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To explore the median effective dose (ED50) of ciprofol combined with remifentanil for sedation in painless gastroscopy of school-aged children.
School-aged children scheduled for painless gastroscopy were selected, regardless of gender, aged 6-12 years old. Following the intravenous injection of remifentanil 0.5 μg·kg-1, the pediatric patient was administered with ciprofol (starting with an initial dose of 0.5 mg·kg-1, the dose for the next child was determined using the Dixon sequential method, based on the sedation situation. A decrease of 0.05 mg·kg-1 was applied for successful sedation, while an increase of 0.05 mg·kg-1 was applied for failed sedation). The ED50, 95% effective dose (ED95) and corresponding 95% confidence interval (CI) of ciprofol were calculated by Probit method. The mean arterial pressure (MAP), heart rate (HR), and respiratory rate (RR) of the pediatric patients before sedation (T0), after remifentanil administration (T1), and after ciprofol administration (T2), as well as the occurrence of adverse reactions were recorded.
The ED50 of ciprofol when combined with 0.5 μg·kg-1 remifentanil in anesthesia induction for school-aged children in painless gastroscopy was 0.302 mg·kg-1 (95% CI: 0.184 to 0.356 mg·kg-1)，and the ED95 was 0.461 mg·kg-1 (95% CI: 0.390 to 1.004 mg·kg-1). Compared with those at T0, the MAP, HR, and RR of the children decreased significantly at T1 and T2 (P<0.05). Compared with those at T1, only MAP decreased significantly at T2 (P<0.05).During the examination, there were 6 cases of hypotension, 5 cases of bradycardia, and 5 cases of respiratory depression (including 3 cases of transient apnea), with no injection pain or chest wall rigidity.
The ED50 of ciprofol combined with 0.5 μg·kg-1 remifentanil for sedation in painless gastroscopy of school-aged children was 0.302 mg·kg-1 (95% CI: 0.184 to 0.356 mg·kg-1)，and the ED95 was 0.461 mg·kg-1 (95% CI: 0.390 to 1.004 mg·kg-1).
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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