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To analyze the general patterns and characteristics of osimertinib related interstitial lung disease（ILD）.
The case reports of osimertinib related ILD from CNKI, VIP, Wanfang and PubMed database between November 2015 to June 2023 were searched and analyzed.
A total of 25 case reports were enrolled,involving 28 cases with ILD, 14 male and 14 female cases, aged 32 to 86 years old. PD-1 inhibitors were used sequentially in 4 patients before administering osimertinib, 21 patients developed ILD in 3 months, 25 patients experienced symptom relief after discontinuation reduction medication, and 3 patients died.
ILD should be closely guarded in 3 months of the application of osimertinib, especially these patients who received the sequence treatment of PD-1 inhibitors.The key to improving the prognosis is to stop using osimertinib immediately after ILD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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