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Research progress of a new lipid-regulating drug pemafibrate in therapeutic application
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Ya-zhi WANG, Hui CHEN
Chinese Journal of New Drugs and Clinical Remedies | 2024, 43(3) : 182 - 187
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Chinese Journal of New Drugs and Clinical Remedies | 2024, 43(3): 182-187
New Drug Introduction
Research progress of a new lipid-regulating drug pemafibrate in therapeutic application
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Ya-zhi WANG, Hui CHEN
Affiliations
  • Department of Endocrinology and Metabolism, the Second Hospital of Lanzhou University, Lanzhou GANSU 730030, China
Published: 2024-03-25 doi: 10.14109/j.cnki.xyylc.2024.03.04
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Pemafibrate, a new type of fibrates developed in Japan, was approved for marketing in Japan in June 2018. Compared with traditional fibrates, pemafibrate can combine peroxisome proliferator activated receptor α (PPARα) purposefully, and then regulate lipid metabolism effectively. Studies have shown that pemafibrate can not only improve blood lipid levels, but also regulate blood glucose, maintain liver metabolism, inhibit inflammation and thrombosis, and may have certain application value in people with diabetes, liver diseases, and cardiovascular diseases. The common adverse reactions are allergy, nasopharyngitis, creatine kinase elevation, blood uric acid elevation and so on.

pemafibrate  /  lipid regulating agents  /  peroxisome proliferator activated receptor alpha  /  hyperlipidemias
Ya-zhi WANG, Hui CHEN. Research progress of a new lipid-regulating drug pemafibrate in therapeutic application[J]. Chinese Journal of New Drugs and Clinical Remedies, 2024 , 43 (3) : 182 -187 . DOI: 10.14109/j.cnki.xyylc.2024.03.04
Year 2024 volume 43 Issue 3
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doi: 10.14109/j.cnki.xyylc.2024.03.04
  • Receive Date:2022-04-08
  • Online Date:2026-03-13
  • Published:2024-03-25
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  • Received:2022-04-08
  • Accepted:2023-03-03
Affiliations
    Department of Endocrinology and Metabolism, the Second Hospital of Lanzhou University, Lanzhou GANSU 730030, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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