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Research advances in pathogenesis of hypertension with comorbid depression
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Yi-yuan WANG1, 2, Lu-fan SHEN1, Nan WANG3, Rui-ling MA1, 2, Xiao-jie CHEN1, Jiao TIAN1, Yu-shun KOU1, Lin-na ZHANG1, Jia-wei LI1, Lin YI1, 2, Sheng-hui HUANG4, Xue-feng LIU1
Chinese Pharmacological Bulletin | 2026, 42(5) : 831 - 837
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Chinese Pharmacological Bulletin | 2026, 42(5): 831-837
Research advances in pathogenesis of hypertension with comorbid depression
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Yi-yuan WANG1, 2, Lu-fan SHEN1, Nan WANG3, Rui-ling MA1, 2, Xiao-jie CHEN1, Jiao TIAN1, Yu-shun KOU1, Lin-na ZHANG1, Jia-wei LI1, Lin YI1, 2, Sheng-hui HUANG4, Xue-feng LIU1
Affiliations
  • 1School of Integrated Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730030, China
  • 2Gansu Provincial Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Chronic Diseases, Lanzhou 730030, China
  • 3Dept of General Medicine, The First Hospital of Lanzhou University, Lanzhou 730030, China
  • 4Dept of Mental Diseases, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
Published: 2026-05-20 doi: 10.12360/CPB202508066
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Patients with hypertension often experience comorbid depression, and this co-occurrence significantly increases cardiovascular and cerebrovascular risk. A complex bidirectional relationship exists between hypertension and depression, where depression can exacerbate the progression of hypertension, and the course of hypertension can also induce mood disorders. The pathogenesis of their comorbidity involves multisystem interactions, including genetic susceptibility, overactivation of the renin-angiotensin system(RAS), dysregulation of the hypothalamic-pituitary-adrenal(HPA)axis, autonomic nervous system dysfunction, immune-inflammatory responses, and intestinal flora/metabolic abnormalities. Based on these mechanisms, characteristic biomarkers such as inflammatory factors, epigenetic regulation, vascular function, and neuroplasticity provide a basis for early disease identification. This paper systematically elaborates on the mechanisms and potential biomarkers of hypertension-depression comorbidity, aiming to offer new insights for its precise intervention.

hypertension  /  depression  /  comorbidity  /  pathogenesis  /  biomarkers  /  renin-angiotensin system
Yi-yuan WANG, Lu-fan SHEN, Nan WANG, Rui-ling MA, Xiao-jie CHEN, Jiao TIAN, Yu-shun KOU, Lin-na ZHANG, Jia-wei LI, Lin YI, Sheng-hui HUANG, Xue-feng LIU. Research advances in pathogenesis of hypertension with comorbid depression[J]. Chinese Pharmacological Bulletin, 2026 , 42 (5) : 831 -837 . DOI: 10.12360/CPB202508066
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doi: 10.12360/CPB202508066
  • Receive Date：2025-11-14
  • Online Date：2026-07-16
  • Published：2026-05-20
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  • Received：2025-11-14
  • Revised：2026-02-12
Affiliations
    1School of Integrated Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730030, China
    2Gansu Provincial Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Chronic Diseases, Lanzhou 730030, China
    3Dept of General Medicine, The First Hospital of Lanzhou University, Lanzhou 730030, China
    4Dept of Mental Diseases, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
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