PDF
Full
Outline
The efficacy of interleukin (IL)-2 in tumor immunotherapy is remarkable, but its adverse reactions greatly limit its further clinical application. In recent years, researchers have tried to improve or regulate the receptor selectivity of IL-2, that is, selectively bias the activation of IL-2Rβγ and reduce or even completely do not bind to IL-2Rα, so as to preferentially activate CD8+ T cells with tumor killing function and maximize the immune activation of IL-2. The main development strategies of receptor biased IL-2 include polyethylene glycol chemical modification and site-specific mutation technology. Currently, the drugs under research include NKTR-214, THOR-707, SHR-1916, TransConIL-2β/γ, 8MW2311,RG7461, FSD13, IBI363, etc. But none of them have been successfully developed yet. Further in-depth research on their mechanisms of action is required, or various drug development strategies need to be used in combination.
PDF
130
59
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
