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To evaluate the influences of vitamin D2 injection on serum 25-hydroxyvitmin D （25（OH）D） and immune function in men with vitamin D deficiency aged 80 and over.
A total of 48 men with vitamin D deficiency aged 80 and over were given intramuscular vitamin D2 600 000 IU every month until the serum 25（OH）D reached and over 30 µg·L-1. The levels of serum 25（OH）D2, 25（OH）D3, T lymphocyte cells （including CD3+, CD4+, CD8+）, B lymphocyte cells （CD19+）, and blood calcium and phosphorus were detected before and after treatment. And adverse reactions were observed.
A total of 40 patients completed the study. It took （6.2±1.4） months for 25（OH）D to reach targeted serum concentration. Compared with those before treatment, the serum levels of 25（OH）D2 after the treatment increased by （27.42±5.47） µg·L-1, 25（OH）D3 decreased by （5.25±3.38） µg·L-1, and the total 25（OH）D increased by （22.45±6.15） µg·L-1 （all P<0.01）. And the serum levels of CD4+ T cells increased by （3.71±6.26）%, CD4+/CD8+ increased 0.31±0.93, and CD19+ B cell increased by （1.50±3.31）% （all P<0.05）. There were no significant differences in serum CD3+ T cells, alanine aminotransferase, blood glucose, creatinine, calcium, and phosphorus before and after the treatment （P>0.05）. No severe adverse drug reactions occurred during the treatment.
Vitamin D2 injection is helpful for increasing serum 25（OH）D2 levels and regulating immune function in men with vitamin D deficiency aged 80 and over.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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