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Progress in research and application of local anti-glaucoma drugs
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Wan MUa, Ying-zhuo DINGa, Yu-fei XIa, Shen-yu BENb, Bin CHENb, Ling GEb
Chinese Journal of New Drugs and Clinical Remedies | 2024, 43(8) : 574 - 581
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Chinese Journal of New Drugs and Clinical Remedies | 2024, 43(8): 574-581
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Progress in research and application of local anti-glaucoma drugs
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Wan MUa, Ying-zhuo DINGa, Yu-fei XIa, Shen-yu BENb, Bin CHENb, Ling GEb
Affiliations
  • a.Department of Pharmacy, Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University, SHANGHAI 200331, China
  • b.Department of Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University, SHANGHAI 200331, China
Published: 2024-08-25 doi: 10.14109/j.cnki.xyylc.2024.08.03
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Glaucoma, a leading cause of irreversible blindness worldwide, primarily involves pathological elevation of intraocular pressure (IOP), which is its main risk factor, so the clinical goal in treating glaucoma is to reduce IOP to individual target levels. Currently, the classical local anti-glaucoma drugs include five categories: prostaglandin analogues(PGAs), β-adrenergic receptor blockers, α2- adrenergic receptor agonists, carbonic anhydrase inhibitors, and cholinergic receptor agonists. These drugs mainly work by reducing aqueous humor production, increasing aqueous outflow through the trabecular pathway and the uveal scleral pathway, and contracting the pupil sphincter to open the chamber angle. Among these, PGAs have become the preferred choice for controlling IOP in primary open-angle glaucoma patients due to their efficacy and safety. In recent years, the introduction of novel glaucoma medications, including Rho kinase inhibitors and nitric oxide-donating anti-glaucoma drugs, along with the development of related drug-releasing formulations (intraocular and extraocular drug delivery systems), offers new options for glaucoma treatment.

glaucoma  /  intraocular pressure  /  prostaglandin analogues  /  Rho kinase inhibitors  /  nitric oxide donors  /  sustained release gel
Wan MU, Ying-zhuo DING, Yu-fei XI, Shen-yu BEN, Bin CHEN, Ling GE. Progress in research and application of local anti-glaucoma drugs[J]. Chinese Journal of New Drugs and Clinical Remedies, 2024 , 43 (8) : 574 -581 . DOI: 10.14109/j.cnki.xyylc.2024.08.03
Year 2024 volume 43 Issue 8
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doi: 10.14109/j.cnki.xyylc.2024.08.03
  • Receive Date:2023-05-29
  • Online Date:2026-03-13
  • Published:2024-08-25
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  • Received:2023-05-29
  • Accepted:2024-03-25
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Affiliations
    a.Department of Pharmacy, Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University, SHANGHAI 200331, China
    b.Department of Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University, SHANGHAI 200331, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
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Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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