌梗死  /  心肌纤维化  /  心室重构  /  柴胡加龙骨牡蛎汤  /  TGF-β1/Smads通路

This study observed the effect of Chaihu Jia Longgu Muli Decoction on myocardial fibrosis in the rat model of myocardial infarction (MI) and explored the effect of this decoction on ventricular remodeling induced by myocardial fibrosis after MI based on transforming growth factor-β1 (TGF-β1)/Smad proteins (Smads) pathway, aiming to reveal the therapeutic mechanism of this decoction. MI model rats were established by coronary artery ligation and assigned into sham, model, and low-dose, medium-dose, and high-dose (2.09, 4.19, and 8.37 g·kg-1, respectively) Chaihu Jia Longgu Muli Decoction groups, with 10 rats in each group. Chaihu Jia Longgu Muli Decoction groups were administrated with the decoction at different doses by gavage, and the sham and model groups received an equal volume of distilled water once daily for 4 weeks. The cardiac function of rats after MI was assessed via echocardiography. Myocardial fiber deposition and collagen volume fraction (CVF) were observed by Sirius red staining and Masson staining. Ultrastructure changes of myocardial cells were observed by transmission electron microscopy. Creatine kinase isoenzymes (CK-MB), cardiac troponin T (cTnT), and soluble growth stimulation expressed gene 2 (sST2) levels were measured by ELISA. Western blot was employed to assess the protein levels of collagen Ⅰ (Col Ⅰ) and α-smooth muscle actin (α-SMA) associated with myocardial fibrosis, and TGF-β1, Smad3, and Smad7 associated with the TGF-β1/Smads pathway. Compared with the sham group, the model group had significantly decreased body weight, compromised cardiac function, abnormal ventricular structure, collagen fiber deposition, increased fibrosis area and CVF, seriously damaged ultrastructure of myocardium, a part of mitochondria being swollen or even ruptured, disarrangement and lysis of myofibril, and broken myotome and myofilament with emergence of space. Furthermore, the model group showed risen levels of cTnT, sST2 and CK-MB, obvious myocardial fibrosis, up-regulated protein levels of pro-fibrotic cytokines TGF-β1 and Smad3, down-regulated protein level of the inhibitory cytokine Smad7, and increased expression of myocardial fibrosis-related proteins Col Ⅰ and α-SMA. Compared with the model group, Chaihu Jia Longgu Muli Decoction groups showed increased body weight, improved cardiac function and ventricular structure, reduced collagen fiber deposition, fibrosis area, and CVF, intact ultrastructure of myocardium, normal mitochondrial structure, and well-arranged myofibril and myofilament. In addition, Chaihu Jia Longgu Muli Decoction groups presented declined cTnT, sST2, and CK-MB levels, down-regulated protein levels of TGF-β1 and Smad3, up-regulated protein level of Smad7, and reduced expression of Col Ⅰ and α-SMA. Chaihu Jia Longgu Muli Decoction may reduce excessive deposition of extracellular matrix by regulating the expression of proteins in the TGF-β1/Smads pathway, thereby alleviating myocardial fibrosis and ameliorating ventricular remodeling.

myocardial infarction  /  myocardial fibrosis  /  ventricular remodeling  /  Chaihu Jia Longgu Muli Decoction  /  TGF-β1/Smads pathway
王潇媛, 朱翠玲, 姜雷, 李一卓, 李晓辉, 刘刚, 孙彦琴, 宋淼豫, 岳朝冲. 柴胡加龙骨牡蛎汤调控TGF-β1/Smads通路防治心肌梗死后大鼠心肌纤维化的研究. 中国中药杂志, 2026 , 51 (1) : 202 -210 . DOI: 10.19540/j.cnki.cjcmm.20250914.401
Xiao-yuan WANG, Cui-ling ZHU, Lei JIANG, Yi-zhuo LI, Xiao-hui LI, Gang LIU, Yan-qin SUN, Miao-yu SONG, Chao-chong YUE. Chaihu Jia Longgu Muli Decoction alleviates myocardial fibrosis in rats with myocardial infarction through TGF-β1/Smads pathway[J]. Chinese Journal of Traditional Chinese Medicine, 2026 , 51 (1) : 202 -210 . DOI: 10.19540/j.cnki.cjcmm.20250914.401
基金
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  • 国家中医药管理局2022年度张仲景传承与创新专项(GZY-KJS-2022-044-2)
  • 国家自然科学基金青年科学基金项目(82405290)
  • 河南省中医药科学研究专项(2023ZY2027)
  • 深圳市医疗卫生三名工程项目(SZZYSM202411009)
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doi: 10.19540/j.cnki.cjcmm.20250914.401
  • 接收时间：2025-06-07
  • 首发时间：2026-06-25
  • 出版时间：2026-01-01
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  • 收稿日期：2025-06-07
基金
国家中医药管理局2022年度张仲景传承与创新专项(GZY-KJS-2022-044-2)
国家自然科学基金青年科学基金项目(82405290)
河南省中医药科学研究专项(2023ZY2027)
深圳市医疗卫生三名工程项目(SZZYSM202411009)
作者信息
    1．河南中医药大学 第一附属医院 心脏中心，河南 郑州 450000
    2．中西医防治重大疾病河南省协同创新中心，河南 郑州 450000
    3．河南中医药大学，河南 郑州 450046

通讯作者:

*

朱翠玲，硕士，主任医师，教授，主要从事中医药防治心血管疾病临床研究，E-mail: ；

*

李一卓，博士，主治医师，主要从事中医药防治心血管疾病临床研究，E-mail:
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https://castjournals.cast.org.cn/joweb/zgzyzz/CN/10.19540/j.cnki.cjcmm.20250914.401
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
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