AIM To analyze the effects of different doses of ciprofol on general anesthesia induction in elderly patients, and the influence on hemodynamics during general anesthesia induction. METHODS One hundred and twenty elderly patients undergoing elective surgery were randomly included in ciprofol 0.2 mg·kg^-1 group (C_0.2 group), ciprofol 0.3 mg·kg^-1 group (C_0.3 group) and ciprofol 0.4 mg·kg^-1 group (C_0.4 group), with 40 cases in each group. The corresponding dose of ciprofol was injected intravenously according to the group, and the injection time was 30 s. And all patients induced by rocuronium 0.6 mg·kg^-1 and sufentanil 0.5 μg·kg^-1 were injected intravenously, followed by ciprofol 0.8-2.4 mg·kg^-1·h^-1, remifentanil 8-15 μg·kg^-1·h^-1 was injected intravenously and 1% sevoflurane was inhaled for anesthesia maintenance. The bispectral index (BIS) was maintained 40~60 during the operation. The mean arterial pressure (MAP), heart rate (HR) and BIS of the patients were monitored, the success rate of anesthesia induction, the number of cases of remedial sedation and the time of loss of consciousness were recorded, and the occurrence of adverse reactions were observed. RESULTS The MAP, HR and BIS of the three groups immediately after anesthesia induction (T₁), 10 s after tracheal intubation (T₂) and 3 min after tracheal intubation (T₃) were significantly lower than those of the same group at the time of entering the operating room (P<0.05), and the MAP and HR of T₁-T₃ in the C_0.4 group were significantly lower than those in the C_0.2 group and C_0.3 groups (P<0.05). There were no significant differences in MAP and HR of T₁-T₃ between the C_0.3 group and C_0.2 group (P>0.05). There were no significant differences in the success rate of anesthesia induction among the three groups (P>0.05). The rate of remedial sedation in the C_0.2 group was significantly higher than that in the C_0.3 group and C_0.4 group (P<0.05), and the time of consciousness loss was significantly longer than that in the C_0.3 group and C_0.4 group (P<0.05). There was no significant difference in rate of remedial sedation and consciousness loss time between the C_0.3 group and C_0.4 group (P>0.05). The incidence of hypotension and bradycardia in the C_0.4 group was significantly higher than that in the C_0.2 group and C_0.3 group (P<0.05), but there was no significant difference in the incidence of hypotension and bradycardia between the C_0.3 group and C_0.2 group (P>0.05). CONCLUSION Ciprofol 0.3 mg·kg^-1 has good safety and efficacy for general anesthesia induction in elderly patients.