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Research progress on mechanism and treatment of anlotinib-related hypertension
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Ting-fei TAN1, Feng-qin ZHU1, Jun-ping WANG1, Shan GAO2
Chinese Pharmacological Bulletin | 2026, 42(5) : 801 - 805
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Chinese Pharmacological Bulletin | 2026, 42(5): 801-805
Research progress on mechanism and treatment of anlotinib-related hypertension
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Ting-fei TAN1, Feng-qin ZHU1, Jun-ping WANG1, Shan GAO2
Affiliations
  • 1Pharmacy Center, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230000, China
  • 2School of Pharmacy, Anhui Medical University, Hefei 230032, China
Published: 2026-05-20 doi: 10.12360/CPB202510040
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Hypertension is the most common adverse reaction associated with anlotinib during anti-tumor therapy, with an incidence rate as high as 76. 9%. More importantly, the occurrence and progression of hypertension and its complications significantly impair the quality of life for cancer patients, potentially leading to treatment discontinuation and increasing the risk of disease progression. Currently, research on anlotinibrelated hypertension remains limited. Given this, this paper primarily explores the specific mechanisms underlying anlotinibrelated hypertension and reviews its treatment strategies, aiming to provide a theoretical basis for individualized blood pressure management in clinical practice.

anlotinib  /  hypertension  /  nitric oxide  /  endothelin-1  /  oxidative stress  /  microvascular rarefaction  /  kidney injury
Ting-fei TAN, Feng-qin ZHU, Jun-ping WANG, Shan GAO. Research progress on mechanism and treatment of anlotinib-related hypertension[J]. Chinese Pharmacological Bulletin, 2026 , 42 (5) : 801 -805 . DOI: 10.12360/CPB202510040
Year 2026 volume 42 Issue 5
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doi: 10.12360/CPB202510040
  • Receive Date:2026-01-12
  • Online Date:2026-07-16
  • Published:2026-05-20
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  • Received:2026-01-12
  • Revised:2026-04-02
Affiliations
    1Pharmacy Center, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230000, China
    2School of Pharmacy, Anhui Medical University, Hefei 230032, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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