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Protein N-myristoylation is an important post-translational modification catalyzed by N-myristoyltransferase (NMT), which covalently attaches myristic acid to the N-terminal glycine residue of target proteins, thereby regulating their membrane localization, stability, and biological functions. This review aims to summarize the molecular mechanisms of protein N-myristoylation and its role in tumor progression, analyzing the abnormal expression patterns of protein N-myristoylation in tumors, its regulation of signaling pathways and metabolism, and its interactions with other post-translational modifications. The study shows that this modification is aberrantly expressed in multiple solid tumors such as hepatocellular carcinoma, lung cancer, breast cancer, and prostate cancer, and participates in regulating tumor cell proliferation, migration, drug resistance, and immune evasion.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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