To evaluate the effects of butorphanol combined with quadratus lumborum block （QLB） on postoperative analgesia and early rehabilitation quality in patients with colorectal cancer.

Sixty patients undergoing elective laparoscopic radical resection of colorectal cancer under general anesthesia were randomly divided into two groups, with 30 cases in each group. The induction and maintenance of anesthesia were the same in the two groups.Patients in group B received patient-controlled intravenous analgesia （PCIA） with butorphanol 0.2 mg·kg^-1 diluted to 200 mL with sodium chloride injection. Patients in group BQ received ultrasound-guided bilateral anterior QLB and 0.25% ropivacaine 20 mL was injected bilaterally on the basis of that in the group B. Visual analogue scale （VAS） and Bruggrmann comfort scale （BCS） were used to evaluate the analgesic effect of the two groups after operation. The serum levels of interleukin （IL）-6, C-reactive protein （CRP） and tumor necrosis factor （TNF） -α were detected before operation and 24 h after operation. The postoperative recovery and hospitalization satisfaction score of the patients were evaluated,the consumption of butorphanol and the requirement for rescue analgesia within 48 h after operation were recorded, and the occurrence of postoperative nausea and vomiting was observed.

The VAS scores of the group BQ were lower than those of the group B at 2, 6, 12 and 24 h after operation （P<0.05）, and the BCS scores of the group BQ were higher than those of the group B （P<0.05）. The levels of IL-6, TNF-α and CRP at 24 h after operation in both groups were higher than those before operation （P<0.05）, but those in the group BQ were lower than those in the group B （P<0.05）. The postoperative anal exhaust time, liquid food intake time, ambulation time and hospitalization time in the group BQ were shorter than those in the group B （P<0.05）, and the hospitalization satisfaction in the group BQ was higher than that in the group B （P<0.05）. The consumption of butorphanol within 48 h after operation in the group BQ was less than that in the group B （P<0.05）, and the requirement for rescue analgesia in the group BQ was lower than that in the group B （P<0.05）.No serious adverse reactions occurred in the two groups, but the incidence of nausea and vomiting in the group BQ was significantly lower than that in the group B （P<0.05）.

Butorphanol combined with QLB for postoperative analgesia in patients undergoing laparoscopic radical resection of colorectal cancer can effectively enhance the postoperative analgesic effect, reduce the inflammatory response of the body, and promote the early recovery of patients.