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To study the effect of a single dose of dexamethasone on reversal of rocuronium deep neuromuscular blockade （NMB） by sugammadex.
A total of 80 patients undergoing laparoscopic colon surgeries under general anesthesia were selected, with ASA Ⅰ- Ⅱ, and not taking steroid drug medication. The patients were randomly divided into 2 groups with 40 cases in each group. Before anesthesia induction, the trial group was given dexamethasone 0.15 mg·kg-1, and the control group was given the same amount of chloride sodium injection. The induction and maintenance programs of anesthesia were the same in both groups. Rocuronium was administered intravenously for 5 - 10 µg·kg-1·min-1 to maintain deep muscle relaxation, and the post-tetanic count （PTC） was maintained at 0 - 2. After operation, all patients were immediately intravenously injected with sugammadex at a dose of 2 mg·kg-1 when PTC was 1 - 2. The time for train of four-ratios （TOFR） to reach 0.9, extubation time and occurrence of adverse reactions were recorded.
The time of TOFR recovery to 0.9, extubation time and post-anesthesia care unit （PACU） residence time were （6.0±0.7）,（7.5±0.5） and （36.8±5.8） min in the control group, and （6.0±0.6）, （7.7±0.5） and （39.7±6.2） min in the trial group, respectively，with no significant differences between the two groups （P>0.05）. There were no differences in mean arterial pressure and heart rate between the two groups before surgery, at the time of sugammadex administration, and 5 and 10 min after administration （P>0.05）. No adverse reactions occurred in the both groups.
Dexamethasone 0.15 mg·kg-1 has no significant effect on the reversal of deep NMB by sugammadex.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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