To explore the effects of esmolol on hemodynamics and inflammatory reaction during endoscopic sinus surgery in patients with sinusitis.

Eighty patients with sinusitis undergoing endoscopic sinus surgery were randomly divided into control group and trial group, with 40 patients in each group. The control group received routine anesthesia induction and maintenance, while the trial group received an additional 0.5 mg·kg^-1 of esmolol injection during anesthesia induction and 30 μg·kg^-1·min^-1 of esmolol pump injection during anesthesia maintenance. The blood pressure and heart rate of patients were observed, the levels of interleukin（IL）-6, tumor necrosis factor（TNF）-α and C-reactive protein（CRP）in the blood were detected, and the recovery time, intraoperative blood loss, propofol dosage, remifentanil dosage and postoperative nausea and vomiting rate were compared between the two groups.

The systolic blood pressure, diastolic blood pressure, and heart rate of the trial group were lower than those in the control group at entering the operating room, the time of tracheal intubation, the beginning of surgery, 1 h after the beginning of surgery（T₃）, the end of surgery（T₄）, and the time of tracheal intubation was removed（P<0.01）. The levels of IL-6, TNF-α and CRP at T₃ and T₄ in the trial group were also lower than those in the control group（P<0.01）. The recovery time of the trial group was significantly shorter than that of the control group（P<0.01）, and the amount of intraoperative blood loss, propofol and remifentanil was significantly lower than that of the control group（P<0.01）. The incidence of postoperative nausea and vomiting in the trial group was lower than that in the control group（P<0.05）.

Esmolol is beneficial to maintain the stable hemodynamics of patients with sinusitis during endoscopic sinus surgery, can reduce inflammatory reaction, reduce intraoperative blood loss and the dosage of general anesthetics, and is relatively safe.