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To evaluate the safety and efficacy of dronedarone in the blanking period in patients underwent atrial fibrillation catheter ablation in the real-world.
A total of 150 patients with atrial fibrillation who underwent catheter ablation at co-operative centers between May 1st, 2021 and December 31st, 2021 were included. During the blanking period, the patients were given oral dronedarone（400 mg, morning and evening）for 3 months. At 3 months ± 14 days after surgery, the patients were followed up, and 24-hour Holter, transthoracic echocardiography, liver function and renal function were reviewed. The adverse events occurred during the follow-up were recorded.
Compared with before surgery,there were no significant differences in heart rate, PR interval, and left ventricular ejection fraction were observed at 3 months after surgery, while QTc interval increased（（434.0±29.2）ms vs.（443.5±31.8）ms, P=0.017））. Left atrial diameter（（40.6±6.5）mm vs.（38.4±6.0）mm, P=0.007））and lower left ventricular end-diastolic diameter（（47.9±4.3）mm vs.（46.4±5.1）mm, P=0.012））decreased. Six patients discontinued in the blanking period（included high atrioventricular block in 1 patient, significant bradycardia in 2 patients, significant prolongation of the QTc interval in 1 patient, and digestive system symptoms in 2 patients）. There were no composite endpoints of cardiovascular death, heart failure or rehospitalization associated with antiarrhythmic drugs. At follow-up of 3 months, the rate of sinus rhythm maintenance was 85.3%（128/150）.
Dronedarone is safe and effective in the blanking period for patients underwent atrial fibrillation catheter ablation. Moreover, it’s good in adherence.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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