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Acne vulgaris is one of the most common skin diseases in dermatology. Retinoids are commonly used in the treatment of this disease. Trifarotene is derived from CD437, a triaryl skeleton lead compound with retinoic acid receptor subtype selectivity, after the optimization of receptor structure. It is called the fourth generation retinoic acid anti-acne drug because of its high selectivity for retinoic acid γ receptor（RAR-γ）. In October 2019, trifarotene was approved by the U.S.Food and Drug Administration for the treatment of acne vulgaris in patients aged 9 and above. Clinical trials have shown that trifarotene is safe, effective and well tolerated in the treatment of acne vulgaris, which has a good clinical application prospect.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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