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The use of polyethylene glycol (PEG) modified drugs or nano-carriers is a widely accepted method that can effectively improve therapeutic effects of drugs in vivo. However, PEGylated drugs are usually immunogenic in vivo and can trigger the secretion of anti-PEG immunoglobulin IgG and IgM, leading to a significant increase in blood clearance efficiency of drugs and the occurrence of hypersensitivity reactions. The physicochemical properties of PEG molecules,drugs, or drug carriers will affect the secretion of anti-PEG antibodies, and the PEG modification density and administration frequency will also affect the immunogenicity of PEGylated drugs. Optimizing the causes and influencing factors is an effective method to improve the immunogenicity of PEGylated drugs in vivo. PEG alternative biomaterial is a new direction of drug research and development.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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